Adolescent voluntary exercise attenuated hippocampal innate immunity responses and depressive-like behaviors following maternal separation stress in male rats

2016 ◽  
Vol 163 ◽  
pp. 177-183 ◽  
Author(s):  
Mahsa Sadeghi ◽  
Maghsoud Peeri ◽  
Mir-Jamal Hosseini
Keyword(s):  
Innate Immunity ◽  
Maternal Separation ◽  
Voluntary Exercise ◽  
Male Rats

Sex dimorphic changes in Trh gene methylation and thyroid-axis response to energy demands in maternally-separated rats

Endocrinology ◽  
2021 ◽  
Author(s):  
Lorraine Jaimes-Hoy ◽  
Adrián Pérez-Maldonado ◽  
Elian Narváez Bahena ◽  
Natalia de la Cruz Guarneros ◽  
Adair Rodríguez-Rodríguez ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Binding Site ◽  
Fat Mass ◽  
Maternal Separation ◽  
Voluntary Exercise ◽  
Male Rats ◽  
Proximal Promoter ◽  
Basal Activity ◽  
Energy Demands ◽  
Hpt Axis

Abstract The hypothalamus-pituitary-thyroid (HPT) axis regulates energy balance through the pleiotropic action of thyroid hormones. HPT basal activity and stimulation by cold or voluntary exercise are repressed by previous chronic stress in adults. Maternal separation (MS) modifies HPT basal activity, we thus studied the response of the axis to energy demands and analyzed possible epigenetic changes on Trh promoter. Non-handled (NH) or MS male Wistar rats were cold exposed 1h at adulthood, only in NH rats Trh expression in the hypothalamic paraventricular nucleus (PVN) and serum TSH concentration were increased. Two weeks of voluntary exercise decreased fat mass, increased Trh expression, and thyroid hormones concentration changed proportionally to running distance in NH male rats and MS male rats. Although NH-females ran more than MS and much more than males, exercise decreased body weight and fat mass only in NH-rats with no change on any parameter of HPT axis, but increased Pomc expression in arcuate-nucleus of NH- whereas Npy in MS-females. Overall methylation pattern of PVN Trh gene promoter was similar in NH-males or -females; MS modified methylation of specific CpG sites, a thyroid-hormone receptor (THR) binding site present after the initiation site was hypomethylated in MS-males; in MS-females, the THR binding-site of the proximal promoter (site 4) and two sites in the first intron were hypermethylated. Our studies showed that, in a sex dimorphic manner, MS blunted the responses of HPT axis to energy demands in adult animals and caused methylation changes on Trh promoter that could alter T3 feedback.

Effects of Early Maternal Separation on Biobehavioral and Neuropathological Markers of Alzheimer's Disease in Adult Male Rats

2013 ◽  
Vol 10 (4) ◽  
pp. 420-432 ◽  
Author(s):  
Eva Martisova ◽  
Barbara Aisa ◽  
Gorka Guerenu ◽  
Maria Javier Ramirez
Keyword(s):  
Adult Male ◽  
Maternal Separation ◽  
Male Rats

The timing of maternal separation affects morris water maze performance and long-term potentiation in male rats

2013 ◽  
Vol 56 (5) ◽  
pp. 1102-1109 ◽  
Author(s):  
Xiujing Cao ◽  
Shenghai Huang ◽  
Jiejie Cao ◽  
Tingting Chen ◽  
Ping Zhu ◽  
...  
Keyword(s):  
Morris Water Maze ◽  
Water Maze ◽  
Maternal Separation ◽  
Long Term Potentiation ◽  
Male Rats ◽  
Maze Performance ◽  
Term Potentiation

scholarly journals Different Short-Term Mild Exercise Modalities Lead to Differential Effects on Body Composition in Healthy Prepubertal Male Rats

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
D. M. Sontam ◽  
M. H. Vickers ◽  
J. M. O’Sullivan ◽  
M. Watson ◽  
E. C. Firth
Keyword(s):  
Body Composition ◽  
Food Intake ◽  
Vital Role ◽  
Voluntary Exercise ◽  
Bone Architecture ◽  
Male Rats ◽  
Short Term ◽  
Cross Sectional ◽  
Impact Exercise ◽  
Prepubertal Rats

Physical activity has a vital role in regulating and improving bone strength. Responsiveness of bone mass to exercise is age dependent with the prepubertal period suggested to be the most effective stage for interventions. There is a paucity of data on the effects of exercise on bone architecture and body composition when studied within the prepubertal period. We examined the effect of two forms of low-impact exercise on prepubertal changes in body composition and bone architecture. Weanling male rats were assigned to control (CON), bipedal stance (BPS), or wheel exercise (WEX) groups for 15 days until the onset of puberty. Distance travelled via WEX was recorded, food intake measured, and body composition quantified. Trabecular and cortical microarchitecture of the femur were determined by microcomputed tomography. WEX led to a higher lean mass and reduced fat mass compared to CON. WEX animals had greater femoral cortical cross-sectional thickness and closed porosity compared to CON. The different exercise modalities had no effect on body weight or food intake, but WEX significantly altered body composition and femoral microarchitecture. These data suggest that short-term mild voluntary exercise in normal prepubertal rats can alter body composition dependent upon the exercise modality.

