scholarly journals Reversal of apomorphine locomotor sensitization by a single post-conditioning trial treatment with a low autoreceptor dose of apomorphine: A memory re-consolidation approach

2011 ◽  
Vol 99 (1) ◽  
pp. 29-34 ◽  
Author(s):  
Marinete Pinheiro Carrera ◽  
Robert J. Carey ◽  
Flávia Regina Cruz Dias ◽  
Liana Wermelinger de Matos
Keyword(s):  
Conditioning Trial ◽  
Locomotor Sensitization ◽  
Trial Treatment

An Evaluation of a Combat Conditioning Trial Program

2008 ◽  
Author(s):  
Jr Vickers ◽  
Reynolds Ross R. ◽  
Jordan John H. ◽  
Hervig Justin R. ◽  
Linda K.
Keyword(s):  
Conditioning Trial

Resistance of neuronal nitric oxide synthase-deficient mice to cocaine-induced locomotor sensitization

1998 ◽  
Vol 140 (3) ◽  
pp. 378-386 ◽  
Author(s):  
Y. Itzhak ◽  
Syed F. Ali ◽  
Julio L. Martin ◽  
M. Dean Black ◽  
Paul L. Huang
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Neuronal Nitric Oxide Synthase ◽  
Locomotor Sensitization ◽  
Oxide Synthase ◽  
Deficient Mice

scholarly journals CTIM-15. PRELIMINARY RESULTS OF A PHASE II STUDY OF NIVOLUMAB WITH HYPOFRACTIONATED RE-RADIATION AND BEVACIZUMAB FOR RECURRENT MGMT METHYLATED GLIOBLASTOMA

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii36-ii36
Author(s):  
Christian Grommes ◽  
Minesh Mehta ◽  
Alexandra Miller ◽  
Mariza Daras ◽  
Anna Piotrowski ◽  
...  
Keyword(s):  
Phase Ii ◽  
Phase Ii Study ◽  
Checkpoint Inhibitors ◽  
Single Agent ◽  
Progression Free Survival ◽  
Standard Of Care ◽  
Disease Recurrence ◽  
Primary Objective ◽  
Significant Finding ◽  
Trial Treatment

Abstract Standard of standard of care for glioblastoma (GBM) remains unsatisfactory with universal disease recurrence and a median survival of < 2 years. Immune checkpoint inhibitors (ICI) have shown limited single-agent activity in GBM thus far. GBMs with methylated MGMT promoter and no baseline corticosteroid dependence may be most likely to derive benefit from ICI. The combination of ICIs with radiation has shown promising activity in other human cancers. Combining nivolumab and re-RT/bevacizumab in GBM may augment ICI activity through immunogenic effects of radiation, may reduce the risk of radiation necrosis by addition of bevacizumab at the time of radiation, and may reduce the need for corticosteroids. In this multicenter phase II study, nivolumab is combined with re-irradiation and optional concurrent bevacizumab followed by nivolumab in patients with first recurrence of IDH-wildtype and MGMT methylated glioblastoma. Primary objective is to improve 1-year overall survival (OS) from 33 (based on EORTC 26101) to 50%. Nine-three patients are required to show a significant finding with an α of 0.05 and 81% power. Thirteen of 93 patient (14%) have been enrolled with a median age of 59 (range 42–71) with a median KPS of 90 (range 70–90). Treatment has been tolerated well without any grade ≥ 4 toxicities and only one grade 3 (amylase elevation). The most common adverse events were pruritus and hypothyroidism in 3/13 (23%). The median progression-free survival (PFS) is 7 months with a 6months PFS of 55.6%. The 12months OS is 66.7%. Patients with recurrent MGMT methylated, IDH-wildtype glioblastoma tolerate trial treatment with acceptable toxicities. Clinical efficacy in the first patients enrolled shows a promising effect. Enrollment is ongoing.

Clozapine inhibits development and expression of nicotine-induced locomotor sensitization in rats

Synapse ◽  
2009 ◽  
Vol 63 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Hakan Kayir ◽  
Gokhan Goktalay ◽  
Murat Yildirim ◽  
Tayfun I. Uzbay
Keyword(s):  
Locomotor Sensitization

Repeated heroin in rats produces locomotor sensitization and enhances appetitive Pavlovian and instrumental learning involving food reward

2009 ◽  
Vol 91 (3) ◽  
pp. 351-357 ◽  
Author(s):  
Robert Ranaldi ◽  
Jonathan Egan ◽  
Karen Kest ◽  
Matthew Fein ◽  
Andrew R. Delamater
Keyword(s):  
Food Reward ◽  
Instrumental Learning ◽  
Locomotor Sensitization

Withania somnifera attenuates nicotine induced locomotor sensitization and withdrawal symptoms in mice

2018 ◽  
Vol 7 (2) ◽  
pp. 180-184
Author(s):  
Nitin G Dumore ◽  
◽  
Milind J Umekar ◽  
Brijrsh G Taksande ◽  
Manish M Aglawe ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
Withania Somnifera ◽  
Anxiolytic Effect ◽  
Treated Group ◽  
Saline Group ◽  
Nicotine Withdrawal ◽  
Withdrawal Symptoms ◽  
Locomotor Sensitization ◽  
Nicotine Treatment ◽  
Per Se

Objective: To investigate the effect of withania somnifera extract (WSE) on nicotine mediated reinforcement effect and withdrawal symptoms which attributed for the addiction liabilities of nicotine. Methods: In Swiss albino mice nicotine mediated locomotor sensitization and anxiogenic effects of chronic and acute nicotine treatment respectively was tested per se or in combination with WSE. In addition, nicotine withdrawal induced anxiety-like behavior was also studied. Locomotor sensitization was tested by employing open field test (OFT), while symptoms of anxiety were evaluated by subjecting mice to elevated plus maze (EPM). Results: Daily treatment with nicotine (subcutaneous) for 7 days showed gradual increase in the locomotor activity in OFT as compared to saline group indicating the development of locomotor sensitization. Following 3 days of drug free period, nicotine challenge on day 11 also showed rise in locomotor activity depicting expression of sensitization. WSE pretreatment inhibited the nicotine induced development and expression of locomotor sensitization. WSE+nicotine treated group showed decreased ambulations as compared to per se nicotine group on day 1-7 and day 8 (P<0.05). In EPM, acute nicotine treated mice spend more time in open arms as compared to saline indicating the anxiolytic behavior. WSE pretreatment reversed this anxiolytic effect. Nicotine withdrawal mice showed significant increase in the number of entries in arm and total time spend in closed arm indicating anxiety-like behavior. WSE treatment in nicotine withdrawal mice inhibited the nicotine withdrawal induced increased number of entries and time spend in closed arms. Conclusion: These results indicated that WSE may serve an effective herbal medicine in arresting nicotine mediated reinforcement and withdrawal signs

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