Review of full blood count reference interval using a large cohort of first-time plasmapheresis blood donors

Pathology ◽  
2020 ◽  
Author(s):  
Rena Hirani ◽  
Phillip Mondy
Keyword(s):  
Blood Count ◽  
Blood Donors ◽  
Reference Interval ◽  
Large Cohort ◽  
Full Blood Count ◽  
First Time ◽  
Count Reference

Interaction of Hematological Analysis and α-globin Genotypes among Eligible Blood Donors

2020 ◽  
Vol 19 (3) ◽  
Author(s):  
Lai Kuan Teh ◽  
Li Fang Lim ◽  
Yu Leong Teh ◽  
Elizabeth George ◽  
TzeYan Lee ◽  
...  
Keyword(s):  
Blood Count ◽  
Blood Donors ◽  
Full Blood Count ◽  
Haematological Parameter ◽  
Molecular Characterisation ◽  
Globin Chain ◽  
Significant Difference ◽  
Hematological Analysis ◽  
Alpha Thalassaemia ◽  
Rule Out

Introduction: Alpha thalassaemia is one of the haemoglobin disorders in which the carriers of alpha thalassaemia may have normal haemoglobin level and are eligible to donate blood which may bring complications. This study is to investigate the interaction of haematological parameter with α-globin genotypes among eligible blood donors. Materials & Methods: A cohort study with 270 eligible blood donors were analysed for red cell indices. Alpha-globin (α-globin) genotyping was performed for seven deletions, six point mutations and two triplications. Statistical analyses were performed to compare the α-globin genotypes with haematological data. Results: High prevalence of α-thalassaemia carriers (7.7%, 21/270) was found among blood donors. All of them did not show anaemic pictures with a normal Hb level (>12 gm/dl). Five genotypes were identified consisting of 249 αα/αα (92.2%), nine -α 3.7/αα (3.3%), nine-- SEA/αα (3.3%), two -α 4.2/αα (0.7%) and one ααCS/αα (0.4%). Different α-globin genotypes showed a significant difference in RBC, MCV, MCH, MCHC, RDW, and Hct/Hb ratio (p<0.05) due to the different extent of α-globin chain reduction. Conclusion: Our study concluded that by using Hb level alone is not sufficient to screen for the eligibility of blood donors. Full blood count (FBC) screening with borderline MCV and MCH levels might be able to rule out silent α-thalassemia carriers. FBC and molecular characterisation should be incorporated together to properly rule out α-thalassaemia carriers.><0.05) due to the different extent of α-globin chain reduction. Conclusion: Our study concluded that by using Hb level alone is not sufficient to screen for the eligibility of blood donors. Full blood count (FBC) screening with borderline MCV and MCH levels might be able to rule out silent α-thalassemia carriers. FBC and molecular characterisation should be incorporated together to properly rule out α-thalassaemia carriers.

scholarly journals Prevalence of Iron Deficiency, Iron Deficiency Anaemia and General Anaemia in Male Gambian Blood Donors Residing in Greater Banjul Region

2021 ◽  
Author(s):  
Mustapha Dibbasey ◽  
Bolarinde Lawal ◽  
Solomon Umukoro ◽  
Peter Mitchel
Keyword(s):  
Iron Deficiency ◽  
Blood Donor ◽  
Iron Deficiency Anaemia ◽  
Blood Count ◽  
Blood Donors ◽  
Blood Donation ◽  
Full Blood Count ◽  
Serum Samples ◽  
Deficiency Anaemia ◽  
Donor Population

AbstractObjectiveThe objective of this study is to determine the prevalence of iron deficiency (ID) and iron deficiency anaemia (IDA) as well as general anaemia in male blood donors and their association with ageing process.Methodology and ResultsA total of two hundred and one (201) serum samples were analysed for ferritin in male Gambian blood donors. The ferritin measurement was achieved with COBAS® INTEGRA 400 plus. At the same time, haemoglobin values were retrospectively obtained from the archived haematological full blood count result in the GARIS database. IDA was defined as (Haemoglobin <13.0g/dL+ Ferritin<15ng/ml) whilst ID was defined as (Haemoglobin ≥13.0g/dL+ Ferritin<15ng/ml) and general anaemia was defined as haemoglobin <13.0g/dL in males. The prevalence of anaemia (20%, n=41), ID (22%, n=44) and IDA (10%, n=21), were recorded in male donors. The results show no relationship between ferritin and haemoglobin among the blood donors (collection coefficient (r) = 0.04). Besides, no linear association of having anaemia and ID with ageing was reported among the blood donor population.Conclusion and potential application of findingsID and IDA as well as general anaemia are highly prevalent among blood donors in the Gambia. Besides, no predisposition to ID and anaemia was observed in term of age, thus all blood donors from 18-60 should be considered for blood donation without any age preference.

