Type 2 diabetes in younger adults: Clinical characteristics, diabetes-related complications and management of risk factors

2011 ◽  
Vol 5 (1) ◽  
pp. 57-62 ◽  
Author(s):  
Katrien Benhalima ◽  
Emma Wilmot ◽  
Kamlesh Khunti ◽  
Laura J. Gray ◽  
Ian Lawrence ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Clinical Characteristics ◽  
Younger Adults ◽  
Management Of Risk

Serum CA 19–9 Level is Correlated to the Clinical Characteristics and Chronic Complications of Patients Newly Diagnosed with Type 2 Diabetes Mellitus

2019 ◽  
Author(s):  
Limei Cui ◽  
Naqiang Lv ◽  
Bin Li ◽  
Jing Tao ◽  
Xiaomin Zheng ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Regression Analysis ◽  
Clinical Characteristics ◽  
Elevated Serum ◽  
Newly Diagnosed ◽  
Chronic Complications

Abstract Aim This study investigated the relation of serum carbohydrate antigen 199 (CA 19–9) levels to the clinical characteristics and chronic complications of patients newly diagnosed with type 2 diabetes mellitus (T2DM). Methods A total of 371 patients newly diagnosed with T2DM and 133 healthy people with consecutively matched age were compared. The 371 patients with T2DM were divided into four groups by quartiles based on their serum CA 19–9 levels, in which clinical characteristics and chronic complications, such as diabetic retinopathy (DR), diabetic nephropathy, and macrovascular complications were compared. Logistic regression analysis was used to evaluate the risk factors of DR. Results Among the 371 patients newly diagnosed with T2DM, 60 had elevated CA 19–9 levels (16.17%). The frequencies of elevated serum CA 19–9 were 24.39% (30 of 123) for females and 12.10% (30 of 248) for males, in which the values for females were higher than those for males (P<0.01).Differences were observed among the serum CA 19–9 levels, hemoglobin A1c (HbA1c), and DR (P<0.05). Logistic regression analysis showed that serum CA 19–9 levels, fasting blood glucose (FBG) and fasting C-peptide (FC-P) were risk factors for DR (P<0.05). Conclusions Serum CA 19–9 levels were correlated with HbA1c and DR in patients newly diagnosed with T2DM. The elevated serum CA 19–9 levels, high FC-P, and FBG levels were important risk factors for DR in patients newly diagnosed with T2DM.

Prevalence, clinical characteristics, and risk factors of sarcopenia in overweight patients with type 2 diabetes

2016 ◽  
Vol 120 ◽  
pp. S190-S191
Author(s):  
Kentaro Yamada ◽  
Hitomi Nakayama ◽  
Munehisa Tsuruta ◽  
Satomi Kakino ◽  
Seiko Kawano ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Clinical Characteristics

scholarly journals Clinical Characteristics and Prognostic Analysis of Patients With Pulmonary Tuberculosis and Type 2 Diabetes Comorbidity in China: A Retrospective Analysis

2021 ◽  
Vol 9 ◽  
Author(s):  
Shijie Zhang ◽  
Xiang Tong ◽  
Lei Wang ◽  
Tianli Zhang ◽  
Jizhen Huang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Clinical Characteristics ◽  
Albumin Level ◽  
Older Age ◽  
Hypoglycemic Agents ◽  
Cox Regression Analysis ◽  
Pulmonary Tb ◽  
Independent Risk Factors

Background: Tuberculosis (TB) is one of the leading communicable diseases, with significant morbidity and mortality. Diabetes can increase the risk of developing TB and the related adverse outcomes. This study retrospectively analyzed the clinical characteristics and prognosis of patients with pulmonary TB and type 2 diabetes comorbidity.Methods: About 282 cases with pulmonary TB and type 2 diabetes comorbidity were identified from West China Hospital between January 1, 2010, and December 31, 2016, and were followed up for at least 3 years. We further used Kaplan–Meier methods and COX regression analysis to identify the influence factors for all-cause death.Results: Compared to the survival patients, patients who died were older, exhibited significantly lower albumin and hemoglobin levels, but higher Charlson Comorbidity Index (CCI) score at admission, and had a lower usage rate of metformin. The all-cause mortality rates at 1 and 5 years were 5.67 and 20.59%, separately. For 1-year all-cause death, higher albumin level (HR = 0.90, 95% CI: 0.81–0.99) was the independently protective factor, but older age (HR = 1.07, 95% CI: 1.01–1.13) and CCI score ≥3 (HR = 6.77, 95% CI: 1.40–32.69) were the independent risk factors. For long-term all-cause death, higher albumin level (HR = 0.94, 95% CI: 0.88–1.00), the use of metformin (HR = 0.21, 95% CI: 0.07–0.59), insulin (HR = 0.27, 95% CI: 0.10–0.74), or sulfonylureas (HR = 0.23, 95% CI: 0.07–0.74) were the independently protective factors, but older age (HR = 1.03, 95% CI: 1.00–1.07) and CCI score ≥3 (HR = 7.15, 95% CI: 2.56–19.92) were the independent risk factors.Conclusions: The lower albumin level, older age, and CCI score ≥3 were predictors of all-cause death in patients with pulmonary TB and type 2 diabetes comorbidity. In the long run, patients who use metformin, insulin, or sulfonylureas as hypoglycemic agents may have a lower incidence of death.

