Recent Advances in Follicular Lymphoma: Pediatric, Extranodal, and Follicular Lymphoma in Situ

2010 ◽  
Vol 3 (4) ◽  
pp. 877-906 ◽  
Author(s):  
Judith A. Ferry
Keyword(s):  
Follicular Lymphoma ◽  
Recent Advances

Detection of t(14;18)(q32;q21) in B-Cell Chronic Lymphocytic Leukemia

2005 ◽  
Vol 129 (3) ◽  
pp. 410-411
Author(s):  
Wolfgang Kern ◽  
Torsten Haferlach ◽  
Susanne Schnittger ◽  
Claudia Schoch
Keyword(s):  
Flow Cytometry ◽  
In Situ Hybridization ◽  
Chronic Lymphocytic Leukemia ◽  
Follicular Lymphoma ◽  
B Cell ◽  
Lymphocytic Leukemia ◽  
Multiparameter Flow Cytometry ◽  
Lymphoma Therapy ◽  
Cell Chronic Lymphocytic Leukemia

Abstract Cytomorphologic testing and multiparameter flow cytometry are the mainstays in diagnosing B-cell chronic lymphocytic leukemia, whereas fluorescence in situ hybridization that targets the translocation t(14;18)(q32;q21) often is used to identify follicular lymphoma. Therapy is highly diverse between both diseases. We describe a case with cytomorphologically and immunologically proven B-cell chronic lymphocytic leukemia in which t(14;18)(q32;q21) was found.

Recent advances in post-stretching processing of polymer films with in situ synchrotron radiation X-ray scattering

Soft Matter ◽  
2020 ◽  
Vol 16 (15) ◽  
pp. 3599-3612 ◽  
Author(s):  
Yuanfei Lin ◽  
Wei Chen ◽  
Lingpu Meng ◽  
Daoliang Wang ◽  
Liangbin Li
Keyword(s):  
Synchrotron Radiation ◽  
Polymer Films ◽  
X Ray ◽  
X Ray Scattering ◽  
Recent Advances ◽  
Ray Scattering

We review the recent advances in post-stretching processing of polymer films with in situ synchrotron radiation X-ray scattering.

Recent Advances of 1,3,5-Triazinanes in Aminomethylation and Cycloaddition Reactions

Synthesis ◽  
2020 ◽  
Vol 52 (17) ◽  
pp. 2469-2482
Author(s):  
Jia-Rong Chen ◽  
Dong Liang ◽  
Wen-Jing Xiao
Keyword(s):  
Reaction Mechanisms ◽  
Short Review ◽  
Cycloaddition Reactions ◽  
Recent Advances ◽  
Nitrogen Containing Compounds

1,3,5-Trisubstituted 1,3,5-triazinanes (hexahydro-1,3,5-triazines), as stable and readily available surrogates for formaldimines, have found extensive applications for the construction of various nitrogen-containing compounds. The formaldimines, formed in situ from this reagent class, can participate in various aminomethylation and cycloaddition­ reactions. This short review presents recent advances in this field with emphasis on the conceptual ideas behind the developed methodologies and the reaction mechanisms.1 Introduction2 Aminomethylations with 1,3,5-Triazinanes3 Cycloadditions with 1,3,5-Triazinanes3.1 Use of 1,3,5-Triazinanes as Two-Atom Synthons3.2 Use of 1,3,5-Triazinanes as Three-Atom Synthons3.3 Use of 1,3,5-Triazinanes as Four-Atom Synthons3.4 Use of 1,3,5-Triazinanes as Six-Atom Synthons4 Conclusions

scholarly journals Clonally related follicular lymphomas and histiocytic/dendritic cell sarcomas: evidence for transdifferentiation of the follicular lymphoma clone

Blood ◽  
2008 ◽  
Vol 111 (12) ◽  
pp. 5433-5439 ◽  
Author(s):  
Andrew L. Feldman ◽  
Daniel A. Arber ◽  
Stefania Pittaluga ◽  
Antonio Martinez ◽  
Jerome S. Burke ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Follicular Lymphoma ◽  
Chain Reaction ◽  
Interdigitating Cell ◽  
Clonal Origin ◽  
Polymerase Chain ◽  
Follicular Lymphomas ◽  
Bcl2 Gene ◽  
Interdigitating Cell Sarcoma

Abstract Rare cases of histiocytic and dendritic cell (H/DC) neoplasms have been reported in patients with follicular lymphoma (FL), but the biologic relationship between the 2 neoplasms is unknown. We studied 8 patients with both FL and H/DC neoplasms using immunohistochemistry, fluorescence in situ hybridization (FISH) for t(14;18), and polymerase chain reaction (PCR)/sequencing of BCL2 and IGH rearrangements. There were 5 men and 3 women (median age, 59 years). All cases of FL were positive for t(14;18). The H/DC tumors included 7 histiocytic sarcomas, 5 of which showed evidence of dendritic differentiation, and 1 interdigitating cell sarcoma. Five H/DC tumors were metachronous, following FL by 2 months to 12 years; tumors were synchronous in 3. All 8 H/DC tumors showed presence of the t(14;18) either by FISH, or in 2 cases by PCR with the major breakpoint region (MBR) probe. PCR and sequencing identified identical IGH gene rearrangements or BCL2 gene breakpoints in all patients tested. All H/DC tumors lacked PAX5, and up-regulation of CEBPβ and PU.1 was seen in all cases tested. These results provide evidence for a common clonal origin of FL and H/DC neoplasms when occurring in the same patient, and suggest that lineage plasticity may occur in mature lymphoid neoplasms.

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