scholarly journals Exploration of Exosomal Micro RNA Biomarkers Related to Epithelial-to-Mesenchymal Transition in Pancreatic Cancer

2020 ◽  
Vol 40 (4) ◽  
pp. 1843-1853 ◽  
Author(s):  
FUMINORI SONOHARA ◽  
SUGURU YAMADA ◽  
SHIGEOMI TAKEDA ◽  
MASAMICHI HAYASHI ◽  
MASAYA SUENAGA ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Epithelial To Mesenchymal Transition ◽  
Micro Rna ◽  
Mesenchymal Transition ◽  
Rna Biomarkers

scholarly journals CXCL12 and Its Isoforms: Different Roles in Pancreatic Cancer?

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Alessandra Righetti ◽  
Matteo Giulietti ◽  
Berina Šabanović ◽  
Giulia Occhipinti ◽  
Giovanni Principato ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Tumor Microenvironment ◽  
Stromal Cells ◽  
Tumor Invasion ◽  
Epithelial To Mesenchymal Transition ◽  
Current Knowledge ◽  
Tumor Development ◽  
Physiological Role ◽  
Mesenchymal Transition ◽  
Splicing Isoforms

CXCL12 is a chemokine that acts through CXCR4 and ACKR3 receptors and plays a physiological role in embryogenesis and haematopoiesis. It has an important role also in tumor development, since it is released by stromal cells of tumor microenvironment and alters the behavior of cancer cells. Many studies investigated the roles of CXCL12 in order to understand if it has an anti- or protumor role. In particular, it seems to promote tumor invasion, proliferation, angiogenesis, epithelial to mesenchymal transition (EMT), and metastasis in pancreatic cancer. Nevertheless, some evidence shows opposite functions; therefore research on CXCL12 is still ongoing. These discrepancies could be due to the presence of at least six CXCL12 splicing isoforms, each with different roles. Interestingly, three out of six variants have the highest levels of expression in the pancreas. Here, we report the current knowledge about the functions of this chemokine and then focus on pancreatic cancer. Moreover, we discuss the methods applied in recent studies in order to understand if they took into account the existence of the CXCL12 isoforms.

Glucose-Dependent FOXM1 Promotes Epithelial-to-Mesenchymal Transition Via Cellular Metabolism and Targeting Snail in Human Pancreatic Cancer

Pancreas ◽  
2020 ◽  
Vol 49 (2) ◽  
pp. 273-280
Author(s):  
Takuro Kyuno ◽  
Takayuki Kohno ◽  
Takumi Konno ◽  
Hiroshi Yamaguchi ◽  
Daisuke Kyuno ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Epithelial To Mesenchymal Transition ◽  
Cellular Metabolism ◽  
Human Pancreatic Cancer ◽  
Mesenchymal Transition

Abstract 458: Implication of epithelial to mesenchymal transition (EMT) in pancreatic cancer prognosis

2012 ◽  
Author(s):  
Suguru Yamada ◽  
Tsutomu Fujii ◽  
Bryan C. Fuchs ◽  
Hiroyuki Sugimoto ◽  
Shuji Nomoto ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Epithelial To Mesenchymal Transition ◽  
Cancer Prognosis ◽  
Mesenchymal Transition
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