Oligosarcoma, an unusual biphasic tumour

Pathology ◽  
2020 ◽  
Vol 52 ◽  
pp. S72
Author(s):  
Lauren Furnas ◽  
Thomas Robertson ◽  
Edwin Tan
Keyword(s):  
Biphasic Tumour

BIPHASIC TUMOUR-ENHANCING AND TUMOUR-INHIBITING EFFECTS OF NONSPECIFIC IMMUNOTHERAPY

The Lancet ◽  
1975 ◽  
Vol 305 (7916) ◽  
pp. 1138
Author(s):  
Israel Siegel ◽  
MichaelH. Grieco ◽  
JanetV. Rice
Keyword(s):  
Biphasic Tumour

scholarly journals Clinicopathological and immunohistochemical analysis of Sarcomatoid carcinoma of head and neck mucosal region: a retrospective analysis

2019 ◽  
Vol 7 (2) ◽  
pp. 561
Author(s):  
Sumaira Qayoom ◽  
Naseem Akhtar ◽  
Madhu Kumar ◽  
Preeti Agarwal ◽  
Malti Kumari Maurya ◽  
...  
Keyword(s):  
Head And Neck ◽  
Spindle Cell ◽  
Treatment Guidelines ◽  
Clinical Stage ◽  
Sarcomatoid Carcinoma ◽  
Immunohistochemical Analysis ◽  
Biphasic Tumour ◽  
The Mean ◽  
One Year

Background: Sarcomatoid carcinoma is a biphasic tumour comprising both of malignant epithelial and mesenchymal elements derived monoclonally from same stem cells. These are unusual variants of squamous cell carcinoma and constitute less than 1% of the head and neck mucosal tumors. Only few studies have been published and needs more understanding to establish treatment guidelines. The aim of this study was to review the cases of carcinosarcoma arising from mucosal sites of head and neck and study their clinical, histological and Immunohistochemical features.Methods: Retrospective data and slides of histologically proven sarcomatoid carcinoma over a period of thirty -four months between January 2016 - October 2018 were retrieved and evaluated for various clinical and histopathological parameters.Results: Total of 22 cases were included in the study and the mean age of presentation was 58years with male: female ration 2:1. Most of the patients (81.8%) presented with a mass lesion of less than 6 months duration. The most common site was oral cavity (68.1%) followed by larynx (22.7%). Clinical stage was known in eleven cases. One case presented with pulmonary metastasis. Histopathologically, epithelial differentiation was identified in nine cases (41%) on morphology and in thirteen cases could be highlighted by cytokeratin positivity. The Mesenchymal component was arranged in sheets (63.7%) and fascicles (31.8%). Marked anaplasia and brisk mitosis wereseen in 54.5% and 19.3% respectively.  On immunohistochemistry all 22 cases were positive for Vimentin, twenty cases were positive for cytokeratin/EMA and aberrant mesenchymal markers were expressed in 10% of cases.  Follow up was available in eighteen cases out of which fourteen cases died within one year of diagnosis.Conclusions: Diagnosis of sarcomatoid carcinoma is challenging especially on small biopsy because of overlapping features with other spindle cell tumors. Understanding the clinicopathological features facilitates their diagnosis and effective clinical management.

scholarly journals Sarcomatoid Carcinoma of the Prostate: Ductal Adenocarcinoma and Stromal Sarcoma-Like Appearance: A Rare Association

2011 ◽  
Vol 2011 ◽  
pp. 1-6
Author(s):  
David Parada ◽  
Karla B. Peña ◽  
Francesc Riu
Keyword(s):  
Prostate Gland ◽  
Sarcomatoid Carcinoma ◽  
Progesterone Receptors ◽  
Giant Cells ◽  
Clinical Findings ◽  
Ductal Adenocarcinoma ◽  
Rare Tumour ◽  
Pleomorphic Sarcoma ◽  
Stromal Sarcoma ◽  
Biphasic Tumour

Sarcomatoid carcinoma (SC) of prostate gland is a rare biphasic tumour. In about half of cases, initial diagnosis is acinar adenocarcinoma, followed by nonsurgical therapy, with a subsequent diagnosis of SC. The survival rate is lower. We report a case of an 59-years-old man with unusual histopathologic finding of prostate sarcomatoid carcinoma, showing characteristics of ductal prostatic adenocarcinoma and prostatic stromal sarcoma-like appearance. Ductal adenocarcinoma was characterized by tall columnar cells with abundant amphophilic to eosinophil cytoplasm. Pleomorphic sarcoma was characterized to have overall glandular growth pattern, simulating a malignant phyllodes tumour. Estrogen and progesterone receptors showed nuclear immunostaining in mesenchymal multinucleated giant cells. In conclusion, SC of the prostate is an exceedingly rare tumour. Retrospective analyses render prostate SC as one of the most aggressive prostate malignancies. The prognosis is dismal regardless of other histologic or clinical findings.

