The role of perineural invasion on head and neck adenoid cystic carcinoma prognosis: a systematic review and meta-analysis

2016 ◽  
Vol 122 (6) ◽  
pp. 691-701 ◽  
Author(s):  
Jun Ju ◽  
Yun Li ◽  
Juan Chai ◽  
Chao Ma ◽  
Qianwei Ni ◽  
...  
Keyword(s):  
Systematic Review ◽  
Adenoid Cystic Carcinoma ◽  
Head And Neck ◽  
Perineural Invasion ◽  
Meta Analysis ◽  
Adenoid Cystic

scholarly journals Prognostic importance of the lymphovascular invasion in head and neck adenoid cystic carcinoma: A systematic review and meta-analysis

Oral Oncology ◽  
2019 ◽  
Vol 93 ◽  
pp. 52-58 ◽  
Author(s):  
Bárbara Martins-Andrade ◽  
Sara Ferreira dos Santos Costa ◽  
Maria Sissa Pereira Sant'ana ◽  
Albina Altemani ◽  
Pablo Agustin Vargas ◽  
...  
Keyword(s):  
Systematic Review ◽  
Adenoid Cystic Carcinoma ◽  
Head And Neck ◽  
Lymphovascular Invasion ◽  
Meta Analysis ◽  
Adenoid Cystic ◽  
Prognostic Importance

t(6;9)(MYB‐NFIB) in head and neck adenoid cystic carcinoma: A systematic review with meta‐analysis

Oral Diseases ◽  
2019 ◽  
Vol 25 (5) ◽  
pp. 1277-1282 ◽  
Author(s):  
Yasmin Dias Almeida‐Pinto ◽  
Sara Ferreira dos Santos Costa ◽  
Bruno Augusto Benevenuto Andrade ◽  
Albina Altemani ◽  
Pablo Agustin Vargas ◽  
...  
Keyword(s):  
Systematic Review ◽  
Adenoid Cystic Carcinoma ◽  
Head And Neck ◽  
Meta Analysis ◽  
Adenoid Cystic

scholarly journals Clinicopathological Features of Adenoid Cystic Carcinoma: An Institutional Perspective

2020 ◽  
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Head And Neck ◽  
Perineural Invasion ◽  
Neck Region ◽  
The Body ◽  
Clinicopathologic Features ◽  
Head And Neck Region ◽  
Adenoid Cystic ◽  
Significant Difference ◽  
Histologic Pattern

Introduction: Adenoid cystic carcinoma is a rare salivary gland malignancy that can occur in any part of the body, its clinicopathologic features are scarcely reported in locoregional literature. Therefore, in this study we aimed to evaluate the clinicopathologic features of adenoid cystic carcinoma in our population and to determine the association of age and site of its occurrence with histologic pattern and perineural invasion. Methods: We retrospectively analyzed 30 cases of adenoid cystic carcinoma that underwent surgical resections or biopsies from March 2009 to February 2020 at Liaquat National Hospital and Medical College, Karachi. Clinical and histopathological parameters including age, site, histological pattern and perineural invasion were determined and association between different parameters was analyzed. Results: Mean age of the patients was 30 + 16.1 years. Cribriform pattern was most common histologic pattern (63.3%) while head and neck region was the most common site of occurrence (83.3%). Perineural invasion which is one of the most important prognostic factors in adenoid cystic carcinoma was present in approximately half of the patients (46.7%). No significant association of age and site was found with histologic pattern and perineural invasion. Conclusion: Adenoid cystic carcinoma is a rare malignancy most commonly occurring in head and neck region with a high frequency of perineural invasion. No significant difference of histologic pattern and histologic prognostic parameter like perineural invasion was noted at different ages and different sites in our study.

scholarly journals Circulating MicroRNAs as Prognostic Molecular Biomarkers in Human Head and Neck Cancer: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Shree Ram Lamichhane ◽  
Thanuja Thachil ◽  
Harriet Gee ◽  
Natalie Milic
Keyword(s):  
Systematic Review ◽  
Overall Survival ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Meta Analysis ◽  
Prognostic Role ◽  
Circulating Micrornas

