Reduced human mismatch repair protein expression in the development of precancerous skin lesions to squamous cell carcinoma

2001 ◽  
Vol 439 (5) ◽  
pp. 622-627 ◽  
Author(s):  
Sheng-Ben Liang ◽  
Mutsuo Furihata ◽  
Tamotsu Takeuchi ◽  
Hiroshi Sonobe ◽  
Yuji Ohtsuki
Keyword(s):  
Squamous Cell Carcinoma ◽  
Protein Expression ◽  
Cell Carcinoma ◽  
Mismatch Repair ◽  
Squamous Cell ◽  
Skin Lesions ◽  
Repair Protein ◽  
Mismatch Repair Protein

scholarly journals No Evidence of Microsatellite Instability and Loss of Mismatch-Repair-Protein Expression in Squamous Cell Carcinoma of the Penis

Pathobiology ◽  
2019 ◽  
Vol 86 (2-3) ◽  
pp. 145-151 ◽  
Author(s):  
Robert Stoehr ◽  
Olaf Wendler ◽  
Johannes Giedl ◽  
Nadine T. Gaisa ◽  
Georg Richter ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Protein Expression ◽  
Microsatellite Instability ◽  
Cell Carcinoma ◽  
Mismatch Repair ◽  
Squamous Cell ◽  
Repair Protein ◽  
Mismatch Repair Protein

Mismatch repair protein loss in cutaneous head and neck squamous cell carcinoma

2020 ◽  
Vol 122 (8) ◽  
pp. 1755-1760
Author(s):  
Kartik Vasan ◽  
Sunaina Anand ◽  
Laveniya Satgunaseelan ◽  
Rebecca Asher ◽  
Hubert Low ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Mismatch Repair ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Protein Loss ◽  
Repair Protein ◽  
Mismatch Repair Protein

Tumour mismatch repair protein loss is associated with advanced stage in oral cavity squamous cell carcinoma

Pathology ◽  
2019 ◽  
Vol 51 (7) ◽  
pp. 688-695 ◽  
Author(s):  
Kartik Vasan ◽  
Laveniya Satgunaseelan ◽  
Sunaina Anand ◽  
Rebecca Asher ◽  
Christina Selinger ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Mismatch Repair ◽  
Squamous Cell ◽  
Advanced Stage ◽  
Protein Loss ◽  
Repair Protein ◽  
Mismatch Repair Protein

scholarly journals The Frequency of DNA Mismatch Repair Deficiency Is Very Low in Surgically Resected Lung Carcinoma

2021 ◽  
Vol 11 ◽  
Author(s):  
Naoki Yanagawa ◽  
Noriyuki Yamada ◽  
Ryo Sugimoto ◽  
Mitsumasa Osakabe ◽  
Noriyuki Uesugi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Protein Expression ◽  
Microsatellite Instability ◽  
Cell Carcinoma ◽  
Mismatch Repair ◽  
Squamous Cell ◽  
Lung Carcinoma ◽  
The Other ◽  
Dna Mismatch ◽  
Mmr Deficiency

IntroductionDNA mismatch repair (MMR) deficiency leads to changes in the length of nucleotide repeat sequences of tumor DNA. In that situation, DNA replicational errors occur and accumulate during DNA replication. As a result, this mechanism frequently affects the coding regions of oncogenes and tumor suppressor genes and causes carcinogenesis. Recently, DNA MMR deficiency has been recognized as a predictive biomarker for immunotherapy. The aim of this study is to examine the frequency of DNA MMR deficiency and clinicopathological characteristics in surgically resected lung carcinoma (LC) and their correlation.MethodsA total of 1153 LCs were examined. Tissue microarrays were constructed. The status of MMR deficiency was evaluated by immunohistochemical analysis of MMR protein expression (hMLH1, hMSH2, hMSH6, and hPMS2). Microsatellite instability analysis, BRAF mutation, and MLH1 methylation analysis were performed for cases that showed MMR deficiency.ResultsOnly 2 of the 1153 cases (0.17%) showed a loss of hMLH1/hPMS2 protein expression. They also had high levels of microsatellite instability (MSI-H), had neither MLH1 promoter methylation nor BRAF mutation, and were male smokers. Histopathologically, one was a squamous cell carcinoma, and the other was combined small cell carcinoma with squamous cell carcinoma. Regarding PD-L1 protein expression, one had high expression, and the other had none.ConclusionThe frequency of MMR deficiency was very low in LC. However, our two cases were non-adenocarcinoma and differed from previous studies. Because of its very low frequency, MMR deficiency is not a practical biomarker to predict the effect of immune checkpoint inhibitors in LC.

Mismatch Repair Protein Expression in Clear Cell Carcinoma of the Ovary

2016 ◽  
Vol 40 (5) ◽  
pp. 656-663 ◽  
Author(s):  
Jennifer A. Bennett ◽  
Vicente Morales-Oyarvide ◽  
Sharon Campbell ◽  
Teri A. Longacre ◽  
Esther Oliva
Keyword(s):  
Protein Expression ◽  
Cell Carcinoma ◽  
Mismatch Repair ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Repair Protein ◽  
Carcinoma Of The Ovary ◽  
Mismatch Repair Protein

scholarly journals Mismatch Repair Protein Expression and Microsatellite Instability in Cutaneous Squamous Cell Carcinoma

2021 ◽  
Vol 28 (5) ◽  
pp. 3316-3322
Author(s):  
Thilo Gambichler ◽  
Nomun Ganjuur ◽  
Andrea Tannapfel ◽  
Markus Vogt ◽  
Lisa Scholl ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Protein Expression ◽  
Microsatellite Instability ◽  
Cell Carcinoma ◽  
Mismatch Repair ◽  
Squamous Cell ◽  
Expression Profiles ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Small Subset ◽  
Low Level

There exist relatively sparse and conflicting data on high-level microsatellite instability (MSI-H) and deficient mismatch repair (dMMR) in cutaneous malignancies. We aimed to determine the expression profiles of MMR proteins (MSH2, MSH6, MLH1, and PMS2) in different progression stages of cutaneous squamous cell carcinoma (cSCC, 102 patients in total) by immunohistochemistry, and search for MSI-H in patients with low-level MMR or dMMR using multiplex-PCR. Low-level MMR protein expression was observed in five patients: One patient with primary cSCC < 2 mm thickness and low-level MLH1, three patients with primary cSCC > 6 mm (including one with low-level MSH2, as well as MSH6 expression, and two with low-level PMS2), and one patient with a cSCC metastasis showing low-level MSH2 as well as MSH6. Intergroup protein expression analysis revealed that MLH1 and MSH2 expression in actinic keratosis was significantly decreased when compared to Bowen’s disease, cSCC < 2 mm, cSCC > 6 mm, and cSCC metastasis. In cases with low-level MMR, we performed MSI-H tests revealing three cases with MSI-H and one with low-level MSI-L. We found low-level MMR expression in a small subset of patients with invasive or metastatic cSCC. Hence, loss of MMR expression may be associated with tumour progression in a small subgroup of patients with non-melanoma skin cancer.

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