Complete Blood Count Reference Interval Diagrams Derived from NHANES III: Stratification by Age, Sex, and Race

2004 ◽  
Vol 10 (1) ◽  
pp. 42-53 ◽  
Author(s):  
Calvino Ka-Wing Cheng ◽  
Julie Chan ◽  
George S. Cembrowski ◽  
Onno W. Van Assendelft
Keyword(s):  
Blood Count ◽  
Complete Blood Count ◽  
Reference Interval ◽  
Nhanes Iii ◽  
Count Reference

SEROPREVALENCE OF HIV AND HBsAg AMONGST BLOOD DONORS IN A TERTIARY CARE HOSPITAL, CHHATTISGARH.

2019 ◽  
Vol 3 (8) ◽  
Author(s):  
Anusha P ◽  
Bankar Nandkishor J ◽  
Karan Jain ◽  
Ramdas Brahmane ◽  
Dhrubha Hari Chandi
Keyword(s):  
Hepatitis B ◽  
Blood Donors ◽  
Hepatitis B Surface Antigen ◽  
Tertiary Care ◽  
Laboratory Diagnosis ◽  
Blood Bank ◽  
Care Hospital ◽  
Medical College ◽  
The World ◽  
First Time

INTRODUCTION: India being the second highly populated nation in the world. HIV/AIDS has acquired pandemic proportion in the world. Estimate by WHO for current infection rate in Asia. India has the third largest HIV epidemic in the world. HIV prevalence in the age group 15-49 yrs was an estimate of 0.2%. India has been classified as an intermediate in the Hepatitis B Virus (HBV) endemic (HBsAg carriage 2-7%) zone with the second largest global pool of chronic HBV infections. Safety assessment of the blood supply, the quality of screening measures and the risk of transfusion transmitted infectious diseases (TTIs) in any country can be estimated by scrutinizing the files of blood donors. After the introduction of the blood banks and improved storage facilities, it became more extensively used. Blood is one of the major sources of TTIs like hepatitis B, hepatitis C, HIV, syphilis, and many other blood borne diseases. Disclosure of these threats brought a dramatic change in attitude of physicians and patients about blood transfusion. The objective of this study is to determine the seroprevalence of transfusion transmitted infections amidst voluntary blood donors at a rural tertiary healthcare teaching hospital in Chhattisgarh. MATERIAL AND METHODS: This retrospective study was carried out in Chandulal Chandrakar Memorial Medical College, Kachandur, Durg. Blood donors were volunteers, or and commercial donors who donated the blood and paid by patients, their families, or friends to replace blood used or expected to be used for patients from the blood bank of the hospital. After proper donation of blood routine screening of blood was carried out according to standard protocol. Laboratory diagnosis of HIV 1 and HIV 2 was carried out by ELISA test. Hepatitis B surface antigen was screened by using ELISA. RESULTS: A total of 1915 consecutive blood donors’ sera were screened at Chandulal Chandrakar Memorial Medical College, blood bank during study period. Of these 1914 were male and 1 female. The mean age of patients was found to be 29.34 years with standard deviation (SD) of 11.65 Years. Among all blood donors in present study, 759(39.63%) were first time donors and 1156(60.37%) were repeated donors. 1 patient was HIV positive in first donation group while 3 (75%) were positive in repeat donation group. 7 (38.9%) were HBsAg positive in in first donation group while 11(61.1%) were positive in repeat donation group. Two patients in first donation group had dual infection of HIV and HBsAg. CONCLUSION: Seropositivity was high in repeated donors as compared to first time donors. The incidence of HIV is observed to be 0.2% and that of HBsAg is 0.94%. Strict selection of blood donors should be done to avoid transfusion-transmissible infections during the window period.

Demographic, clinical, and biochemical predictors of pica in a large cohort of blood donors

Transfusion ◽  
2021 ◽  
Author(s):  
Hefei Liu ◽  
Robert T. Burns ◽  
Bryan R. Spencer ◽  
Grier P. Page ◽  
Alan E. Mast ◽  
...  
Keyword(s):  
Blood Donors ◽  
Large Cohort

Caffeine attenuates vasovagal reactions in female first-time blood donors.

1999 ◽  
Vol 18 (4) ◽  
pp. 403-409 ◽  
Author(s):  
Lori A. Sauer ◽  
Christopher R. France
Keyword(s):  
Blood Donors ◽  
Vasovagal Reactions ◽  
First Time
Sign in / Sign up

Export Citation Format

Share Document