Neuronal vacuole formation in the rat posterior cingulate/retrosplenial cortex after treatment with the N?-methyl-D-aspartate (NMDA) antagonist MK-801 (dizocilpine maleate)

1994 ◽  
Vol 88 (6) ◽  
pp. 511-519
Author(s):  
A. S. Fix ◽  
Jeffrey W. Horn ◽  
Lewis L. Truex ◽  
Ronald A. Smith ◽  
Ernesto Gomez
Keyword(s):  
Nmda Antagonist ◽  
Retrosplenial Cortex ◽  
Mk 801 ◽  
Vacuole Formation ◽  
Posterior Cingulate

scholarly journals Isoflurane and Propofol Block Neurotoxicity Caused by MK-801 in the Rat Posterior Cingulate/Retrosplenial Cortex

1997 ◽  
Vol 17 (2) ◽  
pp. 168-174 ◽  
Author(s):  
Vesna Jevtović-Todorović ◽  
Charity O. Kirby ◽  
John W. Olney
Keyword(s):  
Brain Injury ◽  
Neuronal Degeneration ◽  
Nmda Antagonist ◽  
Retrosplenial Cortex ◽  
Acute Brain Injury ◽  
Nmda Antagonists ◽  
General Anesthetics ◽  
General Anesthetic ◽  
Mk 801 ◽  
Anesthetic Agents

In acute brain injury syndromes, the potent N-methyl-D-aspartate (NMDA) antagonist, MK-801, can prevent neuronal degeneration, and the general anesthetics, isoflurane and propofol, may also provide neuroprotective benefits. An obstacle to the use of NMDA antagonists for neuroprotective purposes is that they can cause a neurotoxic vacuole reaction in cerebrocortical neurons. This study demonstrates the ability of isoflurane and propofol to prevent the neurotoxic vacuole reaction induced by MK-801. Low sedative doses of inhaled isoflurane (1%) or intravenous (i.v.) propofol (7.5 mg/kg/h) were as effective as higher general anesthetic doses. Thus, in the clinical management of acute brain injury conditions such as stroke and brain trauma, administration of one of these anesthetic agents together with an NMDA antagonist may be an excellent formula for obtaining optimal neuroprotection while eliminating serious side effects.

MK-801 and ketamine induce heat shock protein HSP72 in injured neurons in posterior cingulate and retrosplenial cortex

1991 ◽  
Vol 30 (6) ◽  
pp. 801-809 ◽  
Author(s):  
Frank R. Sharp ◽  
Pat Jasper ◽  
John Hall ◽  
Linda Noble ◽  
Stephen M. Sagar
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Retrosplenial Cortex ◽  
Mk 801 ◽  
Posterior Cingulate

Propofol and sodium thiopental protect against MK-801-induced neuronal necrosis in the posterior cingulate/retrosplenial cortex

2001 ◽  
Vol 913 (2) ◽  
pp. 185-189 ◽  
Author(s):  
Vesna Jevtovic-Todorovic ◽  
David F Wozniak ◽  
Sarah Powell ◽  
John W Olney
Keyword(s):  
Retrosplenial Cortex ◽  
Neuronal Necrosis ◽  
Sodium Thiopental ◽  
Mk 801 ◽  
Posterior Cingulate

Quantitative analysis of factors influencing neuronal necrosis induced by MK-801 in the rat posterior cingulate/retrosplenial cortex

1995 ◽  
Vol 696 (1-2) ◽  
pp. 194-204 ◽  
Author(s):  
Andrew S. Fix ◽  
David F. Wozniak ◽  
Lewis L. Truex ◽  
Melanie McEwen ◽  
J. Phillip Miller ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Retrosplenial Cortex ◽  
Neuronal Necrosis ◽  
Mk 801 ◽  
Posterior Cingulate ◽  
Factors Influencing

INTERACTION BETWEEN THE NONCOMPETITIVE NMDA ANTAGONIST MK-801 AND MORPHINE: EVALUATION BY AMBULATORY ACTIVITY IN MICE.

1992 ◽  
Vol 15 ◽  
pp. 635B
Author(s):  
Y. Iijima ◽  
T. Asami ◽  
H. Kuribara ◽  
I. Ida ◽  
T. Higuchi ◽  
...  
Keyword(s):  
Nmda Antagonist ◽  
Ambulatory Activity ◽  
Mk 801
Sign in / Sign up

Export Citation Format

Share Document