scholarly journals Association between vitamin D receptor polymorphisms and multiple sclerosis: systematic review and meta-analysis of case–control studies

2014 ◽  
Vol 12 (2) ◽  
pp. 243-252 ◽  
Author(s):  
Kalthoum Tizaoui ◽  
Wajih Kaabachi ◽  
Agnès Hamzaoui ◽  
Kamel Hamzaoui
Keyword(s):  
Multiple Sclerosis ◽  
Systematic Review ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies

Association between VDR polymorphisms and multiple sclerosis: systematic review and updated meta-analysis of case-control studies

2017 ◽  
Vol 39 (2) ◽  
pp. 225-234 ◽  
Author(s):  
Yan-Jie Zhang ◽  
Li Zhang ◽  
Shan-Yu Chen ◽  
Guo-Jun Yang ◽  
Xiao-Lei Huang ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Systematic Review ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Vdr Polymorphisms

scholarly journals Traumatic Injury and Multiple Sclerosis: A Systematic Review and Meta-Analysis

2013 ◽  
Vol 40 (2) ◽  
pp. 168-176 ◽  
Author(s):  
Sharon A. Warren ◽  
Susan Armijo Olivo ◽  
Jorge Fuentes Contreras ◽  
Karen V. L. Turpin ◽  
Douglas P. Gross ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Systematic Review ◽  
Confidence Interval ◽  
Cohort Studies ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Traumatic Injury ◽  
Case Control ◽  
Case Control Studies ◽  
Newcastle Ottawa Scale

A systematic review/meta-analysis of literature addressing a possible association between traumatic injury and onset of multiple sclerosis was conducted. Medline, Embase, Cochrane DSR, Ovid HealthStar, CINAHL, ISI Web of Science and Scopus were searched for analytical studies from 1950 to 2011. Two investigators independently reviewed articles for inclusion, assessing their quality using the Newcastle-Ottawa Scale. Of the 13 case-control studies included, 8 were moderate quality and 5 low; of the 3 cohort studies 2 were high and 1 moderate. Meta-analysis including moderate and low quality case-control studies produced a modest but significant odds ratio: 1.41 (95% confidence interval: 1.03, 1.93). However, when low quality studies were excluded, the resulting odds ratio was non-significant. Cohort studies produced a non-significant standardized incidence ratio of 1.00 (95% confidence interval: 0.86, 1.16). These findings support the conclusion that there is no association between traumatic injury and multiple sclerosis onset; more high quality cohort studies would help to confirm this observation.

scholarly journals Association between vitamin D receptor (VDR) polymorphisms and the risk of multiple sclerosis (MS): an updated meta-analysis

BMC Neurology ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Danyal Imani ◽  
Bahman Razi ◽  
Morteza Motallebnezhad ◽  
Ramazan Rezaei
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Gene Polymorphisms ◽  
Genetic Model ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Asian Populations ◽  
Increased Risk ◽  
Apai Polymorphism

Abstract Background The association between the Vitamin D Receptor (VDR) gene polymorphism and the risk of Multiple sclerosis (MS) has been evaluated in several researches. However, the findings were inconsistent and inconclusive. Therefore, we set out a meta-analysis of all eligible published case-control studies to obtain an exact evaluation of the association between VDR gene polymorphisms and MS. Method All relevant studies reporting the association between the VDR gene FokI (rs2228570), or/and TaqI (rs731236) or/and BsmI (rs1544410) or/and ApaI (rs7975232) polymorphisms and susceptibility to MS published up to May, 2019 were identified by comprehensive systematic search in the electronic database of web of science, Scopus, and PubMed. After that, the strength of association between VDR gene polymorphisms and susceptibility to MS was evaluated by odds ratio (OR) and 95% confidence interval (CI). Results A total of 30 case–control studies were included in the meta-analysis. The overall results suggested a significant association between TaqI polymorphism and MS risk under heterozygote genetic model (OR = 1.27, 95%CI = 1.01–1.59, random effect). Moreover, the pooled results of subgroup analysis declined presence of significant association under all defined genetic model. In subgroup analysis, BsmI polymorphisms was associated with increased risk of MS under recessive model in Asian populations. On the other hand, ApaI polymorphism was associated with decreased risk of MS under recessive and aa vs. AA model in Asian populations. Conclusion This meta-analysis suggested a significant association between TaqI polymorphism and MS susceptibility. Furthermore, BsmI polymorphism was associated with increased risk of MS in Asian populations. In contrast, ApaI polymorphism was associated with decreased risk of MS in Asian populations. Future large-scale studies on gene–environment and gene–gene interactions are required to estimate risk factors and assist early diagnosis of patients at high risk for MS.

