Characteristics, complications and management of a large multiethnic cohort of younger adults with type 2 diabetes

2011 ◽  
Vol 5 (4) ◽  
pp. 245-250 ◽  
Author(s):  
Katrien Benhalima ◽  
Soon H. Song ◽  
Emma G. Wilmot ◽  
Kamlesh Khunti ◽  
Laura J. Gray ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Younger Adults ◽  
Multiethnic Cohort

scholarly journals Genome-wide Association Study of Pancreatic Fat: The Multiethnic Cohort Adiposity Phenotype Study

2021 ◽  
Author(s):  
Samantha Streicher ◽  
Unhee Lim ◽  
S. Lani Park ◽  
Yuqing Li ◽  
Xin Sheng ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
European Ancestry ◽  
American Population ◽  
Pancreatic Fat ◽  
Genome Wide ◽  
Multiethnic Cohort

Several studies have found associations between higher pancreatic fat content and adverse health outcomes, such as diabetes and the metabolic syndrome, but investigations into the genetic contributions to pancreatic fat are limited.  This genome-wide association study, comprised of 804 participants with MRI-assessed pancreatic fat measurements, was conducted in the ethnically diverse Multiethnic Cohort-Adiposity Phenotype Study (MEC-APS).  Two genetic variants reaching genome-wide significance, rs73449607 on chromosome 13q21.2 (Beta = -0.67, P = 4.50x10 -8 ) and rs7996760 on chromosome 6q14 (Beta = -0.90, P = 4.91x10 -8 ) were associated with percent pancreatic fat on the log scale.  Rs73449607 was most common in the African American population (13%) and rs79967607 was most common in the European American population (6%).  Rs73449607 was also suggestively associated with lower risk of type 2 diabetes (OR = 0.95, 95% CI = 0.89-1.00, P = 0.047) in the Population Architecture Genomics and Epidemiology (PAGE) Study and the DIAbetes Genetics Replication and Meta-analysis (DIAGRAM), which included substantial numbers of non-European ancestry participants (53,102 cases and 193,679 controls).  Rs73449607 is located in an intergenic region between GSX1 and PLUT , and rs79967607 is in intron 1 of EPM2A .  PLUT, a linkRNA, regulates transcription of an adjacent gene, PDX1 , that controls beta-cell function in the mature pancreas, and EPM2A encodes the protein laforin, which plays a critical role in regulating glycogen production.  If validated, these variants may suggest a genetic component for pancreatic fat and a common etiologic link between pancreatic fat and type 2 diabetes.

Type 2 diabetes in younger adults: Clinical characteristics, diabetes-related complications and management of risk factors

2011 ◽  
Vol 5 (1) ◽  
pp. 57-62 ◽  
Author(s):  
Katrien Benhalima ◽  
Emma Wilmot ◽  
Kamlesh Khunti ◽  
Laura J. Gray ◽  
Ian Lawrence ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Clinical Characteristics ◽  
Younger Adults ◽  
Management Of Risk

scholarly journals No Association of Type 2 Diabetes Risk Variants and Prostate Cancer Risk: the Multiethnic Cohort and PAGE: Table 1.

2011 ◽  
Vol 20 (9) ◽  
pp. 1979-1981 ◽  
Author(s):  
Kevin M. Waters ◽  
Lynne R. Wilkens ◽  
Kristine R. Monroe ◽  
Daniel O. Stram ◽  
Laurence N. Kolonel ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Type 2 Diabetes ◽  
Cancer Risk ◽  
Prostate Cancer Risk ◽  
Diabetes Risk ◽  
Risk Variants ◽  
Multiethnic Cohort ◽  
Page Table

scholarly journals A priori-defined diet quality indices, biomarkers and risk for type 2 diabetes in five ethnic groups: the Multiethnic Cohort

2017 ◽  
Vol 118 (4) ◽  
pp. 312-320 ◽  
Author(s):  
Simone Jacobs ◽  
Carol J. Boushey ◽  
Adrian A. Franke ◽  
Yurii B. Shvetsov ◽  
Kristine R. Monroe ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Ethnic Groups ◽  
Diet Quality ◽  
Healthy Eating Index ◽  
Japanese American ◽  
Dash Score ◽  
Model Assessment ◽  
Quality Indices ◽  
Multiethnic Cohort

AbstractDietary indices have been related to risk for type 2 diabetes (T2D) predominantly in white populations. The present study evaluated this association in the ethnically diverse Multiethnic Cohort and examined four diet quality indices in relation to T2D risk, homoeostatic model assessment-estimated insulin resistance (HOMA-IR) and biomarkers of dyslipidaemia, inflammation and adipokines. The T2D analysis included 166 550 white, African American, Native Hawaiian, Japanese American and Latino participants (9200 incident T2D cases). Dietary intake was assessed at baseline using a quantitative FFQ and T2D status was based on three self-reports and confirmed by administrative data. Biomarkers were assessed about 10 years later in a biomarker subcohort (n 10 060). Sex- and ethnicity-specific hazard ratios were calculated for the Healthy Eating Index-2010 (HEI-2010), the alternative HEI-2010 (AHEI-2010), the alternate Mediterranean diet score (aMED) and the Dietary Approaches to Stop Hypertension (DASH). Multivariable-adjusted means of biomarkers were compared across dietary index tertiles in the biomarker subcohort. The AHEI-2010, aMED (in men only) and DASH scores were related to a 10–20 % lower T2D risk, with the strongest associations in whites and the direction of the relationships mostly consistent across ethnic groups. Higher scores on the four indices were related to lower HOMA-IR, TAG and C-reactive protein concentrations, not related to leptin, and the DASH score was directly associated with adiponectin. The AHEI-2010 and DASH were directly related to HDL-cholesterol in women. Potential underlying biological mechanisms linking diet quality and T2D risk are an improved lipid profile and reduced systemic inflammation and, with regards to DASH alone, an improved adiponectin profile.

scholarly journals Type 2 diabetes risk variants and colorectal cancer risk: the Multiethnic Cohort and PAGE studies

Gut ◽  
2011 ◽  
Vol 60 (12) ◽  
pp. 1703-1711 ◽  
Author(s):  
I. Cheng ◽  
C. P. Caberto ◽  
A. Lum-Jones ◽  
A. Seifried ◽  
L. R. Wilkens ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Type 2 Diabetes ◽  
Cancer Risk ◽  
Diabetes Risk ◽  
Colorectal Cancer Risk ◽  
Risk Variants ◽  
Multiethnic Cohort
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