Dose-dependent aversive and rewarding effects of amphetamine as revealed by a new place conditioning apparatus

1996 ◽  
Vol 125 (1) ◽  
pp. 92-96 ◽  
Author(s):  
S. Cabib ◽  
S. Puglisi-Allegra ◽  
C. Genua ◽  
H. Simon ◽  
M. Le Moal ◽  
...  
Keyword(s):  
Place Conditioning ◽  
Dose Dependent ◽  
Conditioning Apparatus

Place conditioning with morphine and phencyclidine: Dose dependent effects

Life Sciences ◽  
1985 ◽  
Vol 36 (4) ◽  
pp. 363-368 ◽  
Author(s):  
Gordon A. Barr ◽  
William Paredes ◽  
Wagner H. Bridger
Keyword(s):  
Place Conditioning ◽  
Dose Dependent

The effect of microinjection of CART 55-102 into the nucleus accumbens shell on morphine-induced conditioned place preference in rats: Involvement of the NMDA receptor

2020 ◽  
Author(s):  
Atefeh Bakhtazad ◽  
Nasim Vousooghi ◽  
Mohammad Nasehi ◽  
Nima Sanadgol ◽  
Behzad Garmabi ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Nmda Receptor ◽  
Conditioned Place Preference ◽  
Place Preference ◽  
Place Conditioning ◽  
Nucleus Accumbens Shell ◽  
Nmda Glutamate Receptor ◽  
Reward Pathway ◽  
Dose Dependent Increase ◽  
Dose Dependent

Abstract Background The addictive properties of opioids may be mediated to some extent by cocaine- and amphetamine-regulated transcript (CART) in the reward pathway. There are also some claims regarding the interaction of CART and glutamate system. Drug-paired learning and memory may induce conditioned place preference (CPP) or conditioned place aversion (CPA). Here, we have evaluated whether intra-nucleus accumbens (NAc) shell infusions of CART induces CPP or CPA and affect morphine reward. In addition, we have measured the expression of the NR1 subunit of the N-methyl-D-aspartate (NMDA) glutamate receptor in various parts of the reward pathway (NAc, prefrontal cortex (PFC), and hippocampus) after conditioning tests. Bilateral cannulas were implanted in the rats NAc shell and then the animals were exposed to place conditioning. Animals were place-conditioned with several doses of subcutaneous (s.c.) morphine prior to the intra-NAc shell infusion of artificial cerebral spinal fluid (aCSF). Immunohistochemistry (IHC) data showed a dose-dependent increase in the expression of the NR1 subunit in all examined parts. Then, rats were conditioned with intra-NAc shell infusion of different doses of CART. CPP and CPA were induced with 2.5 and 5 μg/side, respectively.Results IHC showed an elevated level of NR1 with 2.5 μg/side and a decrease with 5 μg/side in all areas. Administration of a sub-rewarding dose of CART (1.25 μg/side) prior to the injection of a sub-rewarding dose of morphine (2.5 mg/kg) induced CPP and IHC analysis showed an increased amount of NR1 in all examined tissues. However, infusion of an aversive dose of CART (5 μg/side) prior to the injection of a rewarding dose of morphine (5 mg/kg) produced neither CPP nor CPA and IHC data showed a significant decrease in the amount of NR1 subunit in the NAc and hippocampus.Conclusions It seems that the rewarding or aversive effects of intra-NAc shell CART and its facilitating or inhibiting effects on morphine reward are dose-dependent. Furthermore, the NMDA receptor may be closely involved in the affective properties of opioids and CART in the reward pathway.

Dose-dependent effects of the D3-preferring agonist 7-OH-DPAT on motor behaviors and place conditioning

1995 ◽  
Vol 122 (4) ◽  
pp. 351-357 ◽  
Author(s):  
T. V. Khroyan ◽  
D. A. Baker ◽  
J. L. Neisewander
Keyword(s):  
Place Conditioning ◽  
Motor Behaviors ◽  
Dose Dependent

scholarly journals Caenorhabditis Elegans Exhibits Morphine Addiction-like Behavior via the Opioid-like Receptor NPR-17

2022 ◽  
Vol 12 ◽  
Author(s):  
Soichiro Ide ◽  
Hirofumi Kunitomo ◽  
Yuichi Iino ◽  
Kazutaka Ikeda
Keyword(s):  
Caenorhabditis Elegans ◽  
Place Conditioning ◽  
Deficient Mutant ◽  
Chronic Morphine ◽  
C Elegans ◽  
Disease States ◽  
Morphine Addiction ◽  
Societal Problem ◽  
Invertebrate Model ◽  
Dose Dependent

Addiction has become a profound societal problem worldwide, and few effective treatments are available. The nematode Caenorhabditis elegans (C. elegans) is an excellent invertebrate model to study neurobiological disease states. C. elegans reportedly developed a preference for cues that had previously been paired with addictive drugs, similar to place conditioning findings in rodents. Moreover, several recent studies discovered and reported the existence of an opioid-like system in C. elegans. Still unclear, however, is whether C. elegans exhibits addictive-like behaviors for opioids, such as morphine. In the present study, we found that C. elegans exhibited dose-dependent preference for morphine using the conditioned chemosensory-cue preference (CCP) test. This preference was blocked by co-treatment with the opioid receptor antagonist naloxone. C. elegans also exhibited aversion to naloxone-precipitated withdrawal from chronic morphine exposure. The expression of morphine-induced CCP and morphine withdrawal were abolished in worms that lacked the opioid-like receptor NPR-17. Dopamine-deficient mutant (cat-2 (e1112)) worms also did not exhibit morphine-induced CCP. These results indicate that the addictive function of the opioid system exists in C. elegans, which may serve as a useful model of opioid addiction.

Dose-dependent and baseline-dependent conditioning with d-amphetamine in the place conditioning paradigm

1989 ◽  
Vol 99 (2) ◽  
pp. 244-247 ◽  
Author(s):  
N. L. Costello ◽  
J. N. Carlson ◽  
S. D. Glick ◽  
M. Bryda
Keyword(s):  
Place Conditioning ◽  
Conditioning Paradigm ◽  
Dose Dependent

scholarly journals Extinction of conditioned opiate withdrawal in rats in a two-chambered place conditioning apparatus

2012 ◽  
Vol 7 (3) ◽  
pp. 517-526 ◽  
Author(s):  
Karyn M Myers ◽  
Anita J Bechtholt-Gompf ◽  
Brian R Coleman ◽  
William A Carlezon
Keyword(s):  
Opiate Withdrawal ◽  
Place Conditioning ◽  
Conditioning Apparatus

Dose-dependent cocaine place conditioning and D1 dopamine antagonist effects in male Japanese quail

2004 ◽  
Vol 82 (2-3) ◽  
pp. 309-315 ◽  
Author(s):  
C AKINS ◽  
N LEVENS ◽  
R PRATHER ◽  
B COOPER ◽  
T FRITZ
Keyword(s):  
Japanese Quail ◽  
Dopamine Antagonist ◽  
Place Conditioning ◽  
Dose Dependent
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