scholarly journals Impact of interleukin-10, soluble CD25 and interferon-γ on the prognosis and early diagnosis of bacteremic systemic inflammatory response syndrome: a prospective observational study

Critical Care ◽  
2013 ◽  
Vol 17 (2) ◽  
pp. R64 ◽  
Author(s):  
Giovanni Matera ◽  
Rossana Puccio ◽  
Aida Giancotti ◽  
Angela Quirino ◽  
Maria Pulicari ◽  
...  
Keyword(s):  
Systemic Inflammatory Response Syndrome ◽  
Early Diagnosis ◽  
Observational Study ◽  
Inflammatory Response ◽  
Prospective Observational Study ◽  
Interleukin 10 ◽  
Interferon Γ ◽  
Systemic Inflammatory Response ◽  
Soluble Cd25

scholarly journals Opportunities for antimicrobial stewardship in patients with acute bacterial skin and skin structure infections who are unsuitable for beta-lactam antibiotics: a multicenter prospective observational study

2019 ◽  
Vol 6 ◽  
pp. 204993611882365
Author(s):  
Jonathan A.T. Sandoe ◽  
Kordo Saeed ◽  
Achyut Guleri ◽  
Kieran S. Hand ◽  
Ryan Dillon ◽  
...  
Keyword(s):  
Systemic Inflammatory Response Syndrome ◽  
Observational Study ◽  
Inflammatory Response ◽  
Prospective Observational Study ◽  
Systemic Inflammatory Response ◽  
Skin Structure Infection ◽  
Beta Lactam ◽  
Skin Structure ◽  
Structure Infection ◽  
Beta Lactam Antibiotics

Purpose: The objective of this prospective, observational study was to describe the treatment, severity assessment and healthcare resources required for management of patients with acute bacterial skin and skin structure infections who were unsuitable for beta-lactam antibiotic treatments. Methods: Patients were enrolled across five secondary care National Health Service hospitals. Eligible patients had a diagnosis of acute bacterial skin and skin structure infection and were considered unsuitable for beta-lactam antibiotics (e.g. confirmed/suspected methicillin-resistant Staphylococcus aureus, beta-lactam allergy). Data regarding diagnosis, severity of the infection, antibiotic treatment and patient management were collected. Results: 145 patients with acute bacterial skin and skin structure infection were included; 79% ( n = 115) patients received greater than two antibiotic regimens; median length of the first antibiotic regimen was 2 days (interquartile range of 1–5); median time to switch from intravenous to oral antibiotics was 4 days (interquartile range of 3–8, n = 72/107); 25% ( n = 10/40) patients with Eron class 1 infection had systemic inflammatory response syndrome, suggesting they were misclassified. A higher proportion of patients with systemic inflammatory response syndrome received treatment in an inpatient setting, and their length of stay was prolonged in comparison with patients without systemic inflammatory response syndrome. Conclusion: There exists an urgent need for more focused antimicrobial stewardship strategies and tools for standardised clinical assessment of acute bacterial skin and skin structure infection severity in patients who are unsuitable for beta-lactam antibiotics. This will lead to optimised antimicrobial treatment strategies and ensure effective healthcare resource utilisation.

Change in the ratio of interleukin-6 to interleukin-10 predicts a poor outcome in patients with systemic inflammatory response syndrome

1999 ◽  
Vol 27 (7) ◽  
pp. 1262-1264 ◽  
Author(s):  
Takumi Taniguchi ◽  
Yuichi Koido ◽  
Jyunichi Aiboshi ◽  
Teruyo Yamashita ◽  
Shinichiro Suzaki ◽  
...  
Keyword(s):  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Interleukin 6 ◽  
Interleukin 10 ◽  
Systemic Inflammatory Response ◽  
Poor Outcome

scholarly journals Anti-inflammatory response of IL-4, IL-10 and TGF-β in patients with systemic inflammatory response syndrome

2000 ◽  
Vol 9 (3-4) ◽  
pp. 193-195 ◽  
Author(s):  
Donato Torre ◽  
Roberto Tambini ◽  
Silvana Aristodemo ◽  
Giovanna Gavazzeni ◽  
Antonio Goglio ◽  
...  
Keyword(s):  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Serum Levels ◽  
Interleukin 10 ◽  
Systemic Inflammatory Response ◽  
Interleukin 4 ◽  
Significant Difference ◽  
Anti Inflammatory