Clinical characteristics and risk factors for retinal diabetic neurodegeneration in type 2 diabetes

2017 ◽  
Vol 54 (11) ◽  
pp. 993-999 ◽  
Author(s):  
Kiyoung Kim ◽  
Eung Suk Kim ◽  
Sang Youl Rhee ◽  
Suk Chon ◽  
Jeong-taek Woo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Clinical Characteristics

scholarly journals THU0426 CLINICAL CHARACTERISTIC OF INFECTIOUS ULCERATION OVER TOPHI

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 451.2-452
Author(s):  
Z. Huang ◽  
T. LI ◽  
X. Liu
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Antibiotic Susceptibility ◽  
Clinical Characteristics ◽  
Albumin Level ◽  
Gram Positive ◽  
Gram Negative ◽  
Antibiotic Susceptibility Patterns ◽  
Susceptibility Patterns

Background:Infection in ulceration over tophi is the leading cause of sepsis in patients with gout, which is the main indication for surgery. Additionally, patients with infection will significantly prolonged wound closure time compared with those without infection. Investigation of infection in ulceration over tophi will improve our understanding of this critical issue.Objectives:To describe the microbiological profile in ulceration over tophi, antibiotic susceptibility patterns of causative agents, and to study the prediction of infection in ulceration over tophi among patients with gout.Methods:Patients with ulceration over tophi were prospectively enrolled. The clinical characteristics were recorded and microbiological specimens were taken on admission. Specimens were cultured for aerobic and anaerobic bacteria, and antibiotic susceptibility testing was performed for the culture isolates. Patients were divided into 2 groups according to having infectious ulceration or not and the potential risk factors for infectious ulceration over tophi were examined using univariate and multivariate logistic regression analyses.Results:A total of 82 patients were included for analysis. 46 pathogens were isolated from 39 (47.6%) patients, among which the top 3 wereStaphylococcus aureus(43.5%),Pseudomonas aeruginosa(17.4%) andEnterococcus faecalis(13.0%). Overall, the Gram-positive bacilli were more sensitive to gentamicin (81.5%), amikacin (88.9%), trimethoprim/sulfamethoxazole (92.6%), nitrofurantoin (96.3%), linezolid (100.0%), teicoplanin (100.0%) and vancomycin (100.0%) whereas penicillin, oxacillin and ampicillin were 66.7% to 77.8% resistant. The Gram-negative bacilli were more sensitive to amikacin (84.2%), cefoperazone/sulbactam (84.2%) and meropenem (89.5%) whereas ampicillin, amoxicillin/clavulanate, cefotaxime, cefazolin, piperacillin, trimethoprim/sulfamethoxazole and tetracycline were 68.4% to 100% resistant. Patients with infection had a higher rate of smoking history and type 2 diabetes, with higher levels of erythrocyte sedimentation rate, C-reactive protein and leucocyte, and lower level of albumin. In stepwise logistic regression analysis, type 2 diabetes (adjusted OR 5.064; 95% CI = 1.430 to 17.928) and albumin level (adjusted OR 0.855; 95% CI = 0.782 to 0.935) were independent predictors of infection in ulceration over tophi.Conclusion:Infection is common in ulceration over tophi. Different antibiotic susceptibility patterns were observed in Gram-positive bacilli and Gram-negative bacilli. Type 2 diabetes and low albumin level were associated with an increased risk of infection in ulceration over tophi. The data in this study will be beneficial for tailoring infection control measures in a way that improves outcomes of ulceration over tophi.References:[1]Huang Z, Liu X, Liu Y, et al. Clinical characteristics and risk factors of ulceration over tophi in patients with gout.International journal of rheumatic diseases2019;22:1052-7.[2]Xu J, Zhu Z, Zhang W. Clinical characteristics of infectious ulceration over tophi in patients with gout.The Journal of international medical research2018;46:2258-64.Table 1.Bacteria isolated from initial ulceration specimens taken on the first admission.BacteriaNumber* (n = 46)Proportion (%)Gram-positive bacilli2758.7 Staphylococcus aureus2043.5 Enterococcus faecalis613.0 Streptococcus mutans12.2Gram-negative bacilli1941.3 Pseudomonas aeruginosa817.4 Klebsiella pneumonia48.7 Enterobacter cloacae36.5 Escherichia coli24.3 Acinetobacter baumannii24.3* Number of ulcerationDisclosure of Interests: :None declared

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