NRF2-PEROXIREDOXIN I AXIS IS ASSOCIATED WITH DOWN-REGULATION OF MATRIX METALLOPROTEINASE 2 IN POLYMORPHOUS LOW-GRADE ADENOCARCINOMA

2017 ◽  
Vol 124 (3) ◽  
pp. e213
Author(s):  
N. NAVARINI ◽  
J. BROD ◽  
A. DEMASI ◽  
V. MONTALLI ◽  
L. TEIXEIRA ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 2 ◽  
Low Grade ◽  
Down Regulation ◽  
Peroxiredoxin I

scholarly journals Differential Expression of Matrix Metalloproteinase-2 Expression in Disseminated Tumor Cells and Micrometastasis in Bone Marrow of Patients with Nonmetastatic and Metastatic Prostate Cancer: Theoretical Considerations and Clinical Implications—An Immunocytochemical Study

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Nigel P. Murray ◽  
Eduardo Reyes ◽  
Pablo Tapia ◽  
Leonardo Badínez ◽  
Nelson Orellana
Keyword(s):  
Prostate Cancer ◽  
Bone Marrow ◽  
Matrix Metalloproteinase ◽  
Tumor Cells ◽  
Gleason Score ◽  
Stromal Cells ◽  
Disseminated Tumor Cells ◽  
Matrix Metalloproteinase 2 ◽  
Low Grade ◽  
Immunocytochemical Study

Matrix metalloproteinase-2 (MMP-2) is important in the dissemination and invasion of tumor cells and activates angiogenesis. We present an immunocytochemical study of MMP-2 expression in circulating prostate cells (CPCs), disseminated tumor cells (DTCs), and micrometastasis (mM) in bone marrow of men with prostate cancer. Methods and Patients. Tumor cells were identified with anti-PSA immunocytochemistry. Positive samples underwent processing with anti-MMP-2, its expression was compared with Gleason score, concordance of expression, and metastatic and nonmetastatic disease. Results. 215 men participated, CPCs were detected in 62.7%, DTCs in 62.2%, and mM in 71.4% in nonmetastatic cancer; in metastatic cancer all had CPCs, DTCs, and mM detected. All CPCs and DTCs expressed MMP-2; in mM MMP-2 expression was positively associated with increasing Gleason score. MMP-2 expression in CPCs and DTCs showed concordance. In low grade tumors, mM and surrounding stromal cells were MMP-2 negative, with variable expression in high grade tumors; in metastatic disease, both mM and stromal cells were MMP-2 positive. Conclusions. CPCs and DTCs are different from mM, with inhibition of MMP-2 expression in mM of low grade tumors. With disease progression, MMP-2 expression increases in both mM and surrounding stromal cells, with implications for the use of bisphosphonates or MMP-2 inhibitors.

scholarly journals Down-regulation of glomerular matrix metalloproteinase-2 gene in human NIDDM

Diabetologia ◽  
1997 ◽  
Vol 40 (12) ◽  
pp. 1449-1454 ◽  
Author(s):  
D. Del Prete ◽  
F. Anglani ◽  
M. Forino ◽  
M. Ceol ◽  
P. Fioretto ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 2 ◽  
Down Regulation

scholarly journals Nrf2-peroxiredoxin I axis in polymorphous adenocarcinoma is associated with low matrix metalloproteinase 2 level

2017 ◽  
Vol 471 (6) ◽  
pp. 793-798 ◽  
Author(s):  
J. M. Brod ◽  
Ana Paula Dias Demasi ◽  
V. A. Montalli ◽  
L. N. Teixeira ◽  
C. Furuse ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 2 ◽  
Polymorphous Adenocarcinoma ◽  
Peroxiredoxin I

scholarly journals The matrix metalloproteinase 2 (MMP2) is differentially expressed and down-regulated in metastases to the lymph node and the brain in patients with metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Matrix Metalloproteinase ◽  
Lymph Nodes ◽  
Metastatic Breast ◽  
Metastatic Tumor ◽  
Matrix Metalloproteinase 2 ◽  
Down Regulation ◽  
The Matrix ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes to discover genes associated with brain metastasis in patients with metastatic breast cancer. We found that the matrix metalloproteinase 2, MMP2 was among the genes whose expression was most different in the metastatic tumor tissues of patients with metastatic breast cancer, both in metastases to brain and to the lymph nodes when compared to primary tumors of the breast or normal breast tissue, respectively. We observed significant down-regulation of MMP2 in metastasis to the brain and in metastasis to the lymph nodes. Molecular functions and down-regulation of MMP2 may be important for metastasis of primary tumor-derived cancer cells to the lymph nodes and to the brain in humans with metastatic breast cancer and these data combined suggest some level of common origin for metastases that reside in the lymph nodes and colonize the brain.

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