Prevalence of Human Papillomavirus in Malignant Lesions of the Oral Cavity and its Association With Risk Factors for Oral Cancer

2015 ◽  
Vol 120 (2) ◽  
pp. e102
Author(s):  
KAMILE LEONARDI DUTRA ◽  
BRUNO EDUARDO SILVA DE ARAUJO ◽  
MARIA LUIZA BAZZO ◽  
ELENA RIET CORREA RIVERO ◽  
ALEXANDRE SHERLLEY CASIMIRO ONOFRE
Keyword(s):  
Risk Factors ◽  
Human Papillomavirus ◽  
Oral Cancer ◽  
Oral Cavity ◽  
Malignant Lesions

scholarly journals Smoking, alcohol consumption and human papillomavirus infection as risk factors for oral cavity and oropharyngeal tumors in Serbia - a pilot study

2020 ◽  
Vol 77 (7) ◽  
pp. 740-745
Author(s):  
Ljiljana Bozic ◽  
Predrag Jeremic ◽  
Milovan Dimitrijevic ◽  
Tanja Jovanovic ◽  
Aleksandra Knezevic
Keyword(s):  
Risk Factors ◽  
Human Papillomavirus ◽  
High Risk ◽  
Alcohol Consumption ◽  
Oral Cavity ◽  
Tongue Cancer ◽  
Hpv Infection ◽  
Benign Lesions ◽  
Significant Difference ◽  
Malignant Lesions

Background/Aim. The oral cavity and oropharyngeal cancers are among the most common cancers worldwide with the multifactorial etiology. The aim of this study was to determine the major risk factors among patients with oral cavity and oropharyngeal tumors in Serbia. Methods. A total of 63 patients with biopsy proven malignant (33 patients) or benign (30 patients) oral cavity or oropharyngeal lesions were included in this study. The data about gender, age, smoking habits and alcohol consumption were obtained from the routine medical files. The detection and genotyping of human papillomavirus (HPV) was done in paraffin embedded tissue samples using in situ hybridization. Results. Malignant lesions were more frequent in men, smokers and patients who consume alcohol with a statistically significant difference compared to the patients with benign lesions. The prevalence of HPV infection was higher in patients with malignant lesions compared to patients with benign lesions, but without statistically significant difference. High risk genotypes were detected only in patients with malignant lesions of tonsils and base tongue cancer, while low risk types were demonstrated in patients with benign lesions with a highly statistically significant difference. Conclusion. The results point to the significant association of tobacco smoking, alcohol consumption and high risk HPV genotypes as risk factors for oral cavity and oropharyngeal carcinomas in Serbian patients.

Human Papillomavirus in Various Lesions of the Head and Neck

1985 ◽  
Vol 93 (3) ◽  
pp. 342-346 ◽  
Author(s):  
Melvin Strauss ◽  
A. Bennett Jenson
Keyword(s):  
Human Papillomavirus ◽  
Oral Cavity ◽  
Head And Neck ◽  
Adult Onset ◽  
Childhood Onset ◽  
Oncogenic Potential ◽  
Suggestive Evidence ◽  
Malignant Lesions ◽  
Epithelial Lesions

The association of human papillomavirus with benign and malignant epithelial lesions of the head and neck has been studied by a peroxidase-antiperoxidase technique having immunospecificity against genus-specific structural antigens of the papillomaviruses. More than 360 specimen blocks from 144 patients were evaluated. There was evidence of human papillomavirus antigen in three out of eight patients with childhood-onset laryngeal papillomas (37.5%) and in four out of eight patients with adult-onset papillomas (50%). A patient with an unusual flat, wartlike lesion appearing as an oral cavity leukoplakia had detectable papillomavirus antigen in it. None of the 13 cases of inverting papilloma or any of the malignant lesions studied showed evidence for the presence of papillomavirus antigen. There is currently only suggestive evidence for the oncogenic potential of human papillomavirus in the head and neck.

scholarly journals Detection of human papilloma virus in potentially malignant and malignant lesions of the oral cavity and a study of associated risk factors

2016 ◽  
Vol 05 (04) ◽  
pp. 179-181 ◽  
Author(s):  
B. R. Bijina ◽  
Junaid Ahmed ◽  
Nandita Shenoy ◽  
Ravikiran Ongole ◽  
Suchitra Shenoy ◽  
...  
Keyword(s):  
Risk Factors ◽  
Oral Cavity ◽  
Squamous Cell ◽  
Chi Square ◽  
Potentially Malignant ◽  
Chi Square Test ◽  
Malignant Lesions ◽  
Well Differentiated ◽  
Associated Risk Factors ◽  
Histopathological Grading

