Reinstatement of cocaine self-administration in rats: sex differences

2000 ◽  
Vol 148 (2) ◽  
pp. 196-200 ◽  
Author(s):  
Wendy J. Lynch ◽  
Marilyn E. Carroll
Keyword(s):  
Sex Differences ◽  
Self Administration

scholarly journals Sex Differences in Escalated Methamphetamine Self-Administration and Altered Gene Expression Associated With Incubation of Methamphetamine Seeking

2019 ◽  
Vol 22 (11) ◽  
pp. 710-723 ◽  
Author(s):  
Atul P Daiwile ◽  
Subramaniam Jayanthi ◽  
Bruce Ladenheim ◽  
Michael T McCoy ◽  
Christie Brannock ◽  
...  
Keyword(s):  
Sex Differences ◽  
Nucleus Accumbens ◽  
Fixed Ratio ◽  
Female Rats ◽  
Male Rats ◽  
Mrna Levels ◽  
Self Administration ◽  
Male And Female ◽  
Orexin Receptors ◽  
Male And Female Rats

Abstract Background Methamphetamine (METH) use disorder is prevalent worldwide. There are reports of sex differences in quantities of drug used and relapses to drug use among individuals with METH use disorder. However, the molecular neurobiology of these potential sex differences remains unknown. Methods We trained rats to self-administer METH (0. 1 mg/kg/infusion, i.v.) on an fixed-ratio-1 schedule for 20 days using two 3-hour daily METH sessions separated by 30-minute breaks. At the end of self-administration training, rats underwent tests of cue-induced METH seeking on withdrawal days 3 and 30. Twenty-four hours later, nucleus accumbens was dissected and then used to measure neuropeptide mRNA levels. Results Behavioral results show that male rats increased the number of METH infusions earlier during self-administration training and took more METH than females. Both male and female rats could be further divided into 2 phenotypes labeled high and low takers based on the degree of escalation that they exhibited during the course of the METH self-administration experiment. Both males and females exhibited incubation of METH seeking after 30 days of forced withdrawal. Females had higher basal mRNA levels of dynorphin and hypocretin/orexin receptors than males, whereas males expressed higher vasopressin mRNA levels than females under saline and METH conditions. Unexpectedly, only males showed increased expression of nucleus accumbens dynorphin after METH self-administration. Moreover, there were significant correlations between nucleus accumbens Hcrtr1, Hcrtr2, Crhr2, and Avpr1b mRNA levels and cue-induced METH seeking only in female rats. Conclusion Our results identify some behavioral and molecular differences between male and female rats that had self-administered METH. Sexual dimorphism in responses to METH exposure should be considered when developing potential therapeutic agents against METH use disorder.

Sex differences in the escalation of oral phencyclidine (PCP) self-administration under FR and PR schedules in rhesus monkeys

2005 ◽  
Vol 180 (3) ◽  
pp. 414-426 ◽  
Author(s):  
Marilyn E. Carroll ◽  
David K. Batulis ◽  
Kerry L. Landry ◽  
Andrew D. Morgan
Keyword(s):  
Sex Differences ◽  
Rhesus Monkeys ◽  
Self Administration

Intravenous cocaine and heroin self-administration in rats selectively bred for differential saccharin intake: phenotype and sex differences

2002 ◽  
Vol 161 (3) ◽  
pp. 304-313 ◽  
Author(s):  
Marilyn Carroll ◽  
Andrew Morgan ◽  
Wendy Lynch ◽  
Una Campbell ◽  
Nancy Dess
Keyword(s):  
Sex Differences ◽  
Self Administration ◽  
Saccharin Intake ◽  
Intravenous Cocaine

scholarly journals Sex differences in the effect of the FKBP5 inhibitor SAFit2 on anxiety and stress-induced reinstatement following cocaine self-administration

2020 ◽  
Vol 13 ◽  
pp. 100232
Author(s):  
Krista L. Connelly ◽  
Cassandra C. Wolsh ◽  
Jeffrey L. Barr ◽  
Michael Bauder ◽  
Felix Hausch ◽  
...  
Keyword(s):  
Sex Differences ◽  
Self Administration

scholarly journals Human sex differences in d-amphetamine self-administration

Addiction ◽  
2010 ◽  
Vol 105 (4) ◽  
pp. 727-731 ◽  
Author(s):  
Andrea R. Vansickel ◽  
William W. Stoops ◽  
Craig R. Rush
Keyword(s):  
Sex Differences ◽  
Human Sex Differences ◽  
Self Administration

scholarly journals Estradiol as a Mechanism for Sex Differences in the Development of an Addicted Phenotype following Extended Access Cocaine Self-Administration

2013 ◽  
Vol 38 (9) ◽  
pp. 1698-1705 ◽  
Author(s):  
Carolina P Ramôa ◽  
Susan E Doyle ◽  
Diana W Naim ◽  
Wendy J Lynch
Keyword(s):  
Sex Differences ◽  
Self Administration ◽  
Extended Access

scholarly journals Sex differences in the effect of wheel running on subsequent nicotine-seeking in a rat adolescent-onset self-administration model

2013 ◽  
Vol 231 (8) ◽  
pp. 1753-1762 ◽  
Author(s):  
Victoria Sanchez ◽  
Catherine F. Moore ◽  
Darlene H. Brunzell ◽  
Wendy J. Lynch
Keyword(s):  
Sex Differences ◽  
Wheel Running ◽  
Self Administration

scholarly journals Oral prescription opioid-seeking behavior in male and female mice

2019 ◽  
Author(s):  
Alysabeth G. Phillips ◽  
Dillon J. McGovern ◽  
Soo Lee ◽  
Kyu Ro ◽  
David T. Huynh ◽  
...  
Keyword(s):  
Sex Differences ◽  
Oral Drug ◽  
Prescription Opioid ◽  
Male Mice ◽  
Self Administration ◽  
Female Mice ◽  
Seeking Behavior ◽  
Opioid Users ◽  
Psychomotor Stimulation

AbstractA significant portion of prescription opioid users self-administer orally rather than intravenously. Animal models of opioid addiction have demonstrated that intravenous cues are sufficient to cause drug-seeking. However, intravenous models may not model oral users, and the preference to self-administer orally appears to be partially influenced by the user’s sex. Our objectives were to determine whether oral opioid-associated cues are sufficient for relapse and whether sex differences exist in relapse susceptibility. Mice orally self-administered escalating doses of oxycodone under postprandial (prefed) or non-postprandial (no prefeeding) conditions. Both sexes demonstrated robust cue-induced reinstatement. In separate mice we found that oral oxycodone cues were sufficient to reinstate extinguished oral oxycodone-seeking behavior in the absence of postprandial or prior water self-administration training. During self-administration, we found that female mice earned significantly more mg/kg oxycodone than male mice. Follow-up studies indicated sex differences in psychomotor stimulation and plasma oxycodone/oxymorphone following oral oxycodone administration. In addition, gonadal steroid studies were performed in which we found divergent responses where ovariectomy enhanced and orchiectomy suppressed oral self-administration. While the suppressive effects of orchiectomy were identified across doses and postprandial conditions, the enhancing effects of ovariectomy were selective to non-postprandial conditions. These studies establish that 1) oral drug cues are sufficient to cause reinstatement that is independent of prandial conditions and water-seeking behavior, 2) earned oral oxycodone is larger in female mice compared with male mice potentially through differences in psychomotor stimulation and drug metabolism, and 3) gonadectomy produces divergent effects on oral oxycodone self-administration between sexes.

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