Dose-dependent cocaine place conditioning and D1 dopamine antagonist effects in male Japanese quail

2004 ◽  
Vol 82 (2-3) ◽  
pp. 309-315 ◽  
Author(s):  
C AKINS ◽  
N LEVENS ◽  
R PRATHER ◽  
B COOPER ◽  
T FRITZ
Keyword(s):  
Japanese Quail ◽  
Dopamine Antagonist ◽  
Place Conditioning ◽  
Dose Dependent

LUTEINIZING HORMONE RELEASING FACTOR IN THE QUAIL HYPOTHALAMUS

1972 ◽  
Vol 53 (1) ◽  
pp. 131-138 ◽  
Author(s):  
P. M. SMITH ◽  
B. K. FOLLETT
Keyword(s):  
Luteinizing Hormone ◽  
Japanese Quail ◽  
Release Rate ◽  
Initial Period ◽  
Repetitive Stimulation ◽  
Pituitary Glands ◽  
Lh Release ◽  
A Minor ◽  
Dose Dependent ◽  
Stimulation Of

SUMMARY Pituitaries from Japanese quail were superfused continuously for up to 12 h and the luteinizing hormone (LH) in the superfusate was measured by radioimmunoassay. After an initial period the release rate remained low and relatively constant. The introduction of hypothalamic extracts prepared from quail substantially increased immunoreactive LH release. The responses were dose-dependent. Cortical extracts caused a minor but significant response. Dopamine was inactive in the system. The technique is attractive because it allows for repetitive stimulation of the same pituitary glands with treatments being administered every 30–45 min.

scholarly journals Repeated subcutaneous administration of PT150 has dose-dependent effects on sign tracking in male Japanese quail.

2019 ◽  
Vol 27 (6) ◽  
pp. 515-521 ◽  
Author(s):  
Beth Ann Rice ◽  
Meredith A. Saunders ◽  
Julia E. Jagielo-Miller ◽  
Mark A. Prendergast ◽  
Chana K. Akins
Keyword(s):  
Japanese Quail ◽  
Subcutaneous Administration ◽  
Sign Tracking ◽  
Dose Dependent

scholarly journals Noradrenergic alpha-2A receptor activation suppresses courtship vocalization in male Japanese quail.

2021 ◽  
Author(s):  
Yasuko Tobari ◽  
Ami Masuzawa ◽  
Norika Harada ◽  
Kenta Suzuki ◽  
Simone Meddle
Keyword(s):  
Japanese Quail ◽  
High Frequency ◽  
Adrenergic Receptor ◽  
Receptor Activation ◽  
Early Gene ◽  
Intracerebroventricular Injection ◽  
Receptor Mrna ◽  
Noradrenergic Innervation ◽  
Dose Dependent ◽  
Stimulation Of

Male Japanese quail produce high-frequency crow vocalizations to attract females during the breeding season. The nucleus of intercollicularis (ICo) is the midbrain vocal center in birds and electrical stimulation of the ICo produces calls that include crowing. Noradrenaline plays a significant role in sexual behavior but the contribution of noradrenaline in the control of courtship vocalizations in quail has not been well established. Using dose-dependent intracerebroventricular injection of clonidine, an α2-adrenergic receptor-specific agonist, crowing vocalization was immediately suppressed. At the same time as crow suppression by clonidine there was a reduction of immediate early gene, zenk mRNA, in the ICo; no zenk mRNA expression was detected in the dorsomedial division of the nucleus. Using histochemistry, we determined that the ICo receives noradrenergic innervation and expresses α2A-adrenergic receptor mRNA. Taken together, these data suggest that noradrenaline regulates courtship vocalization in quail, possibly via the alpha2A-adrenergic receptor expressed on ICo neurons.

scholarly journals Conditioned increase of locomotor activity induced by haloperidol

2018 ◽  
Author(s):  
Luis G. De la Casa ◽  
Lucía Carcel ◽  
Juan C. Ruiz-Salas ◽  
Lucía Vicente ◽  
Auxiliadora Mena
Keyword(s):  
Locomotor Activity ◽  
Conditioned Stimulus ◽  
Classical Conditioning ◽  
Dopamine Antagonist ◽  
Contextual Cues ◽  
Dopaminergic Activity ◽  
Conditioning Experiment ◽  
D2 Antagonist ◽  
Dose Dependent Increase ◽  
Dose Dependent

