Anti-inflammatory activity of fisetin in human mast cells (HMC-1)

2007 ◽  
Vol 55 (1) ◽  
pp. 31-37 ◽  
Author(s):  
Hyo-Hyun Park ◽  
Soyoung Lee ◽  
Jae-Min Oh ◽  
Myeung-Su Lee ◽  
Kwon-Ha Yoon ◽  
...  
Keyword(s):  
Mast Cells ◽  
Inflammatory Activity ◽  
Human Mast Cells ◽  
Anti Inflammatory

scholarly journals Anti-inflammatory effect of Sinhyowoldo-san Extract with regard to Pro-inflammatory Mediators in PMA plus A23187-induced Human Mast Cells

2014 ◽  
Vol 29 (6) ◽  
pp. 117-123
Author(s):  
Gyeong Wi ◽  
Da-Wun Yang ◽  
Ok-Hwa Kang ◽  
Sung-Bae Kim ◽  
Su-Hyun Mun ◽  
...  
Keyword(s):  
Mast Cells ◽  
Inflammatory Mediators ◽  
Human Mast Cells ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Mast Cells May Regulate The Anti-Inflammatory Activity of IL-37

2019 ◽  
Vol 20 (15) ◽  
pp. 3701 ◽  
Author(s):  
Theoharis C. Theoharides ◽  
Irene Tsilioni ◽  
Pio Conti
Keyword(s):  
Mast Cells ◽  
Immune Cells ◽  
Therapeutic Agents ◽  
Biologically Active ◽  
Inflammatory Activity ◽  
Allergic Reactions ◽  
Regulatory Cytokine ◽  
Inflammatory Processes ◽  
Anti Inflammatory ◽  
Novel Therapeutic

Mast cells are unique immune cells involved in allergic reactions, but also in immunity and inflammation. Interleukin 37 (IL-37) has emerged as an important regulatory cytokine with ability to inhibit immune and inflammatory processes. IL-37 is made primarily by macrophages upon activation of toll-like receptors (TLR) leading to generation of mature IL-37 via the action of caspase 1. In this review, we advance the premise that mast cells could regulate the anti-inflammatory activity of the IL-37 via their secretion of heparin and tryptase. Extracellular IL-37 could either dimerize in the presence of heparin and lose biological activity, or be acted upon by proteases that can generate even more biologically active IL-37 forms. Molecules that could selectively inhibit the secretion of mast cell mediators may, therefore, be used together with IL-37 as novel therapeutic agents.

scholarly journals Chemical Constituents of the Root of Angelica tenuissima and their Anti-allergic Inflammatory Activity

2017 ◽  
Vol 12 (5) ◽  
pp. 1934578X1701200 ◽  
Author(s):  
Hyun Gyu Choi ◽  
In-Gyu Je ◽  
Geum Jin Kim ◽  
Joo-Won Nam ◽  
Sang Hee Shim ◽  
...  
Keyword(s):  
Mast Cells ◽  
Histamine Release ◽  
Methanolic Extract ◽  
Chemical Constituents ◽  
Inflammatory Activity ◽  
Plant Source ◽  
Chemical Structures ◽  
Human Mast Cells ◽  
Reported Data ◽  
First Time

A phthalide, levistolide A (1), and six coumarins, demethylsuberosin (2), fraxetin (3), (-)-marmesinin (4), 3'( S)- O-β-D-glucopyranosyl-3’,4'-dihydroxanthyletin (5), 3'( R)- O-β-D-glucopyranosyl-3’,4'-dihydroxanthyletin (6), and isopraeroside IV (7) were isolated from the methanolic extract of the roots of Angelica tenuissima Nakai. Their chemical structures were confirmed by comparing spectroscopic and reported data. All seven compounds were isolated for the first time from this plant source. The anti-allergic activities of compounds 1-7 were examined using human mast cells, and compounds 1-3 at 10 μM potently suppressed IL-6 expression and inhibited histamine release from human mast cells by more than 30%.

scholarly journals Anti-inflammatory Effect of Columbianetin on Activated Human Mast Cells

2009 ◽  
Vol 32 (6) ◽  
pp. 1027-1031 ◽  
Author(s):  
Hyun-Ja Jeong ◽  
Ho-Jeong Na ◽  
Su-Jin Kim ◽  
Hong-Kun Rim ◽  
Noh-Yil Myung ◽  
...  
Keyword(s):  
Mast Cells ◽  
Human Mast Cells ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Anti-inflammatory effect of Seungmagalgeun-tang extract in human mast cells

2013 ◽  
Vol 28 (5) ◽  
pp. 7-11
Author(s):  
Joon-Ho Keum ◽  
Yun-Soo Seo ◽  
Ok-Hwa Kang ◽  
Jang-Gi Choi ◽  
Dong-Yeul Kwon
Keyword(s):  
Mast Cells ◽  
Human Mast Cells ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT), an anticancer agent, exerts an anti-inflammatory effect in activated human mast cells

2017 ◽  
Vol 66 (10) ◽  
pp. 871-879 ◽  
Author(s):  
Sun-Young Nam ◽  
Na-Ra Han ◽  
Kyoung Wan Yoon ◽  
Hyung-Min Kim ◽  
Hyun-Ja Jeong
Keyword(s):  
Mast Cells ◽  
Anticancer Agent ◽  
Human Mast Cells ◽  
Anti Inflammatory ◽  
Inflammatory Effect
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