Vitamin E modifies high-fat diet-induced reduction of seizure threshold in rats: Role of oxidative stress

2019 ◽  
Vol 206 ◽  
pp. 200-205 ◽  
Author(s):  
Karem H. Alzoubi ◽  
Zuhair A. Hasan ◽  
Omar F. Khabour ◽  
Fadia A. Mayyas ◽  
Omar N. Al Yacoub ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
High Fat Diet ◽  
Seizure Threshold ◽  
High Fat

The effect of high-fat diet on seizure threshold in rats: Role of oxidative stress

2018 ◽  
Vol 196 ◽  
pp. 1-7 ◽  
Author(s):  
Karem H. Alzoubi ◽  
Zuhair A. Hasan ◽  
Omar F. Khabour ◽  
Fadia A. Mayyas ◽  
Omar N. Al Yacoub ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
High Fat Diet ◽  
Seizure Threshold ◽  
High Fat

Melatonin prevents memory impairment induced by high-fat diet: Role of oxidative stress

2018 ◽  
Vol 336 ◽  
pp. 93-98 ◽  
Author(s):  
Karem H. Alzoubi ◽  
Fadia A. Mayyas ◽  
Rania Mahafzah ◽  
Omar F. Khabour
Keyword(s):  
Oxidative Stress ◽  
High Fat Diet ◽  
Memory Impairment ◽  
High Fat

scholarly journals Açaí (Euterpe oleracea Mart.) seed extract protects against hepatic steatosis and fibrosis in high-fat diet-fed mice: Role of local renin-angiotensin system, oxidative stress and inflammation

2020 ◽  
Vol 65 ◽  
pp. 103726 ◽  
Author(s):  
Matheus Henrique Romão ◽  
Graziele Freitas de Bem ◽  
Izabelle Barcellos Santos ◽  
Ricardo de Andrade Soares ◽  
Dayane Teixeira Ognibene ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hepatic Steatosis ◽  
High Fat Diet ◽  
Renin Angiotensin System ◽  
Seed Extract ◽  
Euterpe Oleracea ◽  
High Fat ◽  
Angiotensin System ◽  
Euterpe Oleracea Mart

Every-other day fasting prevents memory impairment induced by high fat-diet: Role of oxidative stress

2021 ◽  
Vol 229 ◽  
pp. 113263
Author(s):  
Karem H. Alzoubi ◽  
Omar F. Khabour ◽  
Rafat M Al-Awad ◽  
Zainah O. Aburashed
Keyword(s):  
Oxidative Stress ◽  
High Fat Diet ◽  
Memory Impairment ◽  
High Fat

scholarly journals Role of Supplementary Selenium on the Induction of Insulin Resistance and Oxidative Stress in NSY Mice Fed a High Fat Diet

2018 ◽  
Vol 41 (1) ◽  
pp. 92-98 ◽  
Author(s):  
Koichi Murano ◽  
Hirofumi Ogino ◽  
Tomofumi Okuno ◽  
Tomohiro Arakawa ◽  
Hitoshi Ueno
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
High Fat Diet ◽  
High Fat ◽  
And Oxidative Stress

scholarly journals The high-fat diet induces myocardial fibrosis in the metabolically healthy obese minipigs—The role of ER stress and oxidative stress

2017 ◽  
Vol 36 (3) ◽  
pp. 760-767 ◽  
Author(s):  
Sin-Jin Li ◽  
Chia-Hsin Liu ◽  
Hsien-Pin Chu ◽  
Harry J. Mersmann ◽  
Shih-Torng Ding ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Er Stress ◽  
Myocardial Fibrosis ◽  
High Fat Diet ◽  
High Fat ◽  
Metabolically Healthy Obese ◽  
Healthy Obese ◽  
Metabolically Healthy ◽  
And Oxidative Stress

Hepatic accumulation of S-adenosylmethionine in hamsters with non-alcoholic fatty liver disease associated with metabolic syndrome under selenium and vitamin E deficiency