Abstract Background: Squamous cell carcinoma of the head and neck is the 6 th most frequently occurring cancer worldwide, with over 400,000 cases projected annually. Multiple factors such as tobacco, alcohol, irradiation, virus, and chronic irritants are involved in the development of oral squamous cell carcinomas (OSCCs). The most important risk factors are chronic exposure to tobacco and alcohol. Although the evidence that implicates virus is increasing, particularly (human papillomavirus [HPV]), in the carcinogenesis process, the role of virus is not well established. Aim and Objective: This study is designed to assess the presence of HPV in potentially malignant and malignant lesions of the oral cavity as well as to correlate the presence of HPV with addictive habits and histopathological grading of the disease. Materials and Methods: Biopsy samples of OSCC and potentially malignant lesions were obtained and 3, 5 μm thickness sections were cut using a microtome. The sections were collected using a sterile brush and transferred to an Eppendorf tube. DNA extraction and polymerase chain reaction for the detection of HPV were done. Results and Conclusion: The association between histopathological grading and presence of HPV was assessed using Chi-square test and the values thus obtained were found to be statistically significant. HPV was more predominantly seen in well-differentiated carcinomas and moderately differentiated carcinomas as compared to poorly differentiated carcinomas.

scholarly journals Expression OF p16INK4a Gene in Premalignant and Malignant Lesions of Oral Cavity

2021 ◽  
pp. 53-62
Author(s):  
R. Vijay David Raj ◽  
S. Marylilly
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Malignant Lesion ◽  
Malignant Neoplasm ◽  
Premalignant Lesions ◽  
Group I ◽  
Malignant Lesions

Squamous cell carcinoma is the summits malignant neoplasm of the oral cavity. Tobacco and alcohol is identified as risk factors, but squamous cell carcinoma can occur in patients with no known risk factors. Oral cancer is the sixth most common malignancy and is one of the major causes of cancer morbidity and mortality worldwide. Cancer is caused due to a series of alteration in genetic and epigenetic factors that occur in multiple steps and is influenced by the genetic predisposition of the individual and by exogenous environmental factors. These factors result in a series of molecular alteration, including inactivation of tumor suppressor genes expression of p16 has been proposed as a marker for malignant transformation. The p16 staining was correlated between the control and study groups and p 16 was shown to be increasing expressed in premalignant and less expressed in malignant category and was found to be statistically significant by Fischer’s exact test. This study concluded that p16 was increasingly expressed in premalignant lesions and less expressed in malignant lesion. In the present study 9 of the control cases were p16 negative and one case showed sporadic staining. The study group I showed 1 case of sporadic staining, 6 cases of focal staining and 8 cases of diffuse staining. The study II showed 14 cases of sporadic staining, 6 cases of focal staining and 5 cases of diffuse staining. Hence variations cannot be accurately assessed, but it plays a crucial role in assessing pre-malignant lesions progressing to malignancy. To confirm this, a larger sample study is required. As advances in research have leads to greater understanding of potentially malignant lesions in the oral cavity.

Risk Factors and the Mechanism of Induced Oral Cancer by the Chemical Substances

2018 ◽  
Vol 69 (5) ◽  
pp. 1283-1287
Author(s):  
Ovidiu Mihail Stefanescu ◽  
Raluca Dragomir ◽  
Oanaelena Ciurcanu ◽  
Cristian Constantin Budacu
Keyword(s):  
Risk Factors ◽  
Oral Cancer ◽  
Oral Cavity ◽  
Combined Therapy ◽  
Considerable Change ◽  
Component Structure ◽  
Sex Risk ◽  
Tumor Group ◽  
Molar Teeth ◽  
Tumor Extirpation

At this end of the millennium we witness an impressive increase in cancer frequency. According to WHO reports, cancer is the second cause of death, being overpriced by cardiovascular disease only. The oral cavity cancer is part of the ENT sphere malignant tumor group. It may appear at the level of any component structure: mobile tongue, mouth floor, retromolar trine (behind the last molar teeth in the lower arch), tough palate, internal cheek, lips, mouth vestibule or alveolar rebord. Salivary glands, although opening into the oral cavity, can not be included in this category, due to histological and enlargement features. Oral cancer is very easy to be noted because it causes a mouthstroke that does not heal over several weeks. This is the main symptom of the disease, but not the only one. Other signs are: whitish spots in the mouth, unexplained bleeding, difficulty in moving the jaw or chewing; hoarseness or considerable change in voice, loss of sensation or pain in the mouth, face or neck area, undue ear pain. The study includes 544 cases, and the statistical data collected over a 5-year period, 2013-2017, and: age, environment, sex, risk factors involved, location, tumor study and treatment are of interest. Combined therapy was reserved for patients with a low healing rate. The most common form of treatment was tumor removal within the limits of tumor safety, followed by another type of intervention: tumor extirpation and ganglion recording, whether or not associated with radiotherapy. An important role is also played by patients who come late, either due to a lack of health education or because of the fear of illness, or in most cases due to the oligosymptomatic character of the disease at the onset of onset.