True carcinosarcoma of the larynx

2012 ◽  
Vol 127 (1) ◽  
pp. 100-103 ◽  
Author(s):  
M Zhang ◽  
L-M Zhao ◽  
X-M Li ◽  
L Zhou ◽  
L Lin ◽  
...  
Keyword(s):  
Neck Dissection ◽  
Radical Neck Dissection ◽  
Clinical Information ◽  
Distant Metastases ◽  
Partial Laryngectomy ◽  
Cervical Lymph Nodes ◽  
Complete Surgical Resection ◽  
Biphasic Tumour ◽  
Male Patients

AbstractObjective:To explore the diagnosis and treatment of carcinosarcoma of the larynx.Methods:Clinical information, including presentation, pathology, treatment and outcome, was obtained from a review of patient charts.Results:Seven male patients were confirmed pathologically to have had carcinosarcoma between 2003 and 2009 in our hospital. All patients underwent surgery: four total laryngectomies, two vertical partial laryngectomies, and one supracricoid partial laryngectomy-cricohyoidopexy. The mean follow up was 40.6 months. At the time of writing, six patients were alive and being followed; two of these suffered regional metastasis to the cervical lymphatic nodes and underwent radical neck dissection. One patient died of multiple distant metastases 60 months post-operatively.Conclusion:Carcinosarcoma of the larynx describes a biphasic tumour showing both carcinomatous and sarcomatous differentiation. It is extraordinarily rare and prone to metastasise to the cervical lymph nodes. Complete surgical resection of laryngeal primary lesions with wide margins and suitable neck dissection of cervical nodes is reasonable therapy.

scholarly journals Malignant mixed mullerian tumour: A brief communication

1970 ◽  
Vol 2 (1) ◽  
pp. 74-78
Author(s):  
Dibya S Malla ◽  
Achala Vaidya ◽  
Prabhaker Kumar
Keyword(s):  
Electron Microscopy ◽  
Malignant Diseases ◽  
Malignant Mixed Mullerian Tumor ◽  
Malignant Mixed Müllerian Tumor ◽  
Menopausal Women ◽  
Biphasic Tumour ◽  
Mixed Müllerian Tumor ◽  
Mixed Mullerian Tumor ◽  
Malignant Mixed Mullerian Tumour ◽  
Mullerian Tumor

Carcinosarcoma is a Malignant mixed mullerian tumor (MMT) originating from the mesothelium and mesenchyme of embryonic mesoderm, now better established by electron microscopy and immuno-peroxidase techniques. The most interesting aspects in the histogenesis of this biphasic tumour mostly monoclonal in origin are briefly communicated in this paper. Unfortunately, no adjuvant chemo or radiotherapy for either persistent or recurrent malignant diseases has ever resulted in cure of this aggressive tumour, usually seen in menopausal women. Key words: Malignant mixed mullerian tumor (MMT), carcinosarcoma, menopause.     doi:10.3126/njog.v2i1.1484 N. J. Obstet. Gynaecol Vol. 2, No. 1, p. 74 - 78 May -June 2007

Successful surgical treatment of a prostatic biphasic tumour (sarcomatoid carcinoma) in a cat

2010 ◽  
Vol 12 (2) ◽  
pp. 161-165 ◽  
Author(s):  
Daniele Zambelli ◽  
Marco Cunto ◽  
Ramona Raccagni ◽  
Barbara Merlo ◽  
Maria Morini ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Sarcomatoid Carcinoma ◽  
Biphasic Tumour

Epithelial-myoepithelial carcinoma of the parotid gland: a case report and review of the cytological and histological features

2001 ◽  
Vol 115 (5) ◽  
pp. 434-436 ◽  
Author(s):  
H. Deere ◽  
I. Hore ◽  
N. McDermott ◽  
T. Levine
Keyword(s):  
Parotid Gland ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Myoepithelial Carcinoma ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Biphasic Tumour ◽  
Needle Aspiration Cytology ◽  
Epithelial Myoepithelial Carcinoma

Epithelial-myoepithelial carcinoma (EMC) is a rare biphasic tumour of the salivary glands typically arising in the parotid. Fine needle aspiration cytology is widely used in the initial investigation of salivary gland swellings and whilst the cytological features of this tumour have been described they are not well recognized. This report describes the clinicopathological features of a case of epithelial-myoepithelial carcinoma of the parotid gland and highlights the importance of awareness of this tumour in the differential diagnosis of biphasic tumours on fine needle aspiration cytology.

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