Background. Circulating microRNAs (miRNAs) are potential molecular biomarkers for cancer detection; however, little is known about their prognostic role in head and neck cancer. This current study is aimed at evaluating the role of novel miRNAs in the survival of head and neck cancer patients. Materials and Methods. We performed a systematic literature search using online databases for articles published between December 2006 and February 2019. A meta-analysis was conducted to assess the correlation between miRNA expressions and overall survival (OS) among the selected head and neck cancer studies. After multilevel screening by reviewers, meta-analysis was performed using hazard ratios (HR) and associated 95% confidence interval (CI) of survival to calculate a pooled effect size. Result. A total of 1577 patients across 13 studies were included in the literature review, with 18 miRNAs upregulated and 4 miRNAs downregulated predicting a poor overall survival. The forest plot generated using cumulated survival data resulted in a pooled HR value of 2.943 (95% CI: 2.394-3.618) indicating a strong association of dysregulated miRNA expression with a poor outcome. Only 2 miRNAs—low levels of miR-9 and high levels of miR-483-5p—were observed in two studies, both showing a significant association with overall cancer survival. Conclusion. To our knowledge, this is the first comprehensive systematic review and meta-analysis that examines the prognostic role of circulating miRNAs from blood in head and neck cancer patients. The combined effect estimates a HR across multiple studies and also supports the previous individual findings that an alteration in miRNA expression is highly associated with poor prognosis. This has the potential to use serum and/or plasma miRNAs as biomarkers and become novel tools for predicting the prognosis of head and neck cancer patients in the near future.

scholarly journals The role of perineural invasion in penile cancer: a meta-analysis and systematic review

2018 ◽  
Vol 38 (5) ◽  
Author(s):  
Xiang Zhou ◽  
Feng Qi ◽  
Ruhua Zhou ◽  
Shangqian Wang ◽  
Yamin Wang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Penile Cancer ◽  
Perineural Invasion ◽  
Meta Analysis ◽  
Oncologic Outcome ◽  
Cancer Specific Survival ◽  
Significant Difference ◽  
Predictive Role ◽  
The Difference

The significance of perineural invasion (PNI) present in penile cancer (PC) is controversial. In order to clarify the predictive role of PNI in the inguinal lymph node (ILN) metastases (ILNM) and oncologic outcome of patients, we performed this meta-analysis and systematic review. The search of PubMed, Embase, and Web of Science was conducted for appropriate studies, up to 20 January 2018. The pooled odds ratio (OR) and hazard ratio (HR) with their 95% confidence interval (CI) were applied to evaluate the difference in ILNM and oncologic outcome between patients present with PNI and those who were absent. A total of 298 in 1001 patients present with PNI were identified in current meta-analysis and systematic review. Significant difference was observed in ILNM between PNI present and absent from patients with PC (OR = 2.98, 95% CI = 2.00–4.45). Patients present with PNI had a worse cancer-specific survival (CSS) (HR = 3.58, 95% CI = 1.70–7.55) and a higher cancer-specific mortality (CSM) (HR = 2.20, 95% CI = 1.06–3.82) than those cases without PNI. This meta-analysis and systematic review demonstrated the predictive role of PNI in ILNM, CSS, and CSM for PC patients.

Distinct microscopic features of perineural invasion in adenoid cystic carcinoma of the head and neck

2013 ◽  
Vol 64 (7) ◽  
pp. 1037-1039 ◽  
Author(s):  
Afshin Teymoortash ◽  
Lara Zieger ◽  
Stephan Hoch ◽  
Axel Pagenstecher ◽  
Markus J Hofer
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Head And Neck ◽  
Perineural Invasion ◽  
Adenoid Cystic ◽  
Microscopic Features

scholarly journals Clinicopathological characteristics and perineural invasion in adenoid cystic carcinoma: a systematic review

2015 ◽  
Vol 81 (3) ◽  
pp. 329-335 ◽  
Author(s):  
Afonso Nóbrega Dantas ◽  
Everton Freitas de Morais ◽  
Rômulo Augusto de Paiva Macedo ◽  
João Maria de Lima Tinôco ◽  
Maria de Lourdes Silva de Arruda Morais
Keyword(s):  
Systematic Review ◽  
Adenoid Cystic Carcinoma ◽  
Perineural Invasion ◽  
Clinicopathological Characteristics ◽  
Adenoid Cystic
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