scholarly journals An insight into risk factors profile of oral cavity and oropharyngeal cancer patients attending two tertiary care hospitals in Jaipur, India

2019 ◽  
Vol 8 (2) ◽  
pp. 275
Author(s):  
Kopal Sharma ◽  
Lokendra Sharma ◽  
Uma Advani ◽  
Charu Jain ◽  
Alka Bansal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Oral Cancer ◽  
Oral Cavity ◽  
Cancer Patients ◽  
Oropharyngeal Cancer ◽  
Tertiary Care ◽  
Age Groups ◽  
Clinical Information ◽  
Males And Females ◽  
Clinical Records

Background: Oral cancer is the second most prevalent cancers among males in Jaipur city. Assessment of risk factors profile of patients will help the policy makers in initiating new ways to curb the usage of tobacco among masses. The present study aims to find out the risk factors profile of oral and oropharyngeal cancer patients at two hospitals of Jaipur city.Methods: It was a prospective and observational study. The patients with histologically confirmed diagnosis of oral cavity and oropharyngeal cancers and fulfilling the inclusion criteria were recruited. Data on the demographic profile and clinical information were obtained from hospital and clinical records. The data were analyzed using SPSS version 14 (SPSS Inc., Chicago, IL, USA). Chi-square test was performed to analyse the data.Results: Out of 400 oral cancer patients included in this study majority of the patients were in the age range of 40-60years and with a significant male preponderance in all the age groups (P <0.05). The most common habit among males and females was chewing. Buccal mucosa was the most commonly affected site followed by tongue. Both males and females were more likely to be diagnosed in stage 3 (p <0.05).Conclusions: There is a need to reduce the burden of this disease by educating the people about various risk factors which play role in oral cancer development.

scholarly journals Knowledge Assessment among the Fourth and Fifth Year Students on the Potentially Malignant Lesions of Oral Cavity

2020 ◽  
Vol 24 (1) ◽  
pp. 14-20
Author(s):  
Sanja Hadžić ◽  
Mirjana Gojkov-Vukelić ◽  
Enes Pašić ◽  
Arma Muharemović ◽  
Indira Mujić Jahić
Keyword(s):  
Oral Cancer ◽  
Oral Cavity ◽  
Oral Mucosa ◽  
Cross Sectional Study ◽  
Self Assessment ◽  
Cross Sectional ◽  
Increased Risk ◽  
Potentially Malignant ◽  
Malignant Lesions ◽  
The Difference

SummaryBackground/Aim: Potentially malignant oral lesions (PMOL) are lesions that have an increased risk of malignant transformation concerning healthy oral mucosa. This research aimed to assess the knowledge of students of final years of study on the potentially malignant lesions of the oral cavity.Material and Methods: 120 students of the fourth and fifth years of study participated in this research,60 respondents were fourth-year students, 60 respondents were fifth-year students. All of the respondents signed informed consent.According to the type of research, this is a cross-sectional study which was conducted by completing a 15-item questionnaire. The results were statistically analyzed and processed in the SPSS Statistics 21.0 program.Results: The results indicate that during the clinical examination the fourth and fifth-year students examine the oral mucosa as well. 61% of the students find themselves poorly informed on the PMOL. In the fourth year of study, only 5,5% of students responded that they were well informed, while in the fifth year that number totaled 28,5%. When knowledge self-assessment is concerned the difference has shown itself to be statistically significant between the fourth and fifth-year students. When asked what knowledge on the prevention of oral cancer they expect to receive during their studies, 78% of the students expected more knowledge than at that moment – 36% of which were fifth-year students, and 42% were fourth-year students.Conclusions: Even though the oral cavity is easily accessible to examination, the discovery of oral cancer occurs quite late. Ours, as well as results of other studies, impose the need for better theoretical and practical education of the students.

