Viscum album induces Systemic Inflammatory Response Syndrome (SIRS) by intravenous application – conditioning numeric cellular and humoral immune stimulation and clinical efficacy. A prospective observational study in advanced cancer patients

Phytomedicine ◽  
2019 ◽  
Vol 61 ◽  
pp. 9-10
Author(s):  
Juergen J. Kuehn
Keyword(s):  
Systemic Inflammatory Response Syndrome ◽  
Observational Study ◽  
Inflammatory Response ◽  
Cancer Patients ◽  
Advanced Cancer ◽  
Prospective Observational Study ◽  
Viscum Album ◽  
Immune Stimulation ◽  
Advanced Cancer Patients ◽  
Humoral Immune

How long do I have? Observational study on communication about life expectancy with advanced cancer patients

2017 ◽  
Vol 100 (10) ◽  
pp. 1820-1827 ◽  
Author(s):  
I. Henselmans ◽  
E.M.A. Smets ◽  
P.K.J. Han ◽  
H.C.J.C. de Haes ◽  
H.W.M.van Laarhoven
Keyword(s):  
Life Expectancy ◽  
Observational Study ◽  
Cancer Patients ◽  
Advanced Cancer ◽  
Advanced Cancer Patients

scholarly journals Opportunities for antimicrobial stewardship in patients with acute bacterial skin and skin structure infections who are unsuitable for beta-lactam antibiotics: a multicenter prospective observational study

2019 ◽  
Vol 6 ◽  
pp. 204993611882365
Author(s):  
Jonathan A.T. Sandoe ◽  
Kordo Saeed ◽  
Achyut Guleri ◽  
Kieran S. Hand ◽  
Ryan Dillon ◽  
...  
Keyword(s):  
Systemic Inflammatory Response Syndrome ◽  
Observational Study ◽  
Inflammatory Response ◽  
Prospective Observational Study ◽  
Systemic Inflammatory Response ◽  
Skin Structure Infection ◽  
Beta Lactam ◽  
Skin Structure ◽  
Structure Infection ◽  
Beta Lactam Antibiotics

Purpose: The objective of this prospective, observational study was to describe the treatment, severity assessment and healthcare resources required for management of patients with acute bacterial skin and skin structure infections who were unsuitable for beta-lactam antibiotic treatments. Methods: Patients were enrolled across five secondary care National Health Service hospitals. Eligible patients had a diagnosis of acute bacterial skin and skin structure infection and were considered unsuitable for beta-lactam antibiotics (e.g. confirmed/suspected methicillin-resistant Staphylococcus aureus, beta-lactam allergy). Data regarding diagnosis, severity of the infection, antibiotic treatment and patient management were collected. Results: 145 patients with acute bacterial skin and skin structure infection were included; 79% ( n = 115) patients received greater than two antibiotic regimens; median length of the first antibiotic regimen was 2 days (interquartile range of 1–5); median time to switch from intravenous to oral antibiotics was 4 days (interquartile range of 3–8, n = 72/107); 25% ( n = 10/40) patients with Eron class 1 infection had systemic inflammatory response syndrome, suggesting they were misclassified. A higher proportion of patients with systemic inflammatory response syndrome received treatment in an inpatient setting, and their length of stay was prolonged in comparison with patients without systemic inflammatory response syndrome. Conclusion: There exists an urgent need for more focused antimicrobial stewardship strategies and tools for standardised clinical assessment of acute bacterial skin and skin structure infection severity in patients who are unsuitable for beta-lactam antibiotics. This will lead to optimised antimicrobial treatment strategies and ensure effective healthcare resource utilisation.

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