Further analysis of behavioral and endocrine consequences of chronic exposure of male Wistar rats to subtoxic doses of endocrine disruptor chlorobenzenes

2011 ◽  
Vol 103 (5) ◽  
pp. 421-430 ◽  
Author(s):  
Z. Valkusz ◽  
G. Nagyéri ◽  
M. Radács ◽  
T. Ocskó ◽  
P. Hausinger ◽  
...  
Keyword(s):  
Chronic Exposure ◽  
Endocrine Disruptor ◽  
Wistar Rats ◽  
Male Wistar Rats

scholarly journals Reproductive effects of the psychoactive beverage ayahuasca in male Wistar rats after chronic exposure

2017 ◽  
Vol 27 (3) ◽  
pp. 353-360 ◽  
Author(s):  
Alana de Fátima Andrade Santos ◽  
Ana Luiza Sarkis Vieira ◽  
Aline Pic-Taylor ◽  
Eloisa Dutra Caldas
Keyword(s):  
Chronic Exposure ◽  
Wistar Rats ◽  
Reproductive Effects ◽  
Male Wistar Rats

scholarly journals Implication of Acute, Sub-chronic and Chronic Exposure to Different Pesticides via Inhalation on Male Wistar Rats

2017 ◽  
Vol 5 (4) ◽  
pp. 74-85
Author(s):  
Oluwatoyin Taiwo Adeoti ◽  
Donatus Chuka Belonwu ◽  
Mathew Owhonda Wegwu ◽  
Justice Obinna Osuoha
Keyword(s):  
Chronic Exposure ◽  
Wistar Rats ◽  
Male Wistar Rats

Terbufos sulfone aggravates kidney damage in STZ-induced diabetic rats

Biologia ◽  
2017 ◽  
Vol 72 (8) ◽  
Author(s):  
Syed Muhammad Nurulain ◽  
Shreesh Ojha ◽  
Mohamed Shafiullah ◽  
Javed Yasin ◽  
Tayyaba Yasmin ◽  
...  
Keyword(s):  
Body Weight ◽  
Chronic Exposure ◽  
Wistar Rats ◽  
Organophosphorus Compounds ◽  
Lethal Dose ◽  
Diabetic Rats ◽  
Kidney Damage ◽  
Male Wistar Rats ◽  
The Impact

AbstractThe consequences of chronic exposure of organophosphorus compounds (OPCs) on diabetic subjects have been seldom reported. The aim of the present study was to assess the impact of non-lethal dose of terbufos sulfone (TS), an organophosphate, on the kidney of non-diabetic and streptozotocin (STZ)- induced diabetic rats. The diabetogenic effect of TS was also examined. Male Wistar rats were treated for two weeks with 130 µg/kg body weight/day of TS. This dose was 1/20 of LD

Effects of sub-chronic exposure to palladium (as potassium hexachloro-palladate) on cytokines in male Wistar rats

2008 ◽  
Vol 27 (6) ◽  
pp. 493-497 ◽  
Author(s):  
I Iavicoli ◽  
G Carelli ◽  
A Marinaccio ◽  
L Fontana ◽  
EJ Calabrese
Keyword(s):  
Chronic Exposure ◽  
Wistar Rats ◽  
Statistical Significance ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Mean Values ◽  
Male Wistar Rats ◽  
The Difference

Palladium (Pd) is a heavy metal belonging to the platinum group elements. It has been shown that Pd and its compounds can cause sensitization, asthma and dermatologic disorders. In this study, Wistar rats were exposed for 3 months to 0, 1, 10, 100, and 250 ng/ml of Pd (as potassium hexachloro-palladate) in drinking water. At the end of exposure, possible changes in two type-1 cytokines [interleukin (IL)-2, interferon (INF)-γ] and one type-2 cytokine (IL-4) in the serum were measured. After the sub-chronic exposure, analysis of variance of IL-2 and INF-γ response shows that the difference between mean values in the groups of animals exposed reaches statistical significance for IL-2 ( P = 0.001), showing a J-shaped dose–response relationship. At the higher dose of 250 ng/ml Pd, it was observed a significant increase in IL-2 production when compared with the controls. Furthermore at 1 and 10 ng/ml of Pd we observed an increase of INF-γ production that was significant at 100 ng/ml of Pd, while at the higher dose of 250 ng/ml of Pd the response was indistinguishable from the control. At the doses investigated, Pd has been shown not to determine a modification of IL-4 response ( P = 0.10). These preliminary findings indicate the need to carry out further investigations regarding the effect of other Pd compounds and the measurement of other types of cytokines both in the animal model used in our study and other models.