The systemic inflammatory response syndrome (SIRS) is an inflammatory process seen in association with a large number of clinical infective and noninfective conditions.The aim of this study was to investigate the role of anti-inflammatory cytokines such as interleukin–4 (IL–4), interleukin–10 (IL–10), and transforming growth factor-beta (TGF-beta). Serum levels of IL–4, IL–10 and TGF-β were determined in 45 patients with SIRS: 38 patients had SIRS of infectious origin, whereas seven patients had non-infectious SIRS. Twenty healthy subjects were used as controls.Serum levels of IL–4, IL–10 and TGFg were determined by an immunoenzyme assay. A significant increase of IL–4 was observed in these patients at the time of diagnosis and 5 days later. In contrast, serum levels of IL–10 were not increased at the time of diagnosis, but a slight decrease was noted after 5 days. Serum levels of TGF-β were not increased at time of diagnosis, and a slight increase was observed after 5 days. Serum levels of IL–4 were significantly higher in patients with infectious SIRS at the time of diagnosis, whereas no significant difference between infectious and non-infectious SIRS was noted for serum levels of IL–10 and TGF-β at the time of diagnosis and 5 days later.During SIRS, serum levels of IL–4 were significantly increased with a significant correlation between IL–4 and mortality, and only levels of IL–4 were significantly increased in the SIRS caused by infectious stimuli.

Systemic inflammatory response syndrome in the course of status epilepticus: 7-year, two-center observational study

2017 ◽  
Vol 137 ◽  
pp. 53-55 ◽  
Author(s):  
Sebastian Szklener ◽  
Agnieszka Korchut ◽  
Magdalena Godek ◽  
Luiza Balicka-Adamik ◽  
Dariusz Bielecki ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Systemic Inflammatory Response Syndrome ◽  
Observational Study ◽  
Inflammatory Response ◽  
Systemic Inflammatory Response

scholarly journals Comparison of serum biomarkers for the early diagnosis of patients with liver cirrhosis and systemic inflammatory response syndrome

2019 ◽  
Author(s):  
Danhong Yang ◽  
Yuanjun Xie ◽  
Qiang Zhang ◽  
Yicheng Huang ◽  
Yining Dai ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Systemic Inflammatory Response Syndrome ◽  
Early Diagnosis ◽  
Inflammatory Response ◽  
Diagnostic Value ◽  
Serum Biomarkers ◽  
Systemic Inflammatory Response ◽  
Neutrophil Percentage ◽  
Tnf Α ◽  
Wbc Count

Abstract Background Systemic inflammatory response syndrome (SIRS) can cause serious negative effects among patients with liver cirrhosis (LC). . It is very important to finding methods for early diagnose and intervene early in these patients.This study was to assess the accuracy of early diagnostic value of serum biomarkers in patients with LC and SIRS. Methods A total of 123 LC patients were enrolled, 64 of whom were diagnosed with SIRS and 59 patients without SIRS. Various biomarkers and cytokines were measured in two groups of patients: LC+SIRS and LC−SIRS. Receiver operating characteristic curves (ROCs) were used to assess the ability of tested biomarkers to diagnoseLC with SIRS. Results White blood cell (WBC) count, neutrophil percentage(N%), as well as levels of C-reactive protein (CRP), procalcitonin(PCT), soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), interleukin (IL)-6, IL-10 and tumor necrosis factor (TNF)-α, were significantly higher in the LC+SIRS group than in the LC−SIRS group. But only sTREM-1 had high accuracy of the early diagnosis for LC+SIRS. The WBC count, N% as well as levels of CRP, PCT, IL-6, andTNF-α had moderate diagnostic value, and IL-10 had low diagnostic value.The cutoff value of sTREM-1was 179.23 pg/mL and showed 84.4% sensitivity and 93.2% specificity.The AUC of sTREM-1 was 0.904(95%CI 0.899–0.982) and higher than that of the WBC count as well as levels of CRP, PCT, IL-6, IL-10 and TNF-α. In addition, 24 (37.50%) LC+SIRS cases died during 90-day follow-up. Neutrophil percentage as well as levels of CRP, PCT, sTREM-1, IL-6 and TNF-α were significantly higher those who died than in those who survived. Conclusion The WBC count,N% and levels of CRP, PCT, sTREM-1, IL-6, IL-10 and TNF-α are helpful for the early diagnosis of LC+SIRS.Serum sTREM-1 cut-off levels provide better accuracy than customary levels for cirrhosis with SIRS and appears to be a useful early marker to discriminate between SIRS and no-SIRS.It may also be helpful for implications in the prevention and treatment of cirrhosis and SIRS/sepsis.

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