Players of epithelial-to-mesenchymal transition (EMT) are expressed in the peri-tumoral stroma and in blood of pancreatic cancer patients.

Pancreatology ◽  
2014 ◽  
Vol 14 (3) ◽  
pp. S70
Author(s):  
Giuseppe Celesti ◽  
Andrea Gallioli ◽  
Matteo Tacelli ◽  
Francesca Gavazzi ◽  
Paola Spaggiari ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Patients ◽  
Epithelial To Mesenchymal Transition ◽  
Mesenchymal Transition

scholarly journals A crucial epithelial to mesenchymal transition regulator, Sox4/Ezh2 axis is closely related to the clinical outcome in pancreatic cancer patients

2015 ◽  
Vol 48 (1) ◽  
pp. 145-152 ◽  
Author(s):  
SHINICHIRO HASEGAWA ◽  
HIROAKI NAGANO ◽  
MASAMITSU KONNO ◽  
HIDETOSHI EGUCHI ◽  
AKIRA TOMOKUNI ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Clinical Outcome ◽  
Cancer Patients ◽  
Epithelial To Mesenchymal Transition ◽  
Mesenchymal Transition

scholarly journals Lessons to Learn for Adequate Targeted Therapy Development in Metastatic Colorectal Cancer Patients

2021 ◽  
Vol 22 (9) ◽  
pp. 5019
Author(s):  
Helena Oliveres ◽  
David Pesántez ◽  
Joan Maurel
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Cancer Patients ◽  
Tyrosine Kinases ◽  
Epithelial To Mesenchymal Transition ◽  
Acquired Resistance ◽  
Post Translational Modification ◽  
Mesenchymal Transition ◽  
Igf1r Signaling ◽  
Colorectal Cancer Patients

Insulin-like growth factor 1 receptor (IGF1R) is a receptor tyrosine kinase that regulates cell growth and proliferation. Upregulation of the IGF1R pathway constitutes a common paradigm shared with other receptor tyrosine kinases such as EGFR, HER2, and MET in different cancer types, including colon cancer. The main IGF1R signaling pathways are PI3K-AKT and MAPK-MEK. However, different processes, such as post-translational modification (SUMOylation), epithelial-to-mesenchymal transition (EMT), and microenvironment complexity, can also contribute to intrinsic and acquired resistance. Here, we discuss new strategies for adequate drug development in metastatic colorectal cancer patients.

scholarly journals CXCL12 and Its Isoforms: Different Roles in Pancreatic Cancer?

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Alessandra Righetti ◽  
Matteo Giulietti ◽  
Berina Šabanović ◽  
Giulia Occhipinti ◽  
Giovanni Principato ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Tumor Microenvironment ◽  
Stromal Cells ◽  
Tumor Invasion ◽  
Epithelial To Mesenchymal Transition ◽  
Current Knowledge ◽  
Tumor Development ◽  
Physiological Role ◽  
Mesenchymal Transition ◽  
Splicing Isoforms

CXCL12 is a chemokine that acts through CXCR4 and ACKR3 receptors and plays a physiological role in embryogenesis and haematopoiesis. It has an important role also in tumor development, since it is released by stromal cells of tumor microenvironment and alters the behavior of cancer cells. Many studies investigated the roles of CXCL12 in order to understand if it has an anti- or protumor role. In particular, it seems to promote tumor invasion, proliferation, angiogenesis, epithelial to mesenchymal transition (EMT), and metastasis in pancreatic cancer. Nevertheless, some evidence shows opposite functions; therefore research on CXCL12 is still ongoing. These discrepancies could be due to the presence of at least six CXCL12 splicing isoforms, each with different roles. Interestingly, three out of six variants have the highest levels of expression in the pancreas. Here, we report the current knowledge about the functions of this chemokine and then focus on pancreatic cancer. Moreover, we discuss the methods applied in recent studies in order to understand if they took into account the existence of the CXCL12 isoforms.

Glucose-Dependent FOXM1 Promotes Epithelial-to-Mesenchymal Transition Via Cellular Metabolism and Targeting Snail in Human Pancreatic Cancer

Pancreas ◽  
2020 ◽  
Vol 49 (2) ◽  
pp. 273-280
Author(s):  
Takuro Kyuno ◽  
Takayuki Kohno ◽  
Takumi Konno ◽  
Hiroshi Yamaguchi ◽  
Daisuke Kyuno ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Epithelial To Mesenchymal Transition ◽  
Cellular Metabolism ◽  
Human Pancreatic Cancer ◽  
Mesenchymal Transition

scholarly journals Exploration of Exosomal Micro RNA Biomarkers Related to Epithelial-to-Mesenchymal Transition in Pancreatic Cancer

2020 ◽  
Vol 40 (4) ◽  
pp. 1843-1853 ◽  
Author(s):  
FUMINORI SONOHARA ◽  
SUGURU YAMADA ◽  
SHIGEOMI TAKEDA ◽  
MASAMICHI HAYASHI ◽  
MASAYA SUENAGA ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Epithelial To Mesenchymal Transition ◽  
Micro Rna ◽  
Mesenchymal Transition ◽  
Rna Biomarkers
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