scholarly journals OVEREXPRESSION OF TWIST AND REDUCED E-CADHERIN EXPRESSION ARE ASSOCIATED WITH POOR BIOLOGICAL BEHAVIOR IN LOWER LIP SQUAMOUS CELL CARCINOMA: AN IMMUNOHISTOCHEMICAL STUDY

2019 ◽  
Vol 128 (1) ◽  
pp. e73
Author(s):  
Ms. Hellen Santos ◽  
Mr. Everton Morais ◽  
Prof. Jean Nunes Dos Santos ◽  
Prof. HÉbel Cavalcanti GalvÃo ◽  
Dr. LÉlia Batista de Souza ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Immunohistochemical Study ◽  
Biological Behavior ◽  
Lower Lip ◽  
E Cadherin

Multinucleated giant cell reaction in lower lip squamous cell carcinoma: a clinical, morphological, and immunohistochemical study

2017 ◽  
Vol 46 (9) ◽  
pp. 773-779 ◽  
Author(s):  
Hellen Bandeira de Pontes Santos ◽  
Márcia Cristina da Costa Miguel ◽  
Leão Pereira Pinto ◽  
Manuel Antonio Gordón-Núñez ◽  
Pollianna Muniz Alves ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Giant Cell ◽  
Squamous Cell ◽  
Multinucleated Giant Cell ◽  
Immunohistochemical Study ◽  
Cell Reaction ◽  
Lower Lip

scholarly journals Immunoexpression of P16 and Ki 67 in oral squamous cell carcinoma: Association with clinicopathological parameters.

2020 ◽  
Vol 3 (2) ◽  
pp. 135-144
Author(s):  
Shadan Omer ◽  
Payman Rashid
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Biological Behavior ◽  
Clinicopathological Parameters ◽  
Statistical Association ◽  
Ki 67 ◽  
Lower Lip ◽  
Significant Statistical Association

Background and Objectives: Oral squamous cell carcinoma (OSCC) is considered as a major health problem worldwide and has been associated with high recurrence rate and poor progno-sis. Advances in understanding of OSCC have not improved the outcome in their management significantly. Many studies have focused on the roles of biomolecular markers in OSCC. The use of p16 and Ki67 as biomarkers of biological behavior of oral squamous cell carcinoma is contro-versial. This study aimed to determine immunoexpression of P16 and Ki67 in oral squamous cell carcinoma and to evaluate their association with various clinicopathological parameters. Materials and Methods: Fifty cases of squamous cell carcinoma from different locations in the oral cavity were included in this cross sectional study. The cases were collected from Rizgary Teaching Hospital and Private Laboratories in Erbil city during a period of eight months from October 2018 to May 2019. The expression of p16 and Ki 67 were evaluated immunohistochem-ically; the findings were correlated with the age of the patients, gender, site of the tumor and grade of the tumor. Result: A total of 50 patients with oral squamous cell carcinoma were enrolled in this study the age ranged from 33 to 89 years, with a mean age ± SD of (64.24 ±12.01) years and more than half (52.0%) of them were males. Lower lip was the most common site of the tumor followed by upper lip and tongue (42.0%, 26.0% and 18.0%, respectively). Histopathological findings of the tumor showed that (54.0%) of the patients had moderately differentiated squamous cell carci-noma. However, (84.0%) of the patients showed negative expression of P 16, while Ki 67 ex-pression was positive among (76.0%) of them. No significant statistical association were found between immunoexpression of p16 and age, sex of patient, site of the tumor and grade of the tumor (P=0.67, P=0,095, P=0.696, P=0.454 respectively). No significant statistical association were found between immunoexpression of Ki67 and age, sex of patient, site of the tumor and grade of the tumor (P=0.637, P=0,411, P=0.353, P=1.00 respectively). Conclusion: in relation to the results obtained in this study no significant association were found between P16 and Ki 67 immunoexpression in oral squamous cell carcinoma with clinicopatho-logical parameters. Further researches have to be designed to better understand the role of p16 and Ki 67 in OSCC. Keywords: oral squamous cell carcinoma, immunoexpression, P16, Ki67.

An Immunohistochemical Study of E-Cadherin Expression in Human Squamous Cell Carcinoma of the Skin

1999 ◽  
Vol 26 (7) ◽  
pp. 416-422 ◽  
Author(s):  
Shin Koseki ◽  
Takehiko Aoki ◽  
Shinichi Ansai ◽  
Yutaka Hozumi ◽  
Yoshihiko Mitsuhashi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Immunohistochemical Study ◽  
Human Squamous Cell Carcinoma ◽  
E Cadherin

scholarly journals Role of E-cadherin in Progression of Oral Squamous Cell Carcinoma: A Retrospective Immunohistochemical Study

2018 ◽  
Vol 19 (9) ◽  
pp. 1105-1110 ◽  
Author(s):  
Seema Sharma ◽  
Awadhesh Gupta ◽  
Mohammed Abidullah ◽  
Swathi Bhuvinder ◽  
Padmavathi Katragadda
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Immunohistochemical Study ◽  
E Cadherin

Twist and E-cadherin deregulation might predict poor prognosis in lower lip squamous cell carcinoma

2019 ◽  
Vol 127 (4) ◽  
pp. 318-329 ◽  
Author(s):  
Everton Freitas de Morais ◽  
Hellen Bandeira de Pontes Santos ◽  
Israel Leal Cavalcante ◽  
Silvia Helena Barem Rabenhorst ◽  
Jean Nunes dos Santos ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Poor Prognosis ◽  
Lower Lip ◽  
E Cadherin

TWIST AND E-CADHERIN EXPRESSION IN LOWER-LIP SQUAMOUS CELL CARCINOMA

2020 ◽  
Vol 129 (1) ◽  
pp. e145
Author(s):  
RANI IANI COSTA GONÇALO ◽  
EVERTON FREITAS DE MORAIS ◽  
HELLEN BANDEIRA DE PONTES SANTOS ◽  
DEBORAH GONDIM LAMBERT MOREIRA ◽  
JEAN NUNES DOS SANTOS ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lower Lip ◽  
E Cadherin
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