Complete Blood Count Reference Interval Diagrams Derived from NHANES III: Stratification by Age, Sex, and Race

2004 ◽  
Vol 10 (1) ◽  
pp. 42-53 ◽  
Author(s):  
Calvino Ka-Wing Cheng ◽  
Julie Chan ◽  
George S. Cembrowski ◽  
Onno W. Van Assendelft
Keyword(s):  
Blood Count ◽  
Complete Blood Count ◽  
Reference Interval ◽  
Nhanes Iii ◽  
Count Reference

scholarly journals Dark brown serum and plasma samples

2020 ◽  
Vol 30 (2) ◽  
pp. 320-324
Author(s):  
Lora Dukic ◽  
Nikolina Maric ◽  
Ana-Maria Simundic
Keyword(s):  
Blood Count ◽  
Complete Blood Count ◽  
Reference Interval ◽  
Serum Samples ◽  
Arterial Blood Gas ◽  
Arterial Blood ◽  
Reflex Testing ◽  
Colicky Pain ◽  
Hb Concentration

This case report describes occurrence of unusual, dark brown coloration of citrate plasma and serum samples in a female 68 years old patient admitted into Emergency department (ED). Patient complained of nausea and vomiting, fever up to 38.9°C, colicky pain in abdomen, diminished urinary output and yellowish skin tone. Her medical history included arterial hypertension, hypothyroidism and facial squamous cell carcinoma. For previous two years, she was treated with tuberculostatic therapy for Mycobacterium avium positive interstitial lung disease. Regular follow-up showed no signs of active disease. Upon admission to ED, complete blood count (CBC) analysis showed low red blood count (RBC) (3.76 x1012/L (reference interval (RI) 3.86 – 5.08 x1012/L)), low haemoglobin (Hb) concentration (111 g/L (RI 119 - 157 g/L)) and low haematocrit (Hct) (0.310 L/L (RI 0.360 – 0.470 L/L)). Biochemistry analytes were high, with foremost lactate dehydrogenase (LD) activity (2900 U/L, RI < 240 U/L). After communication with the clinician, methaemoglobin measured in arterial blood gas sample was reported. Patient was admitted to the Intensive care unit and upon reflex testing of haptoglobin, intravascular haemolysis was confirmed. This case indicates that every case of brown coloration of the serum must be promptly communicated to the clinician. Reflex testing assured timely diagnosis and favourable patient outcome.

scholarly journals Complete Blood Count Reference Values of Donated Cord Blood from Korean Neonates

2009 ◽  
Vol 29 (3) ◽  
pp. 179-184 ◽  
Author(s):  
Hye Ryun Lee ◽  
Sue Shin ◽  
Jong Hyun Yoon ◽  
Byoung Jae Kim ◽  
Kyu Ri Hwang ◽  
...  
Keyword(s):  
Cord Blood ◽  
Reference Values ◽  
Blood Count ◽  
Complete Blood Count ◽  
Count Reference

scholarly journals A Comparison of Complete Blood Count Reference Intervals in Healthy Elderly Versus Younger Korean Adults: A Large Population Study

Blood ◽  
2018 ◽  
Vol 132 (Supplement 1) ◽  
pp. 4708-4708
Author(s):  
Young Kyung Lee ◽  
Eun Jin Lee ◽  
Miyoung Kim ◽  
Eunyup Lee ◽  
Kibum Jeon ◽  
...  
Keyword(s):  
Blood Count ◽  
Complete Blood Count ◽  
Conflicts Of Interest ◽  
Large Population ◽  
Age Groups ◽  
Reference Interval ◽  
Reference Intervals ◽  
Healthy Elderly ◽  
Elderly Koreans ◽  
Lower Limits

Abstract Background: The use of laboratory reference intervals based on younger populations is of questionable validity in older populations. We established reference intervals for 16 complete blood count (CBC) parameters in healthy elderly Koreans aged ≥60 years and compared them to those of individuals aged 20-59 years. Methods: Among 64,532 individuals (39,609 men and 24,923 women) aged ≥20 years who underwent medical check-ups, 8,151 healthy subjects (12.6%, 5,270 men and 2,881 women, including 675 and 511, respectively, who were ≥60 years of age) were enrolled based on stringent criteria including laboratory, imaging, and endoscopy results; previous medical history; and medication history. CBC parameters were measured using an Advia2120i instrument. The difference between 2 age groups in subjects of each sex was compared using the Mann-Whitney U-test. P-values <0.05 were considered statistically significant. The reference intervals for measured CBC parameters were established according to a nonparametric method based on the CLSI EP28A-3C in each subgroup. The 90% confidence intervals for the upper and lower limits of each reference interval were calculated; the Reed method was used to remove extreme outliers. The Harris and Boyd method was used to determine the necessity of separating the reference intervals for different age groups within each sex group. To identify reference intervals in different age groups in individuals aged 60 years and over, such individuals of each sex were subdivided into 5 age subgroups with 5-year age interval: since the sizes of 4 of these subgroups were not sufficiently large, we used the Robust method. Results: A statistical difference in the medians of the following parameters were observed between the <60- and ≥60-year age groups: RBC, Hb, hematocrit (Hct), basophils, and platelets in men aged <60 years were higher than those in men aged ≥60 years; furthermore, MCV, MCH, and RDW in men aged ≥60 years were higher than those in men aged <60 years. Neutrophils in women aged <60 years were higher than in those aged ≥60 years. Hb, Hct, MCV, MCH, MCHC, lymphocytes, and basophils in women aged ≥60 years were higher than in those aged <60 years. Separate reference intervals were required only for RDW and MCH in women ≥60 from those < 60 years of age. Men aged ≥60 years versus those <60 years did not require separate reference intervals for any of the 16 measured parameters. In subjects aged ≥60 years, RBC, Hb, Hct, MCV, MCH, MCHC, RDW, WBC, neutrophils, monocytes, eosinophils, MPV, and PDW were higher in men than in women, while the opposite was true for lymphocytes and platelets. Partitioning of reference intervals by sex was required for RBC, Hb, Hct, MCH, monocytes, and eosinophils. In men, median values and the lower limits of the reference intervals for RBC, Hb, and Hct tended to decrease with advancing age. The upper and lower limits of reference intervals for WBC, neutrophils, lymphocytes, and MPV also showed increasing and decreasing tendencies, respectively, widening the reference intervals as the subjects aged (except in the 70-74-year-old group for men). Among women, the lower limits of the reference intervals for RBC, Hb, and Hct showed a tendency to decrease with increasing age for those >70 years of age; however, the median values did not show such a tendency. The reference interval for PDW narrowed as women aged. Separate reference intervals were required among men for MCH and eosinophils in the 70-74-year group, and for basophils in the 65-69-year group. Among women, separate reference intervals were required for MCV in the 65-69-year group; for MCH in the 60-64, 65-69, and ≥75-years groups; and for RDW in all the 4 elderly age subgroups. Conclusion: Healthy elderly Koreans can use the same reference intervals as younger populations. Thus, abnormal CBC results may not necessarily be attributable to physiologic changes but possible underlying diseases that should be investigated. Disclosures No relevant conflicts of interest to declare.

