scholarly journals The high-fat diet induces myocardial fibrosis in the metabolically healthy obese minipigs—The role of ER stress and oxidative stress

2017 ◽  
Vol 36 (3) ◽  
pp. 760-767 ◽  
Author(s):  
Sin-Jin Li ◽  
Chia-Hsin Liu ◽  
Hsien-Pin Chu ◽  
Harry J. Mersmann ◽  
Shih-Torng Ding ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Er Stress ◽  
Myocardial Fibrosis ◽  
High Fat Diet ◽  
High Fat ◽  
Metabolically Healthy Obese ◽  
Healthy Obese ◽  
Metabolically Healthy ◽  
And Oxidative Stress

scholarly journals Role of Supplementary Selenium on the Induction of Insulin Resistance and Oxidative Stress in NSY Mice Fed a High Fat Diet

2018 ◽  
Vol 41 (1) ◽  
pp. 92-98 ◽  
Author(s):  
Koichi Murano ◽  
Hirofumi Ogino ◽  
Tomofumi Okuno ◽  
Tomohiro Arakawa ◽  
Hitoshi Ueno
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
High Fat Diet ◽  
High Fat ◽  
And Oxidative Stress

W1864 Increased ER Stress, NRF2 Expression and Oxidative Stress in Cyp2e1 Transgenic Mice Fed a High Fat Diet

2008 ◽  
Vol 134 (4) ◽  
pp. A-840-A-841
Author(s):  
Philip T. Chen ◽  
Elango Kathirvel ◽  
Kengathevy Morgan ◽  
Timothy R. Morgan
Keyword(s):  
Oxidative Stress ◽  
Transgenic Mice ◽  
Er Stress ◽  
High Fat Diet ◽  
High Fat ◽  
Nrf2 Expression ◽  
And Oxidative Stress

scholarly journals Panax Notoginseng Protects against Diabetes-Associated Endothelial Dysfunction: Comparison between Ethanolic Extract and Total Saponin

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Xutao Zhang ◽  
Chunxiu Zhou ◽  
Lingchao Miao ◽  
Yi Tan ◽  
Yan Zhou ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Er Stress ◽  
High Glucose ◽  
High Fat Diet ◽  
Ex Vivo ◽  
Ethanolic Extract ◽  
Panax Notoginseng ◽  
Protective Effects ◽  
High Fat ◽  
And Oxidative Stress

Previous studies revealed a cardioprotective potential of Panax notoginseng to relieve acute myocardial infarction and focal cerebral ischemia-reperfusion. However, whether P. notoginseng protects endothelial function in diabetes and the underlying mechanisms remain to be explored. P. notoginseng contains several chemical components including saponins, which are commonly believed as the major bioactive ingredients. The present study was aimed to examine and compare the vaso-protective effects of the ethanolic extract of P. notoginseng (PNE) and total saponin (PNS). Both aortas and carotid arteries were isolated from male C57BL/6J mice for ex vivo treatment with risk factors (high glucose or tunicamycin) with and without the presence of PNS and PNE. Diabetic model was established by feeding the mice with a high-fat diet (45% kcal% fat) for 12 weeks, while PNS and PNE were administrated by oral gavage at 20 mg/kg/day for another 4 weeks. Ex vivo exposure to high glucose impaired acetylcholine-induced endothelium-dependent relaxations in mouse aortas, decreased phosphorylation of AMPK and eNOS, and induced endoplasmic reticulum (ER) stress and oxidative stress. These effects were reversed by cotreatment of PNS and PNE with PNS being more potent. Furthermore, the vaso-protective effects were abolished by Compound C (AMPK inhibitor). Chronic treatment with PNS and PNE improved endothelium-dependent relaxations and alleviated ER stress and oxidative stress in aortas from high-fat diet-induced obese mice. PNE was more effective to improve glucose sensitivity and normalize blood pressure in diabetic mice. The present results showed that PNS and PNE reduced ER stress and oxidative stress and, subsequently, improved endothelial function in diabetes through AMPK activation. This study provides new inspiration on the therapeutic potential of P. notoginseng extract against vascular diseases associated with metabolic disorders.

