Tumour mismatch repair protein loss is associated with advanced stage in oral cavity squamous cell carcinoma

Pathology ◽  
2019 ◽  
Vol 51 (7) ◽  
pp. 688-695 ◽  
Author(s):  
Kartik Vasan ◽  
Laveniya Satgunaseelan ◽  
Sunaina Anand ◽  
Rebecca Asher ◽  
Christina Selinger ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Mismatch Repair ◽  
Squamous Cell ◽  
Advanced Stage ◽  
Protein Loss ◽  
Repair Protein ◽  
Mismatch Repair Protein

Mismatch repair protein loss in cutaneous head and neck squamous cell carcinoma

2020 ◽  
Vol 122 (8) ◽  
pp. 1755-1760
Author(s):  
Kartik Vasan ◽  
Sunaina Anand ◽  
Laveniya Satgunaseelan ◽  
Rebecca Asher ◽  
Hubert Low ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Mismatch Repair ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Protein Loss ◽  
Repair Protein ◽  
Mismatch Repair Protein

Reduced human mismatch repair protein expression in the development of precancerous skin lesions to squamous cell carcinoma

2001 ◽  
Vol 439 (5) ◽  
pp. 622-627 ◽  
Author(s):  
Sheng-Ben Liang ◽  
Mutsuo Furihata ◽  
Tamotsu Takeuchi ◽  
Hiroshi Sonobe ◽  
Yuji Ohtsuki
Keyword(s):  
Squamous Cell Carcinoma ◽  
Protein Expression ◽  
Cell Carcinoma ◽  
Mismatch Repair ◽  
Squamous Cell ◽  
Skin Lesions ◽  
Repair Protein ◽  
Mismatch Repair Protein

scholarly journals No Evidence of Microsatellite Instability and Loss of Mismatch-Repair-Protein Expression in Squamous Cell Carcinoma of the Penis

Pathobiology ◽  
2019 ◽  
Vol 86 (2-3) ◽  
pp. 145-151 ◽  
Author(s):  
Robert Stoehr ◽  
Olaf Wendler ◽  
Johannes Giedl ◽  
Nadine T. Gaisa ◽  
Georg Richter ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Protein Expression ◽  
Microsatellite Instability ◽  
Cell Carcinoma ◽  
Mismatch Repair ◽  
Squamous Cell ◽  
Repair Protein ◽  
Mismatch Repair Protein

scholarly journals To evaluate disparity between clinical and pathological tumor-node-metastasis staging in oral cavity squamous cell carcinoma patients and its impact on overall survival: An institutional study

2015 ◽  
Vol 04 (04) ◽  
pp. 183-185 ◽  
Author(s):  
Karan Gupta ◽  
Naresh K Panda ◽  
Jaimanti Bakshi ◽  
Ashim Das
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Early Stage ◽  
Tnm Staging ◽  
Advanced Stage ◽  
Tumor Node Metastasis ◽  
Node Metastasis ◽  
N Stage

Abstract Background: Accurate clinical staging is important for patient counseling, treatment planning, prognostication, and rational design of clinical trials. In head and neck squamous cell carcinoma, discrepancy between clinical and pathological staging has been reported. Objective: To evaluate any disparity between clinical and pathological tumor-node-metastasis (TNM) staging in oral cavity squamous cell carcinoma (OCSCC) patients and any impact of the same on survival. Materials and Methods: Retrospective chart review from year 2007 to 2013, at a tertiary care center. Statistical Analysis: All survival analyses were performed using SPSS for Windows version 15 (Chicago, IL, USA). Disease-free survival curves were generated using Kaplan-Meier algorithm. Results: One hundred and twenty-seven patients with OCSCC were analyzed. Seventy-nine (62.2%) were males and 48 (37.8%) females with a mean age at presentation 43.6 years (29-79 years). The highest congruence between clinical and pathological T-staging seen for clinical stage T1 and T4 at 76.9% and 73.4% with pathological T-stage. Similarly, the highest congruence between clinical and pathological N-stage seen for clinical N0 and N3 at 86.4% and 91.7% with pathological N-stage. Of clinically early stage patients, 67.5% remained early stage, and 32.5% were upstaged to advanced stage following pathological analysis. Of the clinically advanced stage patients, 75% remained advanced, and 25% were pathologically downstaged. This staging discrepancy did not significantly alter the survival. Conclusion: Some disparity exists in clinical and pathological TNM staging of OCSCC, which could affect treatment planning and survival of patients. Hence, more unified and even system of staging for the disease is required for proper decision-making.

scholarly journals Multi-institutional investigation of the prognostic value of lymph nodel yield in advanced-stage oral cavity squamous cell carcinoma

Head & Neck ◽  
2014 ◽  
pp. n/a-n/a
Author(s):  
James J. Jaber ◽  
Chad A. Zender ◽  
Vikas Mehta ◽  
Kara Davis ◽  
Robert L. Ferris ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Advanced Stage

scholarly journals Pathways to Diagnosis and Treatment of Patients With Oropharynx, Oral Cavity, and Cutaneous Squamous Cell Carcinoma in New South Wales, Australia

2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 41s-41s
Author(s):  
R. Venchiarutti ◽  
J. Clark ◽  
C. Palme ◽  
M. Solomon ◽  
J. Young
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
New South ◽  
New South Wales ◽  
Diagnosis And Treatment ◽  
Advanced Stage ◽  
Remote Areas ◽  
South Wales

Background: Early cancer diagnosis is a critical component of comprehensive cancer control, however more than 50% of head and neck cancers (HNCs) are diagnosed at advanced stage. HNC patients from regional/remote areas are less likely to use radiotherapy during treatment and have poorer survival outcomes than metropolitan patients. Aim: The aim of this study was to examine pathways to treatment of patients with HNC in New South Wales (NSW) and associations between duration of components of the pathway with survival. Methods: Patients diagnosed with squamous cell carcinoma (SCC) of the oral cavity, oropharynx, or cutaneous SCC from 1st July 2008 to 30th June 2013 were identified from a prospectively maintained database. Data were extracted and supplemented by a retrospective audit of medical records at Royal Prince Alfred Hospital and specialists' records. Results: Two hundred and fifty eligible patients were identified (78% male) with mean (SD) age at diagnosis 64.5 (13.5) years. At diagnosis, 75%, 24% and 1% lived in metropolitan, regional and remote areas of NSW, respectively. Twelve per cent of patients lived > 100 km from a hospital with a HNC multidisciplinary team (median [IQR] 7.5 km [25.1]). More than two-thirds (69%) of tumors were diagnosed as advanced stage, and mean follow-up time was 3.5 years. We will present additional findings quantifying intervals along the pathway to treatment (from symptom onset, first specialist visit, diagnosis and treatment), and the associations with survival, and compare findings to those from a second regional site on the mid north coast of NSW. Conclusion: An increasing proportion of the NSW population resides outside major cities. This study is the first step in understanding patient and health system factors that facilitate and impede early diagnosis of HNC. Findings from this study may be used to develop interventions aimed at improving early HNC diagnosis.

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