scholarly journals Complete blood count reference intervals from a healthy adult urban population in Kenya

PLoS ONE ◽  
2018 ◽  
Vol 13 (6) ◽  
pp. e0198444 ◽  
Author(s):  
Geoffrey Omuse ◽  
Daniel Maina ◽  
Jane Mwangi ◽  
Caroline Wambua ◽  
Kiran Radia ◽  
...  
Keyword(s):  
Urban Population ◽  
Blood Count ◽  
Healthy Adult ◽  
Complete Blood Count ◽  
Reference Intervals ◽  
Count Reference

scholarly journals Complete Blood Count Reference Intervals for Healthy Han Chinese Adults

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0119669 ◽  
Author(s):  
Xinzhong Wu ◽  
Min Zhao ◽  
Baishen Pan ◽  
Jie Zhang ◽  
Mingting Peng ◽  
...  
Keyword(s):  
Blood Count ◽  
Complete Blood Count ◽  
Reference Intervals ◽  
Han Chinese ◽  
Chinese Adults ◽  
Count Reference

Retrospective Study on the Effects of Long-Term Use of Methylprednisolone Acetate on the Blood Work of 25 Cats

2019 ◽  
Vol 55 (1) ◽  
pp. 23-28
Author(s):  
Joanne Sohn ◽  
Theresa Gruber ◽  
Gaylord M. Brown
Keyword(s):  
Retrospective Study ◽  
Blood Count ◽  
Complete Blood Count ◽  
Reference Interval ◽  
Parenteral Administration ◽  
Methylprednisolone Acetate ◽  
Abnormal Laboratory ◽  
Laboratory Values

ABSTRACT Twenty-five cats at a private animal sanctuary received multiple nonimmunosuppressive doses of parenteral methylprednisolone acetate for at least 3 yr. Complete blood count, chemistry, and T4 results from these cats were examined to look for statistically significant changes. Results found significant changes in triglycerides, amylase, and monocytes. However, these changes remained within the reference interval. All other values showed no significant changes. These results suggest that after 3 yr of chronic parenteral administration of nonimmunosuppressive doses of methylprednisolone acetate, the complete blood count, chemistry, and T4 values in 25 cats were not significantly affected and did not result in abnormal laboratory values.

scholarly journals Establish Reference Intervals of Complete Blood Count for Twin Pregnancy

2021 ◽  
Author(s):  
Yifan Zeng ◽  
Lei Li ◽  
Man Mao ◽  
Xinghua Liang ◽  
Min Chen ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Twin Pregnancy ◽  
Blood Count ◽  
Complete Blood Count ◽  
Reference Interval ◽  
Reference Intervals ◽  
Adverse Outcomes ◽  
Adverse Pregnancy ◽  
Reference Cohort ◽  
Normal Twin

Abstract Background: Twin pregnancy is of high risk, which increased in recent years. Establishment of reference intervals of complete blood count (CBC) for twin-pregnant women during pregnancy might help for the properly prognosis of adverse outcomes in twin pregnancy. Methods: We screened out 253 cases of twin pregnancy reference cohort from 1153 twin pregnancy after the complications and adverse pregnancy outcomes were excluded. Complete blood count data were collected during the mid- and late-term of pregnancy and analyzed by SPSS to establish the reference intervals of peripheral blood of twin pregnancy. Results: The RBC, HGB, HCT, and PLT were lower in twin pregnant women than those in healthy nulligravida women during gestation, while the levels of WBC, NEU, and NEU% increased, especially in the mid-term. The reference intervals of late-term pregnancy validated by using 20 samples of twin pregnancy, then utilized for figuring out the distinctive characteristics of CBC with preterm birth (PTB) pregnancy. Absolutes of WBC and NEU increased in PTB pregnancy using our established reference intervals, implying they might be prognosis indicators of this adverse outcome. Conclusion: Establishing the reference interval of blood cell-related indicators of normal twin pregnancy is helpful for the monitoring and prognosis of PTB.

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