2019 ◽  
Vol 133 (3) ◽  
pp. 409-423 ◽  
Author(s):  
Josep Maria del Bas ◽  
Benjamín Rodríguez ◽  
Francesc Puiggròs ◽  
Silvia Mariné ◽  
Miguel Angel Rodríguez ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Metabolic Syndrome ◽  
Vitamin E ◽  
High Fat Diet ◽  
Fatty Liver Disease ◽  
Cell Cycle Control ◽  
High Fat ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

AbstractProgression of non-alcoholic fatty liver disease (NAFLD) in the context of metabolic syndrome (MetS) is only partially explored due to the lack of preclinical models. In order to study the alterations in hepatic metabolism that accompany this condition, we developed a model of MetS accompanied by the onset of steatohepatitis (NASH) by challenging golden hamsters with a high-fat diet low in vitamin E and selenium (HFD), since combined deficiency results in hepatic necroinflammation in rodents. Metabolomics and transcriptomics integrated analyses of livers revealed an unexpected accumulation of hepatic S-Adenosylmethionine (SAM) when compared with healthy livers likely due to diminished methylation reactions and repression of GNMT. SAM plays a key role in the maintenance of cellular homeostasis and cell cycle control. In agreement, analysis of over-represented transcription factors revealed a central role of c-myc and c-Jun pathways accompanied by negative correlations between SAM concentration, MYC expression and AMPK phosphorylation. These findings point to a drift of cell cycle control toward senescence in livers of HFD animals, which could explain the onset of NASH in this model. In contrast, hamsters with NAFLD induced by a conventional high-fat diet did not show SAM accumulation, suggesting a key role of selenium and vitamin E in SAM homeostasis. In conclusion, our results suggest that progression of NAFLD in the context of MetS can take place even in a situation of hepatic SAM excess and that selenium and vitamin E status might be considered in current therapies against NASH based on SAM supplementation.

scholarly journals Effect of Acute Ingestion of Green Tea Extract and Lemon Juice on Oxidative Stress and Lipid Profile in Pigs Fed a High-Fat Diet

Antioxidants ◽  
2019 ◽  
Vol 8 (6) ◽  
pp. 195 ◽  
Author(s):  
Xi Fang ◽  
Michael Azain ◽  
Kristi Crowe-White ◽  
Jennifer Mumaw ◽  
Janet A. Grimes ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Single Dose ◽  
Lipid Profile ◽  
Green Tea ◽  
High Fat Diet ◽  
Lemon Juice ◽  
Green Tea Extract ◽  
High Fat ◽  
Tea Extract

Green tea and its catechins have been shown to ameliorate high fat diet-induced oxidative stress and hyperlipidemia. However, low bioavailability of catechins limits their therapeutic potential. Lemon juice (LJ) has been suggested to enhance the bioavailability of catechins in vitro. This study investigated the antioxidative and hypolipidemic efficacy of a single dose of green tea extract (GTE) or GTE plus LJ (GTE + LJ) in high-fat diet fed pigs. Sixteen pigs ingested a single dose of GTE (190 mg/kg/day) or GTE + LJ (0.75 mL/kg/day) mixed with low-fat (LF; 5% fat) or high-fat (HF; 22% fat) diets and blood samples were collected for 24 h. Plasma catechin level peaked at two hours, and gradually returned to baseline after six hours following the intake. The addition of LJ significantly increased plasma catechin level. The diet containing GTE did not lower plasma cholesterol and triacylglycerol (TG) concentrations, superoxide dismutase (SOD) and catalase activity, or malondialdehyde concentration in 24 h in HF-fed pigs. Addition of a single dose of LJ, however, significantly decreased plasma TG level in LF groups but did not cause further changes on any other markers compared to the GTE alone. Our findings indicate limited effect of a single meal containing GTE on plasma antioxidant enzymes, lipid profile, and lipid peroxidation in pigs and no significant synergistic/additive action of adding LJ to GTE within 24 h in pigs. A study with a longer treatment period is warranted to further understand the potential role of GTE in reducing HF diet-induced oxidative stress and the possible synergistic role of LJ.

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