Role of GABAA receptor in modulation of acute thermal pain using a rat model of cholestasis

2014 ◽  
Vol 124 ◽  
pp. 226-230 ◽  
Author(s):  
Parisa Hasanein ◽  
Mohsen Parviz
Keyword(s):  
Gabaa Receptor ◽  
Rat Model ◽  
Thermal Pain ◽  
Acute Thermal Pain

scholarly journals Role of intracellular calcium in acute thermal pain perception

2004 ◽  
Vol 47 (6) ◽  
pp. 935-944 ◽  
Author(s):  
Nicoletta Galeotti ◽  
Alessandro Bartolini ◽  
Carla Ghelardini
Keyword(s):  
Intracellular Calcium ◽  
Pain Perception ◽  
Thermal Pain ◽  
Acute Thermal Pain

The role of GABAA receptor biogenesis, structure and function in epilepsy

2006 ◽  
Vol 34 (5) ◽  
pp. 863-867 ◽  
Author(s):  
S. Mizielinska ◽  
S. Greenwood ◽  
C.N. Connolly
Keyword(s):  
Gabaa Receptor ◽  
Structure And Function ◽  
Inhibitory Synapses ◽  
Normal Brain ◽  
Synaptic Targeting ◽  
Acid Type ◽  
Normal Brain Function ◽  
And Function ◽  
The Brain

Maintaining the correct balance in neuronal activation is of paramount importance to normal brain function. Imbalances due to changes in excitation or inhibition can lead to a variety of disorders ranging from the clinically extreme (e.g. epilepsy) to the more subtle (e.g. anxiety). In the brain, the most common inhibitory synapses are regulated by GABAA (γ-aminobutyric acid type A) receptors, a role commensurate with their importance as therapeutic targets. Remarkably, we still know relatively little about GABAA receptor biogenesis. Receptors are constructed as pentameric ion channels, with α and β subunits being the minimal requirement, and the incorporation of a γ subunit being necessary for benzodiazepine modulation and synaptic targeting. Insights have been provided by the discovery of several specific assembly signals within different GABAA receptor subunits. Moreover, a number of recent studies on GABAA receptor mutations associated with epilepsy have further enhanced our understanding of GABAA receptor biogenesis, structure and function.

scholarly journals Diazepam-induced changes in sleep: Role of the  1 GABAA receptor subtype

2001 ◽  
Vol 98 (11) ◽  
pp. 6464-6469 ◽  
Author(s):  
I. Tobler ◽  
C. Kopp ◽  
T. Deboer ◽  
U. Rudolph
Keyword(s):  
Gabaa Receptor ◽  
Receptor Subtype ◽  
Induced Changes
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