In tribute to Bob Blanchard: Divergent behavioral phenotypes of 16p11.2 deletion mice reared in same-genotype versus mixed-genotype cages

2015 ◽  
Vol 146 ◽  
pp. 16-27 ◽  
Author(s):  
Mu Yang ◽  
Freeman Lewis ◽  
Gillian Foley ◽  
Jacqueline N. Crawley
Keyword(s):  
Behavioral Phenotypes ◽  
Mixed Genotype ◽  
Genotype Versus

scholarly journals Extended Reproductive Roles of the fruitless Gene in Drosophila melanogaster Revealed by Behavioral Analysis of New fru Mutants

Genetics ◽  
1997 ◽  
Vol 147 (3) ◽  
pp. 1107-1130 ◽  
Author(s):  
Adriana Villella ◽  
Donald A Gailey ◽  
Barbra Berwald ◽  
Saiyou Ohshima ◽  
Phillip T Barnes ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Sex Determination ◽  
Molecular Genetics ◽  
Behavioral Analysis ◽  
Behavioral Phenotypes ◽  
New Mutations

The fruitless mutants fru3 and fru4 were assessed for sex-specific reproductive-behavioral phenotypes and compared to the previously reported fru mutants. Among the several behavioral anomalies exhibited by males expressing these relatively new mutations, some are unique. fru3 and fru4 males are less stimulated to court females than and fru1 and fru2. No courtship pulse song is generated by either fru3 or fru4 males, even though they perform brief wing extensions. fru3 and fru4 males display significantly less chaining behavior than do fru1 males. The hierarchy of courtship responses by fru males directed toward females vs. males, when presented with both sexes simultaneously, is that fru1 males perform vigorous and indiscriminant courtship directed at either sex; fru4 males are similarly indiscriminant, but courtship levels were lower than fru1; fru2 males prefer females; fru3 males show a courtship bias toward males. fru3 and fru4 males essentially lack the Muscle of Lawrence (MOL). On several reproductive criteria, there was no difference between fru-variant females and fru  +. The increases in phenotypic severity measured for the new mutants are discussed in the context of the emerging molecular genetics of fru and with regard to the gene's position within the sex-determination pathway.

Association of Behavioral Phenotypes With Changes in Sleep During a Workplace Wellness Program

2021 ◽  
pp. 089011712110150
Author(s):  
Kimberly J. Waddell ◽  
Sujatha Changolkar ◽  
Gregory Szwartz ◽  
Sarah Godby ◽  
Mitesh S. Patel
Keyword(s):  
Physical Activity ◽  
Sleep Duration ◽  
Physical Activity Intervention ◽  
Secondary Analysis ◽  
The United States ◽  
Behavioral Phenotype ◽  
Workplace Wellness ◽  
Wellness Program ◽  
Behavioral Phenotypes ◽  
Physically Active

Purpose: Examine changes in sleep duration by 3 behavioral phenotypes during a workplace wellness program with overweight and obese adults. Design: Secondary analysis of a randomized clinical trial Setting: Remotely monitored intervention conducted across the United States Subjects: 553 participants with a body mass index ≥25 Intervention: Participants were randomized to 1 of 4 study arms: control, gamification with support, gamification with collaboration, and gamification with competition to increase their physical activity. All participants were issued a wrist-worn wearable device to record their daily physical activity and sleep duration. Measures: The primary outcome was change in daily sleep duration from baseline during the 24 week intervention and follow-up period by study arm within behavioral phenotype class. Analysis: Linear mixed effects regression. Results: Participants who had a phenotype of less physically active and less social at baseline, in the gamification with collaboration arm, significantly increased their sleep duration during the intervention period (30.2 minutes [95% CI 6.9, 53.5], P = 0.01), compared to the control arm. There were no changes in sleep duration among participants who were more extroverted and motivated or participants who were less motivated and at-risk. Conclusions: Changes in sleep during a physical activity intervention varied by behavioral phenotype. Behavioral phenotypes may help to precisely identify who is likely to improve sleep duration during a physical activity intervention.

scholarly journals The level of GNE and its relationship with behavioral phenotypes in children with autism spectrum disorder

Medicine ◽  
2020 ◽  
Vol 99 (28) ◽  
pp. e21013
Author(s):  
Xiaolei Yang ◽  
Hongjie Li ◽  
Jie Ge ◽  
Hong Chao ◽  
Gang Li ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Behavioral Phenotypes

Genetic analysis of dyslexia and other complex behavioral phenotypes

1997 ◽  
Vol 9 (6) ◽  
pp. 636-641 ◽  
Author(s):  
Bruce F. Pennington ◽  
Shelley D. Smith
Keyword(s):  
Genetic Analysis ◽  
Behavioral Phenotypes

scholarly journals Developmental and behavioral phenotypes in a mouse model of DDX3X syndrome

2021 ◽  
Author(s):  
Andrea Boitnott ◽  
Marta Garcia-Forn ◽  
Dévina C. Ung ◽  
Kristi Niblo ◽  
Danielle Mendonca ◽  
...  
Keyword(s):  
Mouse Model ◽  
Behavioral Phenotypes
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