scholarly journals Hepatic and reproductive toxicity of sub-chronic exposure to dichlorvos and lead acetate on male Wistar rats

2020 ◽  
Vol 9 (6) ◽  
pp. 283
Author(s):  
WahabAdekunle Oyeyemi ◽  
Oore-oluwapoOlolade Daramola ◽  
AdeniranOluwadamilare Akinola ◽  
AdeoyeOyewole Idris ◽  
Ikponmwosa Aikpitanyi
Keyword(s):  
Lead Acetate ◽  
Chronic Exposure ◽  
Wistar Rats ◽  
Reproductive Toxicity ◽  
Male Wistar Rats

Diuron exposure induces systemic and organ-specific toxicity following acute and sub-chronic exposure in male Wistar rats

2011 ◽  
Vol 31 (3) ◽  
pp. 387-396 ◽  
Author(s):  
Alexandre Domingues ◽  
Luis Fernando Barbisan ◽  
Priscila Raquel Martins ◽  
Ana Lúcia Tozzi Spinardi-Barbisan
Keyword(s):  
Chronic Exposure ◽  
Wistar Rats ◽  
Organ Specific ◽  
Male Wistar Rats

scholarly journals Effects of chronic exposure to lead, cadmium, and manganese mixtures on oxidative stress in rat liver and heart / Utjecaj kronične istodobne izloženosti olovu, kadmiju i manganu na oksidativni stres u jetri i srcu štakora

2015 ◽  
Vol 66 (1) ◽  
pp. 51-62 ◽  
Author(s):  
Iwona Markiewicz-Górka ◽  
Lidia Januszewska ◽  
Aleksandra Michalak ◽  
Adam Prokopowicz ◽  
Ewa Januszewska ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Drinking Water ◽  
Liver Function ◽  
Chronic Exposure ◽  
Wistar Rats ◽  
Combined Exposure ◽  
Bilirubin Concentration ◽  
Animal Group ◽  
Male Wistar Rats ◽  
Alt Activity

Abstract The aim of this study was to assess the effects of chronic combined exposure to low, environmental doses of Cd, Pb, and Mn on oxidative stress in the liver and heart of rats and on their liver function parameters. Male Wistar rats were divided randomly into eight groups. For nine months controls were receiving drinking water alone, whereas the exposed groups were receiving drinking water with Pb (0.2 mg L-1), Cd (1 mg L-1), and Mn (2 mg L-1) alone or in combinations. Malondialdehyde (MDA) significantly increased in both heart and liver of the animals after combined exposure to metals. Heart MDA correlated with blood Cd, Pb, and Mn and liver MDA with blood Cd. Aspartate aminotransferase (AST) activity and bilirubin concentration also increased significantly in the animal group exposed to all three metals and correlated positively with blood Cd, Pb, and Mn. Our study has confirmed the synergistic effect of the Cd, Mn, and Pb combination on the increase in heart MDA. A similar synergy was observed for Pb+Mn in the increase of serum alanine aminotransferase (ALT) activity as an indicator of liver function.

scholarly journals Differences in adrenal steroid hormones production in pubertal rats exposed to low doses of endocrine disruptor DDT during prenatal and postnatal development

2017 ◽  
Vol 63 (4) ◽  
pp. 306-311 ◽  
Author(s):  
N.V. Yaglova ◽  
D.A. Tsomartova ◽  
V.V. Yaglov
Keyword(s):  
Postnatal Development ◽  
Steroid Hormones ◽  
Endocrine Disruptor ◽  
Wistar Rats ◽  
Zona Glomerulosa ◽  
Low Doses ◽  
Adrenal Steroid ◽  
Steroid Profile ◽  
Male Wistar Rats ◽  
Circulatory Disorders

Production of adrenal steroid hormones in pubertal male Wistar rats exposed to low doses of DDT during both prenatal and postnatal and only postnatal development was evaluated. Altered production of all types of steroid hormones and serum steroid profile with opposite changes in rats exposed prenatally and postnatally, and only postnatally was found. The study showed that daily exposure to low doses of DDT enhanced conversion of progesterone to 17OH-progesterone and did not exert selective antiandrogenic or proestrogenic action unlike effect of toxic and subtoxic doses. Impaired morphogenesis of the adrenal cortex and circulatory disorders in zona glomerulosa contributed to reduced aldosterone and sex steroid hormones production.