scholarly journals Vitamin D receptor gene polymorphisms and the risk of the type 1 diabetes: a meta-analysis based on 40 case–control studies

2020 ◽  
Author(s):  
Na Zhai ◽  
Ramtin Bidares ◽  
Masoud Hassanzadeh Makoui ◽  
Saeed Aslani ◽  
Payam Mohammadi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Type 1 Diabetes ◽  
Vitamin D Receptor ◽  
Subgroup Analysis ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Receptor Gene ◽  
Case Control ◽  
Case Control Studies

Abstract Background: The association between the polymorphisms in the vitamin D receptor (VDR) gene and the risk of type 1 diabetes mellitus (T1DM) has been evaluated in several studies. However, the findings were inconclusive. Thus, we conducted a meta-analysis to comprehensively evaluate the effect of VDR gene polymorphisms on the risk of T1DM.Methods: All relevant studies reporting the association between VDR gene polymorphisms and susceptibility to T1DM published up to May 2020 were identified by comprehensive systematic database search in ISI Web of Science, Scopus, and PubMed/MEDLINE. Strength of association were assessed by calculating of pooled odds ratios (ORs) and 95% confidence intervals (CIs). The methodological quality of each study was assessed according to the Newcastle–Ottawa Scale. To find the potential sources of heterogeneity, meta-regression and subgroup analysis were also performed. Results: A total of 40 case–control studies were included in this meta-analysis. The results of overall population rejected any significant association between VDR gene polymorphisms and T1DM risk. However, the pooled results of subgroup analysis revealed significant negative and positive associations between FokI and BsmI polymorphisms and T1DM in Africans and Americans, respectively. Conclusions: This meta-analysis suggested a significant association between VDR gene polymorphism and T1DM susceptibility in ethnic-specific analysis.

The role of calcium and vitamin D dietary intake on risk of colorectal cancer: systematic review and meta-analysis of case–control studies

2021 ◽  
Author(s):  
Juan Francisco Lopez-Caleya ◽  
Luis Ortega-Valín ◽  
Tania Fernández-Villa ◽  
Miguel Delgado-Rodríguez ◽  
Vicente Martín-Sánchez ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Vitamin D ◽  
Dietary Intake ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies

scholarly journals Pooling analysis regarding the impact of human vitamin D receptor variants on the odds of psoriasis

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Juan Li ◽  
Li Sun ◽  
Jinghui Sun ◽  
Min Yan
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Meta Analysis ◽  
Genetic Effect ◽  
Analysis Data ◽  
Case Control ◽  
Case Control Studies ◽  
Significant Difference ◽  
Meta Analyses ◽  
The Impact

Abstract Background The study aims at scientifically investigating the genetic effect of four polymorphisms (rs7975232, rs1544410, rs2228570, and rs731236) within the human Vitamin D Receptor (VDR) gene on the odds of psoriasis through an updated meta-analysis. Methods We searched eight databases and screened the studies for pooling. Finally, a total of eighteen eligible case-control studies were included. BH (Benjamini & Hochberg) adjusted P-values of association (Passociation) and odd ratios (ORs) with the corresponding 95% confidence intervals (CIs) were calculated under the allele, homozygote, heterozygote, dominant, recessive, and carrier models. Results Compared with the negative controls, no statistically significant difference in the odds of psoriasis was detected for the cases under any genetic models (BH adjusted Passociation > 0.05). We also performed subgroup meta-analyses by the source of controls, ethnicity, country, Hardy-Weinberg equilibrium, and genotyping method. Similar results were observed in most subgroup meta-analyses (BH adjusted Passociation > 0.05). Besides, data of Begg’s and Egger’s tests excluded the significant publication bias; while the sensitivity analysis data further indicated the statistical reliability of our pooling results. Conclusion The currently available data fails to support a robust association between VDR rs7975232, rs1544410, rs2228570 and rs731236 polymorphisms and psoriasis susceptibility, which still required the support of more case-control studies.

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