scholarly journals Down-regulation of glomerular matrix metalloproteinase-2 gene in human NIDDM

Diabetologia ◽  
1997 ◽  
Vol 40 (12) ◽  
pp. 1449-1454 ◽  
Author(s):  
D. Del Prete ◽  
F. Anglani ◽  
M. Forino ◽  
M. Ceol ◽  
P. Fioretto ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 2 ◽  
Down Regulation

scholarly journals The matrix metalloproteinase 2 (MMP2) is differentially expressed and down-regulated in metastases to the lymph node and the brain in patients with metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Matrix Metalloproteinase ◽  
Lymph Nodes ◽  
Metastatic Breast ◽  
Metastatic Tumor ◽  
Matrix Metalloproteinase 2 ◽  
Down Regulation ◽  
The Matrix ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes to discover genes associated with brain metastasis in patients with metastatic breast cancer. We found that the matrix metalloproteinase 2, MMP2 was among the genes whose expression was most different in the metastatic tumor tissues of patients with metastatic breast cancer, both in metastases to brain and to the lymph nodes when compared to primary tumors of the breast or normal breast tissue, respectively. We observed significant down-regulation of MMP2 in metastasis to the brain and in metastasis to the lymph nodes. Molecular functions and down-regulation of MMP2 may be important for metastasis of primary tumor-derived cancer cells to the lymph nodes and to the brain in humans with metastatic breast cancer and these data combined suggest some level of common origin for metastases that reside in the lymph nodes and colonize the brain.

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