AbstractDopamine antagonist drugs have profound effects on locomotor activity. In particular, the administration of the D2 antagonist haloperidol produces a state that is similar to catalepsy. In order to confirm whether the modulation of the dopaminergic activity produced by haloperidol can act as an unconditioned stimulus, we carried out two experiments in which the administration of haloperidol was repeatedly paired with the presence of distinctive contextual cues that served as a Conditioned Stimulus. Paradoxically, the results revealed a dose-dependent increase in locomotor activity following conditioning with dopamine antagonist (Experiments 1) that was susceptible of extinction when the conditioned stimulus was presented repeatedly by itself after conditioning (Experiment 2). These data are interpreted from an associative perspective, considering them as a result of a classical conditioning process.

Place conditioning with morphine and phencyclidine: Dose dependent effects

Life Sciences ◽  
1985 ◽  
Vol 36 (4) ◽  
pp. 363-368 ◽  
Author(s):  
Gordon A. Barr ◽  
William Paredes ◽  
Wagner H. Bridger
Keyword(s):  
Place Conditioning ◽  
Dose Dependent

The effect of microinjection of CART 55-102 into the nucleus accumbens shell on morphine-induced conditioned place preference in rats: Involvement of the NMDA receptor

2020 ◽  
Author(s):  
Atefeh Bakhtazad ◽  
Nasim Vousooghi ◽  
Mohammad Nasehi ◽  
Nima Sanadgol ◽  
Behzad Garmabi ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Nmda Receptor ◽  
Conditioned Place Preference ◽  
Place Preference ◽  
Place Conditioning ◽  
Nucleus Accumbens Shell ◽  
Nmda Glutamate Receptor ◽  
Reward Pathway ◽  
Dose Dependent Increase ◽  
Dose Dependent

Abstract Background The addictive properties of opioids may be mediated to some extent by cocaine- and amphetamine-regulated transcript (CART) in the reward pathway. There are also some claims regarding the interaction of CART and glutamate system. Drug-paired learning and memory may induce conditioned place preference (CPP) or conditioned place aversion (CPA). Here, we have evaluated whether intra-nucleus accumbens (NAc) shell infusions of CART induces CPP or CPA and affect morphine reward. In addition, we have measured the expression of the NR1 subunit of the N-methyl-D-aspartate (NMDA) glutamate receptor in various parts of the reward pathway (NAc, prefrontal cortex (PFC), and hippocampus) after conditioning tests. Bilateral cannulas were implanted in the rats NAc shell and then the animals were exposed to place conditioning. Animals were place-conditioned with several doses of subcutaneous (s.c.) morphine prior to the intra-NAc shell infusion of artificial cerebral spinal fluid (aCSF). Immunohistochemistry (IHC) data showed a dose-dependent increase in the expression of the NR1 subunit in all examined parts. Then, rats were conditioned with intra-NAc shell infusion of different doses of CART. CPP and CPA were induced with 2.5 and 5 μg/side, respectively.Results IHC showed an elevated level of NR1 with 2.5 μg/side and a decrease with 5 μg/side in all areas. Administration of a sub-rewarding dose of CART (1.25 μg/side) prior to the injection of a sub-rewarding dose of morphine (2.5 mg/kg) induced CPP and IHC analysis showed an increased amount of NR1 in all examined tissues. However, infusion of an aversive dose of CART (5 μg/side) prior to the injection of a rewarding dose of morphine (5 mg/kg) produced neither CPP nor CPA and IHC data showed a significant decrease in the amount of NR1 subunit in the NAc and hippocampus.Conclusions It seems that the rewarding or aversive effects of intra-NAc shell CART and its facilitating or inhibiting effects on morphine reward are dose-dependent. Furthermore, the NMDA receptor may be closely involved in the affective properties of opioids and CART in the reward pathway.

