Increased sensitization to morphine-induced oral stereotypy in aged rats

2004 ◽  
Vol 79 (3) ◽  
pp. 491-497 ◽  
Author(s):  
Clifford M. Knapp ◽  
Shivkumar H. Jha ◽  
Conan Kornetsky
Keyword(s):  
Aged Rats ◽  
Oral Stereotypy

The role of asymmetric dimethylarginine in myocardial aging of aged rats and its mechanisms

2010 ◽  
Vol 34 (8) ◽  
pp. S29-S29
Author(s):  
Ru Zhang ◽  
Yong Zhen Gong ◽  
Wen Juan Xu ◽  
Yao Pan ◽  
Yan Xiong
Keyword(s):  
Asymmetric Dimethylarginine ◽  
Aged Rats ◽  
Myocardial Aging

Butea Frondosa, A Rho Kinase 2 and Phosphodiesterase 5 Enzyme Inhibitor, Increases Sexual Function In Young And Aged Rats

Planta Medica ◽  
2013 ◽  
Vol 79 (10) ◽  
Author(s):  
S Kumar Goswami ◽  
M Naseeruddin Inamdar ◽  
S Dethe ◽  
A Agarwal
Keyword(s):  
Sexual Function ◽  
Enzyme Inhibitor ◽  
Rho Kinase ◽  
Aged Rats ◽  
Phosphodiesterase 5

On the Fibrinolytic System in Aged Rats, and Its Reactivity to Endotoxin and Cytokines

1992 ◽  
Vol 67 (06) ◽  
pp. 697-701 ◽  
Author(s):  
J J Emeis ◽  
A Brouwer ◽  
R J Barelds ◽  
M A Horan ◽  
S K Durham ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Fibrinolytic Activity ◽  
Fibrinolytic System ◽  
Tissue Type ◽  
High Dose ◽  
Base Line ◽  
Aged Rats ◽  
Tissue Type Plasminogen Activator ◽  
Young Rats ◽  
Type Plasminogen Activator

SummaryAged rats are more susceptible to endotoxin-induced effects, including microthrombosis and platelet aggregation, than are young rats. To investigate whether changes in the fibrinolytic system might be involved, we investigated the fibrinolytic activity in plasma euglobulin fractions and tissues (lung and heart) of young (6-months old) and aged (24-months old) rats under baseline conditions and after challenge with endotoxin. Aged rats had lower plasma levels of tissue-type plasminogen activator (t-PA) and of urokinase-type PA (u-PA) activity. PA inhibitor (PAI) activity was higher in the plasma of aged rats, as was t-PA activity in lung and heart.Rats were treated with either a low dose (1 μg/kg) or a high dose (10 mg/kg) of endotoxin. Both treatments induced a transient phase of increased blood fibrinolytic activity, as evidenced by higher levels of tissue-type plasminogen activator (t-PA) activity and decreased levels of PA inhibitor (PAI) activity. Over time, the fibrinolytic activity decreased, probably due to increased levels of PA inhibitor.Both the early increase in t-PA activity, and the subsequent increase in PAI activity, were more pronounced in the aged rats, as compared with the younger rats, after the high dose of endotoxin. The aged rats also responded to an injection of interleukin-1β or tumor necrosis factor-α with a larger increase of PAI activity than did the younger rats.Together the data suggest that, compared to young rats, aged rats have a decreased base-line plasma fibrinolytic activity, while their fibrinolytic system is more responsive to challenge by endotoxin and cytokines.

Accelerated infarct development, cytogenesis and apoptosis following cerebral ischaemia in aged rats

2006 ◽  
Vol 33 (S 1) ◽  
Author(s):  
A. Popa-Wagner ◽  
M. Sascau ◽  
Y. Suofu ◽  
C. Kessler
Keyword(s):  
Cerebral Ischaemia ◽  
Aged Rats

Impact of Various Regimens of Rhythmic Extreme Cold Exposures on Hormone and Lipid Content in Blood Serum of Young and Aged Rats

2019 ◽  
Vol 29 (3) ◽  
pp. 206-220
Author(s):  
Volodymyr Kulik ◽  
◽  
Georgiy Babiichuk ◽  
Vladyslav Babiichuk ◽  
Natalya Malova ◽  
...  
Keyword(s):  
Blood Serum ◽  
Lipid Content ◽  
Aged Rats ◽  
Extreme Cold

Protective Effects of Exercise Training Against Aged Induced the Reduction of Cardiac Angiogenic Capacity in Middle Aged Rats

2020 ◽  
Vol 04 (01) ◽  
Author(s):  
Titiporn Mekrungruangwong ◽  
Pimpetch Kasetsuwan ◽  
Sheepsumon Viboolvorakul ◽  
Suthiluk Patumraj
Keyword(s):  
Exercise Training ◽  
Protective Effects ◽  
Aged Rats ◽  
Middle Aged
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