Branched-chain amino acids reduce hindlimb suspension-induced muscle atrophy and protein levels of atrogin-1 and MuRF1 in rats

2012 ◽  
Vol 32 (9) ◽  
pp. 676-683 ◽  
Author(s):  
Taiki Maki ◽  
Daisuke Yamamoto ◽  
Shiho Nakanishi ◽  
Keiji Iida ◽  
Genzo Iguchi ◽  
...  
Keyword(s):  
Amino Acids ◽  
Muscle Atrophy ◽  
Branched Chain Amino Acids ◽  
Hindlimb Suspension ◽  
Protein Levels ◽  
Branched Chain

Branched-chain amino acids protect against dexamethasone-induced soleus muscle atrophy in rats

2010 ◽  
Vol 41 (6) ◽  
pp. 819-827 ◽  
Author(s):  
Daisuke Yamamoto ◽  
Taiki Maki ◽  
Elizabeth Henny Herningtyas ◽  
Nobuko Ikeshita ◽  
Hiromi Shibahara ◽  
...  
Keyword(s):  
Amino Acids ◽  
Muscle Atrophy ◽  
Soleus Muscle ◽  
Branched Chain Amino Acids ◽  
Branched Chain

scholarly journals Long-Term Effects of Dietary Protein and Branched-Chain Amino Acids on Metabolism and Inflammation in Mice

Nutrients ◽  
2018 ◽  
Vol 10 (7) ◽  
pp. 918 ◽  
Author(s):  
Wei-Chieh Mu ◽  
Erin VanHoosier ◽  
Carrie Elks ◽  
Ryan Grant
Keyword(s):  
Amino Acids ◽  
Dietary Protein ◽  
Uncoupling Protein ◽  
Branched Chain Amino Acids ◽  
Protein Restriction ◽  
Metabolic Phenotype ◽  
Fibroblast Growth Factor 21 ◽  
Long Term Effects ◽  
Protein Levels ◽  
Branched Chain

Aging is the main factor involved in the onset of degenerative diseases. Dietary protein restriction has been shown to increase the lifespan of rodents and improve metabolic phenotype. Branched-chain amino acids (BCAA) can act as nutrient signals that increase the lifespan of mice after prolonged supplementation. It remains unclear whether the combination of protein restriction and BCAA supplementation improves metabolic and immunological profiles during aging. Here, we investigated how dietary protein levels and BCAA supplementation impact metabolism and immune profile during a 12-month intervention in adult male C57BL/6J mice. We found that protein restriction improved insulin tolerance and increased hepatic fibroblast growth factor 21 mRNA, circulating interleukin (IL)-5 concentration, and thermogenic uncoupling protein 1 in subcutaneous white fat. Surprisingly, BCAA supplementation conditionally increased body weight, lean mass, and fat mass, and deteriorated insulin intolerance during protein restriction, but not during protein sufficiency. BCAA also induced pro-inflammatory gene expression in visceral adipose tissue under both normal and low protein conditions. These results suggest that dietary protein levels and BCAA supplementation coordinate a complex regulation of metabolism and tissue inflammation during prolonged feeding.

scholarly journals Effect of branched-chain amino acids on muscle atrophy in cancer cachexia

2007 ◽  
Vol 407 (1) ◽  
pp. 113-120 ◽  
Author(s):  
Helen L. Eley ◽  
Steven T. Russell ◽  
Michael J. Tisdale
Keyword(s):  
Amino Acids ◽  
Muscle Atrophy ◽  
Cancer Cachexia ◽  
Branched Chain Amino Acids ◽  
Branched Chain

The Weight Loss Effects of Branched Chain Amino Acids and Vitamin B6: A Randomized Controlled Trial on Obese and Overweight Women

2018 ◽  
Vol 88 (1-2) ◽  
pp. 80-89 ◽  
Author(s):  
Zahra Shakibay Novin ◽  
Saeed Ghavamzadeh ◽  
Alireza Mehdizadeh
Keyword(s):  
Amino Acids ◽  
Weight Loss ◽  
Body Composition ◽  
Vitamin B6 ◽  
Controlled Trial ◽  
Density Lipoprotein ◽  
Branched Chain Amino Acids ◽  
Model Assessment ◽  
Waist To Hip Ratio ◽  
Branched Chain

Abstract. Branched chain amino acids (BCAA), with vitamin B6 have been reported to improve fat metabolism and muscle synthesis. We hypothesized that supplementation with BCAA and vitamin B6 would result in more weight loss and improve body composition and blood markers related to cardiovascular diseases. Our aim was to determine whether the mentioned supplementation would affect weight loss, body composition, and cardiovascular risk factors during weight loss intervention. To this end, we performed a placebo-controlled randomized clinical trial in 42 overweight and obese women (BMI = 25–34.9 kg/m2). Taking a four-week moderate deficit calorie diet (–500 kcal/day), participants were randomized to receive BCAA (6 g/day) with vitamin B6 (40 mg/day) or placebo. Body composition variables measured with the use of bioelectrical impedance analysis, homeostatic model assessment, and plasma insulin, Low density lipoprotein, High density lipoprotein, Total Cholesterol, Triglyceride, and fasting blood sugar were measured. The result indicated that, weight loss was not significantly affected by BCAA and vitamin B6 supplementation (–2.43 ± 1.02 kg) or placebo (–1.64 ± 1.48 kg). However, significant time × treatment interactions in waist to hip ratio (P = 0.005), left leg lean (P = 0.004) and right leg lean (P = 0.023) were observed. Overall, supplementation with BCAA and vitamin B6 could preserve legs lean and also attenuated waist to hip ratio.

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