Effect of MK-801 and ketamine on hydroxyl radical generation in the posterior cingulate and retrosplenial cortex of free-moving mice, as determined by in vivo microdialysis

2007 ◽  
Vol 86 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Dai-Ying Zuo ◽  
Ying-Liang Wu ◽  
Wen-Xue Yao ◽  
Yue Cao ◽  
Chun-Fu Wu ◽  
...  
Keyword(s):  
Hydroxyl Radical ◽  
In Vivo Microdialysis ◽  
Retrosplenial Cortex ◽  
Mk 801 ◽  
Posterior Cingulate ◽  
Radical Generation

MK-801 and ketamine induce heat shock protein HSP72 in injured neurons in posterior cingulate and retrosplenial cortex

1991 ◽  
Vol 30 (6) ◽  
pp. 801-809 ◽  
Author(s):  
Frank R. Sharp ◽  
Pat Jasper ◽  
John Hall ◽  
Linda Noble ◽  
Stephen M. Sagar
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Retrosplenial Cortex ◽  
Mk 801 ◽  
Posterior Cingulate

Propofol and sodium thiopental protect against MK-801-induced neuronal necrosis in the posterior cingulate/retrosplenial cortex

2001 ◽  
Vol 913 (2) ◽  
pp. 185-189 ◽  
Author(s):  
Vesna Jevtovic-Todorovic ◽  
David F Wozniak ◽  
Sarah Powell ◽  
John W Olney
Keyword(s):  
Retrosplenial Cortex ◽  
Neuronal Necrosis ◽  
Sodium Thiopental ◽  
Mk 801 ◽  
Posterior Cingulate

scholarly journals The Impact of the Combined Administration of 1MeTIQ and MK-801 on Cell Viability, Oxidative Stress Markers, and Glutamate Release in the Rat Hippocampus

2021 ◽  
Author(s):  
Agnieszka Wąsik ◽  
Magdalena Białoń ◽  
Danuta Jantas ◽  
Marcelina Żarnowska
Keyword(s):  
Oxidative Stress ◽  
Enzyme Activity ◽  
Antioxidant Enzyme ◽  
Glutamate Release ◽  
Combined Treatment ◽  
In Vivo Microdialysis ◽  
Antioxidant Enzyme Activity ◽  
Rat Hippocampus ◽  
Mk 801

AbstractMK-801, as an N-methyl-D-aspartate (NMDA) receptor inhibitor, causes elevation in glutamate release, which may lead to an increase in excitotoxicity, oxidative stress and, consequently, cell death. 1-Methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ) shows antioxidant activity. The aim of the present study was to evaluate the effect of combined treatment with 1MeTIQ and MK-801 on cell viability, antioxidant enzyme activity, and glutamate release in the rat hippocampus. Cytotoxicity was measured using lactate dehydrogenase leakage assay (LDH) and the methyl tetrazolium (MTT) assay; antioxidant enzyme activity (glutathione peroxidase (GPx), glutathione reductase (GR), superoxide dismutase (SOD), and catalase (CAT)) were measured by ELISA kits. The release of glutamate in the rat hippocampus was measured using in vivo microdialysis methodology. An in vitro study showed that MK-801 induced cell death in a concentration-dependent manner and that 1MeTIQ partially reduced this adverse effect of MK-801. An ex vivo study indicated that MK-801 produced an increase in antioxidant enzyme activity (GPx, GR, and SOD), whereas coadministration of MK-801 and 1MeTIQ restored the activity of these enzymes to the control level. An in vivo microdialysis study demonstrated that combined treatment with both drugs decreased the release of glutamate in the rat hippocampus. The above results revealed that 1MeTIQ shows limited neuroprotective activity under conditions of glutamate-induced neurotoxicity.

MK-801 attenuates the dopamine-releasing but not the behavioral effects of methamphetamine: an in vivo microdialysis study

1991 ◽  
Vol 549 (2) ◽  
pp. 230-235 ◽  
Author(s):  
Fredric B. Weihmuller ◽  
Steven J. O'Dell ◽  
Barry N. Cole ◽  
John F. Marshall
Keyword(s):  
In Vivo Microdialysis ◽  
Behavioral Effects ◽  
Mk 801 ◽  
Microdialysis Study
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