scholarly journals Effect of Voluntary Exercise Training on Corticosterone Level and Immobility Behavior Induced by Chronic Stress in Rats

2020 ◽  
Vol 6 (3) ◽  
pp. 164-169
Author(s):  
Zahra Entezari ◽  
◽  
Ayyub Babaei ◽  
Saleh Rahmati-Ahmadabad ◽  
◽  
...  
Keyword(s):  
Exercise Training ◽  
Chronic Stress ◽  
Exercise Group ◽  
Voluntary Exercise ◽  
Male Rats ◽  
Depression Symptoms ◽  
Chronic Unpredictable Stress ◽  
Corticosterone Concentration ◽  
Serum Corticosterone ◽  
Immobility Time

Background: Depression is a common mood disorder that in the long-term impairs thoughts, behavior, feelings, and health. Chronic unpredictable stress is one of the factors that can cause depression. Objectives: To investigate the effect of voluntary exercise training on immobility behavior (caused by chronic unpredictable stress) and serum corticosterone concentration. Materials & Methods: A total of 24 male rats were randomly and equally assigned to four groups of healthy-control, healthy-exercise, depressed-control, and depressed-exercise. Depressed-control and depressed-exercise groups were first exposed to three weeks of chronic unpredictable stress. After this period, the exercise groups performed four weeks of voluntary exercise training. Twentyfour hours after the last training session, a forced swim test was taken from the rats and their blood samples were taken 24 hours later. The obtained data were analyzed using a 2-way analysis of variance (significance level: P<0.05). The Pearson correlation coefficient was used to examine the relationship between study variables. All statistical analyses were performed in SPSS v. 22. Results: Chronic stress increased immobility behavior (P=0.001) and serum corticosterone concentration (P=0.001). In contrast, exercise training reduced immobility behavior (P=0.001) and serum corticosterone (P=0.001). The immobility time (P=0.001) and serum corticosterone concentration in the depressed-exercise group were higher than those in the healthy-exercise group (P=0.001). There was a positive correlation between immobility behavior and serum corticosterone concentration (r=0.85 and P=0.001). Conclusion: While the chronic stress increases the immobility behavior and serum corticosterone concentration, voluntary exercise training can reduce immobility behavior and serum corticosterone and adjust some depression symptoms.

scholarly journals Maternal separation enhances anticontractile perivascular adipose tissue function in male rats on a high-fat diet

2018 ◽  
Vol 315 (6) ◽  
pp. R1085-R1095 ◽  
Author(s):  
Analia S. Loria ◽  
Frank T. Spradley ◽  
Ijeoma E. Obi ◽  
Bryan K. Becker ◽  
Carmen De Miguel ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
High Fat Diet ◽  
Life Stress ◽  
Vascular Function ◽  
Maternal Separation ◽  
Male Rats ◽  
Protective Effects ◽  
Ang Ii ◽  
High Fat ◽  
Perivascular Adipose Tissue

Clinical studies have shown that obesity negatively impacts large arteries’ function. We reported that rats exposed to maternal separation (MatSep), a model of early life stress, display enhanced angiotensin II (ANG II)-induced vasoconstriction in aortic rings cleaned of perivascular adipose tissue (PVAT) under normal diet (ND) conditions. We hypothesized that exposure to MatSep promotes a greater loss of PVAT-mediated protective effects on vascular function and loss of blood pressure (BP) rhythm in rats fed a high-fat diet (HFD) when compared with controls. MatSep was performed in male Wistar-Kyoto rats from days 2 to 14 of life. Normally reared littermates served as controls. On ND, aortic rings from MatSep rats with PVAT removed showed increased ANG II-mediated vasoconstriction versus controls; however, rings from MatSep rats with intact PVAT displayed blunted constriction. This effect was exacerbated by an HFD in both groups; however, the anticontractile effect of PVAT was greater in MatSep rats. Acetylcholine-induced relaxation was similar in MatSep and control rats fed an ND, regardless of the presence of PVAT. HFD impaired aortic relaxation in rings without PVAT from MatSep rats, whereas the presence of PVAT improved relaxation in both groups. On an HFD, immunolocalization of vascular smooth muscle-derived ANG-(1–7) and PVAT-derived adiponectin abundances were increased in MatSep. In rats fed an HFD, 24-h BP and BP rhythms were similar between groups. In summary, MatSep enhanced the ability of PVAT to blunt the heightened ANG II-induced vasoconstriction and endothelial dysfunction in rats fed an HFD. This protective effect may be mediated via the upregulation of vasoprotective factors within the adipovascular axis.

scholarly journals Voluntary Exercise Rescues the Spatial Memory Deficit Associated With Early Life Isoflurane Exposure in Male Rats

2019 ◽  
Vol 129 (5) ◽  
pp. 1365-1373 ◽  
Author(s):  
Gregory A. Chinn ◽  
Jennifer M. Sasaki Russell ◽  
Esther T. Banh ◽  
Saehee C. Lee ◽  
Jeffrey W. Sall
Keyword(s):  
Spatial Memory ◽  
Early Life ◽  
Memory Deficit ◽  
Voluntary Exercise ◽  
Male Rats ◽  
Spatial Memory Deficit
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