Dose-dependent aversive and rewarding effects of amphetamine as revealed by a new place conditioning apparatus

1996 ◽  
Vol 125 (1) ◽  
pp. 92-96 ◽  
Author(s):  
S. Cabib ◽  
S. Puglisi-Allegra ◽  
C. Genua ◽  
H. Simon ◽  
M. Le Moal ◽  
...  
Keyword(s):  
Place Conditioning ◽  
Dose Dependent ◽  
Conditioning Apparatus

The effects of different doses of pimozide and [D-Ala6, Pro9-N ethylamide]-LHRH (LHRH-A) on gonadotropin release and ovulation in female goldfish

1985 ◽  
Vol 63 (6) ◽  
pp. 1252-1256 ◽  
Author(s):  
M. Sokolowska ◽  
R. E. Peter ◽  
C. S. Nahorniak
Keyword(s):  
Body Weight ◽  
Dopamine Antagonist ◽  
Dose Dependency ◽  
Maximum Serum ◽  
Luteinizing Hormone Releasing Hormone ◽  
Gonadotropin Release ◽  
Serum Gonadotropin ◽  
Dose Dependent ◽  
Late Stages ◽  
Different Doses

Female goldfish, in late stages of ovarian recrudescence, held at 12 or 20 °C, were injected with a range of dosages of the dopamine antagonist pimozide, at 10, 1, and 0.1 μg/g body weight, to block the endogenous gonadotropin release inhibitory activity of dopamine, and 3 h later were injected with [D-Ala6, Pro9-N ethylamide]-luteinizing hormone-releasing hormone (LHRH-A), at 0.1 μg/g body weight, after which serum gonadotropin levels were determined. The results demonstrate the dose dependency of pimozide in potentiating the activity of LHRH-A. In a second set of experiments, using female goldfish in a preovulatory condition, held at 12 and 20 °C, the changes in serum gonadotropin levels and frequency of ovulation were determined following injection of pimozide, at 1 μg/g body weight, and LHRH-A, at 0.1, 0.01, and 0.001 μg/g body weight. The results demonstrate that pimozide potentiates a dose-dependent response to LHRH-A. The maximum serum GtH levels found in response to the same dosages of pimozide and LHRH-A at 12 and 20 °C were similar; however, the maximum levels occurred earlier at 20 °C (6 h postinjections) than at 12 °C (24 h postinjections). Notably, only the combination of pimozide at 1 μg/g body weight and LHRH-A at 0.1 μg/g body weight, in fish at 20 °C, was highly effective in inducing ovulation.

Dose-dependent effects of the D3-preferring agonist 7-OH-DPAT on motor behaviors and place conditioning

1995 ◽  
Vol 122 (4) ◽  
pp. 351-357 ◽  
Author(s):  
T. V. Khroyan ◽  
D. A. Baker ◽  
J. L. Neisewander
Keyword(s):  
Place Conditioning ◽  
Motor Behaviors ◽  
Dose Dependent

scholarly journals Effect of large dietary doses of ß-carotene on plasma retinoid AND ß-carotene levels and ON progesterone production in the granulosa cells of Japanese quail

2000 ◽  
Vol 48 (1) ◽  
pp. 81-87 ◽  
Author(s):  
Gabriella Ágota ◽  
L. Bárdos ◽  
A. Pusztai
Keyword(s):  
Japanese Quail ◽  
Granulosa Cells ◽  
Basal Diet ◽  
Retinyl Palmitate ◽  
Control Group ◽  
Dependent Manner ◽  
Blood Samples ◽  
Progesterone Secretion ◽  
Dose Dependent ◽  
Control Group Group

An experiment was conducted to study the effect of large-dose (-carotene supplementation on blood retinoid and (-carotene levels as well as on the progesterone secretion of the granulosa cells in Japanese quail. Laying quails were assigned to three dietary groups. The control group (Group C) received the basal diet (laying feed containing 9000 IU vitamin A/kg). In the treated groups (Groups BC1 and BC2) the basal diet was supplemented with 102and 103mg/kg (-carotene (BC), respectively. At the end of the two-week feeding period, 10 birds from each group were euthanised. Blood samples were analysed for retinol, retinyl palmitate and (-carotene concentrations. Granulosa cells were isolated from ovarian follicles (F1and F2), and PMSG-inducedin vitroprogesterone (P4) secretion was measured. Similar retinol concentrations were found in both (-carotene supplemented groups, indicating saturation of the retinol-transporting system. (-carotene supplementation was accompanied by hypercarotenaemia, but did not increase the retinyl palmitate levels in the blood. PMSG-induced P4production of the granulosa cells decreased significantly in Groups BC1 and BC2 in a dose-dependent manner.

Sign in / Sign up

Export Citation Format

Share Document