scholarly journals Antioxidant Effects of Red Fruit Oil on MMP-1 Gene Expression and Malondialdehyde Levels on Skin Exposed to UVB Rays

2019 ◽  
Vol 3 (2) ◽  
pp. 100
Author(s):  
Monita Sugianto ◽  
Achadiyani Achadiyani ◽  
Gaga Irawan Nugraha
Keyword(s):  
Chronic Exposure ◽  
Wistar Rats ◽  
Beta Carotene ◽  
Oxygen Species ◽  
Not Given ◽  
Male Wistar Rats ◽  
Ros Formation ◽  
Fruit Oil ◽  
Antioxidant Effects ◽  
Β Carotene

Background: Chronic exposure ultraviolet (UV)-B radiation causes reactive oxygen species (ROS) formation. Furthermore, ROS will induce the formation of malondialdehyde and increase matrix metalloproteinase (MMP)-1 expression. One strategy against the free radicals effects is by consuming antioxidants. This study aims to analyze the antioxidants effect of red fruit oil (RFO) on MMP-1 expression and malondialdehyde levels due to exposure to UVB rays.Materials and Methods: Thirty male Wistar rats were divided into 5 groups. The P0 group was not given treatment, the P1 group was only exposed to UVB light, the P2 group was exposed to UVB light and given 0.5 mL/200 g body weight (BW) of RFO, the P3 group was exposed to UVB light and given 1 mL/200 g BW of RFO, and group P4 exposed to UVB rays and given 2 mL/200 g BW of RFO. Experimental animals would be examined for MMP-1 expression and malondialdehyde level. RFO would be identified with β-carotene and tocopherol content.Results: Beta-carotene and tocopherol were detected in RFO. RFO reduced significantly MMP-1 expression (p<0.05) in P2 group (0.73±1.27), P3 group (0.63±0.95), P4 group (9.56±20.97) compared group P1 (48.07±65.58). However, RFO did not reduce malondialdehyde levels (p>0.05).Conclusion: Our research demonstrates RFO containing tocopherol and β-carotene can reduce the MMP-1 expression, but does not affect malondialdehyde levels due to exposure to UVB rays. An effective dose that can reduce malondialdehyde levels and MMP-1 expression is 1 mL/200 g BW.Keywords: red fruit oil, antioxidant, skin, MMP-1 expression, malondialdehyde, UVB rays, photoaging 

scholarly journals Developmental and Reproductive Outcomes in Male Rats Exposed to Triclosan: Two-Generation Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Bruno Garcia Montagnini ◽  
Simone Forcato ◽  
Karine Vandressa Pernoncine ◽  
Mariana Cunha Monteiro ◽  
Marina Rangel Ferro Pereira ◽  
...  
Keyword(s):  
Endocrine Disruptor ◽  
Wistar Rats ◽  
Corn Oil ◽  
Sperm Quality ◽  
Male Rats ◽  
Control Group ◽  
Sperm Viability ◽  
Male Wistar Rats ◽  
Reproduction Toxicity ◽  
Environmental Compartments

Triclosan (TCS) is a phenolic compound with broad-spectrum antimicrobial action that has been incorporated into a variety of personal care products and other industry segments such as toys, textiles, and plastics. Due to its widespread use, TCS and its derivatives have been detected in several environmental compartments, with potential bioaccumulation and persistence. Indeed, some studies have demonstrated that TCS may act as a potential endocrine disruptor for the reproductive system. In the current study, we are reporting on the results obtained for male rats after a two-generation reproduction toxicity study conducted with TCS. Female and male Wistar rats were treated daily by gavage with TCS at doses of 0.8, 2.4, and 8.0 mg/kg/day or corn oil (control group) over 10 weeks (F0) and over 14 weeks (F1) before mating and then throughout mating, until weaning F2 generations, respectively. TCS exposure decreased sperm viability and motility of F1 rats at the dose of 2.4 mg/kg. The effects of TCS on sperm quality may be related to the exposure window, which includes the programming of reproductive cells that occurs during fetal/neonatal development.

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