Primary squamous cell carcinoma of the oral cavity at presentation in Pakistan

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e17002-e17002
Author(s):  
A. Jamshed ◽  
R. Hussain ◽  
K. Rehman ◽  
H. Iqbal ◽  
S. Hameed ◽  
...  
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Alcohol Use ◽  
Oral Cancer ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
World Health ◽  
Betel Quid ◽  
Betel Quid Chewing

e17002 Background: Squamous cell carcinoma of oral cavity (SCCOC) is characterized by marked geographical differences in frequency and site distribution. Pakistan is situated within the high risk zone on the global oral cancer map. However, no reliable data exists on oral cancer in this area. Our aim was to determine clinicopathological features and patterns at presentation of primary SCCOC in a comprehensive cancer centre in Pakistan. Methods: Demographic, risk factors, pathological and AJCC staging data for SCCOC treated at Shaukat Khanum Memorial Hospital for the period November 2003-October 2008 were obtained from the head and neck unit database. Results: The database identified 666 patients with biopsy proven primary SCCOC. Mean age was 53 years (range 12 - 90 years). Male (428): Female (238) ratio was M64%:F36%. The occurrence of major risk factors for oral cancer specifically smoking, betel quid chewing, naswar (smokeless tobacco) and alcohol use in males (428) was 45% (193), 28% (118), 29% (126), 3% (13), and in females (238) was 8% (20), 29% (68), 13% (30), 0% (0), respectively. Thirty-eight percent (411/666) had no association with tobacco, betel quid or alcohol use. Subsite within oral cavity; anterior tongue 41.1% (274), buccal mucosa 26.6% (177), lower gingival and alveolus 19.5% (130), upper gingival and alveolus 4.1% (27), lips 3.6% (24), retromolar trigone 2.9% (19), hard palate 1.7% (11), and floor mouth 0.6 (4). Broder's/World Health Organization histological grade; grade I 52% (334), grade II 34% (226), grade III 7% (49), and unknown 5% (36). According to AJCC 2002 system 0.2% (1), 10.8% (72), 12.2% (81), 13.2% (88), and 63.7% (420) had stage 0, I, II, III, and IV, respectively. Conclusions: Approximately 80% of patients with primary SCCOC present with stage III or IV disease with anterior tongue as the most common subsite in our hospital. While tobacco and betel quid chewing can be attributed to development of SCCOC in a significant proportion of patients, nearly 38% are unlinked to typical risks factors suggesting other environmental and genetic agents as etiological factors in this region. No significant financial relationships to disclose.

scholarly journals Prevalence and genotype specific concordance of oro-genital and anal human papillomavirus infections among sexually active Nigerian women

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Imran O. Morhason-Bello ◽  
Kathy Baisley ◽  
Miquel Angel Pavon ◽  
Isaac F. Adewole ◽  
Rasheed Bakare ◽  
...  
Keyword(s):  
Risk Factors ◽  
Human Papillomavirus ◽  
Oral Cavity ◽  
Hpv Infection ◽  
Cross Sectional Study ◽  
Sub Saharan Africa ◽  
Sexually Active ◽  
Cross Sectional ◽  
Nigerian Women ◽  
Oral Hpv

Abstract Background Human papillomavirus (HPV) associated cancers are increasingly reported globally, including in sub-Saharan Africa (SSA). However, with the exception of cervical HPV infection, data from SSA on the epidemiology of oral and genital HPV infections are limited. This study assessed the prevalence and concordance of oro-genital and anal HPV genotype specific infections among women in the general population. Methods We conducted a cross-sectional study in sexually active women aged 18–45 years in Ibadan, Nigeria. After a face-to-face interview and clinical examination, oral, cervical, vulvar, and anal samples were collected from participants and tested by the Anyplex II 28 HPV assay. Descriptive and multivariable analyses were used to report prevalence and risk factors associated with HPV infections. Results The prevalence of any vulva, cervical, anal, and oral HPV infections was 68.0% (210/309), 59.7% (182/305), 56.8% (172/303), and 16.1% (14/286), respectively. There was an inverse relationship between age-group and HPV prevalence of HPV in all anatomic sites except for the oral HPV infections. HPV 35 was the most prevalent high-risk HPV genotype in the vulva, cervix and oral cavity. Associated risk factors for HPV infection in each of the anatomic sites were reported. Overall, 10.0% (31/310) women had concordance of any HPV type in the four anatomic sites. Conclusion There was a high prevalence of oro-genital and anal HPV infections among sexually active Nigerian women, with concordance of HPV types in the cervix, vulva, anus and oral cavity. We advocate large longitudinal studies that will involve sampling of multiple anatomic sites and inclusion of other women in the community for better understanding of HPV epidemiology in this region.

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