A comparison of different models with motor dysfunction after traumatic brain injury in adult rats

2014 ◽  
Vol 13 (04) ◽  
pp. 579-593 ◽  
Author(s):  
Meng Wang ◽  
Hongjian Pu ◽  
Yingchao Liu ◽  
Zengtao Wang ◽  
Bomin Wang ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Motor Dysfunction ◽  
Adult Rats

scholarly journals Neural correlates of motor dysfunction in children with traumatic brain injury: exploration of compensatory recruitment patterns

Brain ◽  
2009 ◽  
Vol 132 (3) ◽  
pp. 684-694 ◽  
Author(s):  
K. Caeyenberghs ◽  
N. Wenderoth ◽  
B. C. M. Smits-Engelsman ◽  
S. Sunaert ◽  
S. P. Swinnen
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Neural Correlates ◽  
Motor Dysfunction ◽  
Recruitment Patterns

Cell Proliferation in the Brains of Adult Rats Exposed to Traumatic Brain Injury

2013 ◽  
pp. 27-38
Author(s):  
Sandra A. Acosta ◽  
Naoki Tajiri ◽  
Paula C. Bickford ◽  
Cesar V. Borlongan
Keyword(s):  
Traumatic Brain Injury ◽  
Cell Proliferation ◽  
Brain Injury ◽  
Adult Rats

Spatial and temporal dynamics of HDACs class IIa following mild traumatic brain injury in adult rats

2022 ◽  
Author(s):  
Swatabdi R. Kamal ◽  
Shreya Potukutchi ◽  
David J. Gelovani ◽  
Robin E. Bonomi ◽  
Srinivasu Kallakuri ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Temporal Dynamics ◽  
Adult Rats ◽  
Spatial And Temporal Dynamics

Intracranial bone marrow transplantation after traumatic brain injury improving functional outcome in adult rats

2001 ◽  
Vol 94 (4) ◽  
pp. 589-595 ◽  
Author(s):  
Asim Mahmood ◽  
Dunyue Lu ◽  
Yi Li ◽  
Jae Li Chen ◽  
Michael Chopp
Keyword(s):  
Traumatic Brain Injury ◽  
Bone Marrow ◽  
Brain Injury ◽  
Motor Function ◽  
Glial Fibrillary Acid Protein ◽  
Protein Markers ◽  
Adult Rats ◽  
Content Type ◽  
The Impact ◽  
Fine Print

Object. The authors tested the hypothesis that intracranial bone marrow (BM) transplantation after traumatic brain injury (TBI) in rats provides therapeutic benefit. Methods. Sixty-six adult Wistar rats, weighing 275 to 350 g each, were used for the experiment. Bone marrow prelabeled with bromodeoxyuridine (BrdU) was harvested from tibias and femurs of healthy adult rats. Other animals were subjected to controlled cortical impact, and BM was injected adjacent to the contusion 24 hours after the impact. The animals were killed at 4, 7, 14, or 28 days after transplantation. Motor function was evaluated both before and after the injury by using the rotarod test. After the animals had been killed, brain sections were examined using hemotoxylin and eosin and immunohistochemical staining methods. Histological examination revealed that, after transplantation, BM cells survived, proliferated, and migrated toward the injury site. Some of the BrdU-labeled BM cells were reactive, with astrocytic (glial fibrillary acid protein) and neuronal (NeuN and microtubule-associated protein) markers. Transplanted BM expressed proteins phenotypical of intrinsic brain cells, that is, neurons and astrocytes. A statistically significant improvement in motor function in rats that underwent BM transplantation, compared with control rats, was detected at 14 and 28 days posttransplantation. Conclusions. On the basis of their findings, the authors assert that BM transplantation improves neurological outcome and that BM cells survive and express nerve cell proteins after TBI.

scholarly journals Increased Vulnerability of NFH-LacZ Transgenic Mouse to Traumatic Brain Injury-Induced Behavioral Deficits and Cortical Damage

1999 ◽  
Vol 19 (7) ◽  
pp. 762-770 ◽  
Author(s):  
Michio Nakamura ◽  
Kathryn E. Saatman ◽  
James E. Galvin ◽  
Uwe Scherbel ◽  
Ramesh Raghupathi ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Motor Dysfunction ◽  
Tissue Loss ◽  
Post Injury ◽  
Behavioral Deficits ◽  
Beam Balance ◽  
Brain Injured ◽  
Neuromotor Function ◽  
Histopathologic Analysis

The authors evaluated the neurobehavioral and neuropathologic sequelae after traumatic brain injury (TBI) in transgenic (TG) mice expressing truncated high molecular weight neurofilament (NF) protein fused to beta-galactosidase (NFH-LacZ), which develop Lewy body-like NF-rich inclusions throughout the CNS. TG mice and their wild-type (WT) littermates were subjected to controlled cortical impact brain injury (TG, n=19; WT, n=17) or served as uninjured controls (TG, n =11; WT, n =11). During a 3-week period, mice were evaluated with an array of neuromotor function tests including neuroscore, beam balance, and both fast and slow acceleration rotarod. Brain-injured WT and TG mice showed significant motor dysfunction until 15 days and 21 days post-injury, respectively ( P < .025). Compared with brain-injured WT mice, brain-injured TG mice had significantly greater motor dysfunction as assessed by neuroscore ( P < .01) up to and including 15 days post-injury. Similarly, brain-injured TG mice performed significantly worse than brain-injured WT mice on slow acceleration rotarod at 2, 8, and 15 days post-injury ( P < .05), and beam balance over 2 weeks post-injury ( P < .01). Histopathologic analysis showed significantly greater tissue loss in the injured hemisphere in TG mice at 4 weeks post-injury ( P < .01). Together these data show that NFH-LacZ TG mice are more behaviorally and histologically vulnerable to TBI than WT mice, suggesting that the presence of NF-rich inclusions may exacerbate neuromotor dysfunction and cell death after TBI.

scholarly journals Remote Traumatic Brain Injury Is Associated with Motor Dysfunction in Older Military Veterans

2017 ◽  
Vol 72 (9) ◽  
pp. 1233-1238 ◽  
Author(s):  
Raquel C Gardner ◽  
Carrie B Peltz ◽  
Kimbra Kenney ◽  
Kenneth E Covinsky ◽  
Ramon Diaz-Arrastia ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Military Veterans ◽  
Motor Dysfunction
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