Role of Sirt3 in sex-related response to high fat diet-induced metabolic and oxidative stress in mice

2021 ◽  
Vol 177 ◽  
pp. S115
Author(s):  
Iva Skrinjar ◽  
Iva I. Podgorski ◽  
Marija Pinteric ◽  
Marijana Popovic Hadzija ◽  
Ivana Tartaro Bujak ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
High Fat Diet ◽  
High Fat ◽  
Related Response ◽  
And Oxidative Stress

Melatonin prevents memory impairment induced by high-fat diet: Role of oxidative stress

2018 ◽  
Vol 336 ◽  
pp. 93-98 ◽  
Author(s):  
Karem H. Alzoubi ◽  
Fadia A. Mayyas ◽  
Rania Mahafzah ◽  
Omar F. Khabour
Keyword(s):  
Oxidative Stress ◽  
High Fat Diet ◽  
Memory Impairment ◽  
High Fat

Improvement for High Fat Diet-Induced Hepatic Injuries and Oxidative Stress by Flavonoid-Enriched Extract from Nelumbo nucifera Leaf

2009 ◽  
Vol 57 (13) ◽  
pp. 5925-5932 ◽  
Author(s):  
Ming-Cheng Lin ◽  
Shao-Hsuan Kao ◽  
Pei-Jun Chung ◽  
Kuei-Chuan Chan ◽  
Mon-Yuan Yang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
High Fat Diet ◽  
Nelumbo Nucifera ◽  
High Fat ◽  
Hepatic Injuries ◽  
And Oxidative Stress

scholarly journals Effects of a Mixed Limosilactobacillus fermentum Formulation with Claimed Probiotic Properties on Cardiometabolic Variables, Biomarkers of Inflammation and Oxidative Stress in Male Rats Fed a High-Fat Diet

Foods ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 2202
Author(s):  
Micaelle Oliveira de Luna Freire ◽  
Luciana Caroline Paulino do Nascimento ◽  
Kataryne Árabe Rimá de Oliveira ◽  
Alisson Macário de Oliveira ◽  
Thiago Henrique Napoleão ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
High Fat Diet ◽  
Control Diet ◽  
Male Rats ◽  
Control Group ◽  
Low Grade ◽  
Probiotic Properties ◽  
High Fat ◽  
Low Grade Inflammation ◽  
And Oxidative Stress

High-fat diet (HFD) consumption has been linked to dyslipidemia, low-grade inflammation and oxidative stress. This study investigated the effects of a mixed formulation with Limosilactobacillusfermentum 139, L. fermentum 263 and L. fermentum 296 on cardiometabolic parameters, fecal short-chain fatty acid (SCFA) contents and biomarkers of inflammation and oxidative stress in colon and heart tissues of male rats fed an HFD. Male Wistar rats were grouped into control diet (CTL, n = 6), HFD (n = 6) and HFD with L. fermentum formulation (HFD-Lf, n = 6) groups. The L.fermentum formulation (1 × 109 CFU/mL of each strain) was administered twice a day for 4 weeks. After a 4-week follow-up, biochemical parameters, fecal SCFA, cytokines and oxidative stress variables were evaluated. HFD consumption caused hyperlipidemia, hyperglycemia, low-grade inflammation, reduced fecal acetate and propionate contents and increased biomarkers of oxidative stress in colon and heart tissues when compared to the CTL group. Rats receiving the L. fermentum formulation had reduced hyperlipidemia and hyperglycemia, but similar SCFA contents in comparison with the HFD group (p < 0.05). Rats receiving the L. fermentum formulation had increased antioxidant capacity throughout the colon and heart tissues when compared with the control group. Administration of a mixed L. fermentum formulation prevented hyperlipidemia, inflammation and oxidative stress in colon and heart tissues induced by HFD consumption.

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