Diminished levels of regulatory T cell subsets (CD8+Foxp3, CD4+Foxp3 and CD4+CD39+Foxp3) but increased Foxp3 expression in adipose tissue from overweight subjects

Nutrition ◽  
2016 ◽  
Vol 32 (9) ◽  
pp. 943-954 ◽  
Author(s):  
Aleida Núñez Ruiz ◽  
Juan Diego Cortés-Garcia ◽  
Nancy Cortez-Espinosa ◽  
Paola Indira Herrera-Rojas ◽  
Víctor Manuel Ruíz-Rodríguez ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
T Cell ◽  
Regulatory T Cell ◽  
Foxp3 Expression ◽  
T Cell Subsets ◽  
Overweight Subjects

Tryptophan metabolism activation by indoleamine 2,3-dioxygenase in adipose tissue of obese women: an attempt to maintain immune homeostasis and vascular tone

2012 ◽  
Vol 303 (2) ◽  
pp. R135-R143 ◽  
Author(s):  
Isabelle Wolowczuk ◽  
Benjamin Hennart ◽  
Audrey Leloire ◽  
Alban Bessede ◽  
Marion Soichot ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
T Cell ◽  
White Adipose Tissue ◽  
Vascular Tone ◽  
T Cell Subsets ◽  
Low Grade ◽  
Adipose Tissues ◽  
Indoleamine 2,3 Dioxygenase ◽  
Arterial Blood ◽  
Ido1 Expression

Human obesity is characterized by chronic low-grade inflammation in white adipose tissue and is often associated with hypertension. The potential induction of indoleamine 2,3-dioxygenase-1 (IDO1), the rate-limiting enzyme in tryptophan/kynurenine degradation pathway, by proinflammatory cytokines, could be associated with these disorders but has remained unexplored in obesity. Using immunohistochemistry, we detected IDO1 expression in white adipose tissue of obese patients, and we focused on its contribution in the regulation of vascular tone and on its immunoregulatory effects. Concentrations of tryptophan and kynurenine were measured in sera of 36 obese and 15 lean women. The expression of IDO1 in corresponding omental and subcutaneous adipose tissues and liver was evaluated. Proinflammatory markers and T-cell subsets were analyzed in adipose tissue via the expression of CD14, IL-18, CD68, TNFα, CD3ε, FOXP3 [a regulatory T-cell (Treg) marker] and RORC (a Th17 marker). In obese subjects, the ratio of kynurenine to tryptophan, which reflects IDO1 activation, is higher than in lean subjects. Furthermore, IDO1 expression in both adipose tissues and liver is increased and is inversely correlated with arterial blood pressure. Inflammation is associated with a T-cell infiltration in obese adipose tissue, with predominance of Th17 in the omental compartment and of Treg in the subcutaneous depot. The Th17/Treg balance is decreased in subcutaneous fat and correlates with IDO1 activation. In contrast, in the omental compartment, despite IDO1 activation, the Th17/Treg balance control is impaired. Taken together, our results suggest that IDO1 activation represents a local compensatory mechanism to limit obesity-induced inflammation and hypertension.

scholarly journals Regulatory T cell subsets in patients with medulloblastoma at diagnosis and during standard irradiation and chemotherapy (PBTC N-11)

2017 ◽  
Vol 66 (12) ◽  
pp. 1589-1595 ◽  
Author(s):  
Sridharan Gururangan ◽  
Elizabeth Reap ◽  
Robert Schmittling ◽  
Mehmet Kocak ◽  
Renee Reynolds ◽  
...  
Keyword(s):  
T Cell ◽  
Regulatory T Cell ◽  
T Cell Subsets

scholarly journals Assessment of CD39 expression in regulatory T cell subsets by disease severity in adult and juvenile COVID ‐19 cases

2022 ◽  
Author(s):  
Abdurrahman Simsek ◽  
Muhammed Ali Kizmaz ◽  
Eren Cagan ◽  
Fatma Dombaz ◽  
Gulcin Tezcan ◽  
...  
Keyword(s):  
T Cell ◽  
Disease Severity ◽  
Regulatory T Cell ◽  
T Cell Subsets

scholarly journals Distinct Blood and Visceral Adipose Tissue Regulatory T Cell and Innate Lymphocyte Profiles Characterize Obesity and Colorectal Cancer

2017 ◽  
Vol 8 ◽  
Author(s):  
Gloria Donninelli ◽  
Manuela Del Cornò ◽  
Marina Pierdominici ◽  
Beatrice Scazzocchio ◽  
Rosaria Varì ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Adipose Tissue ◽  
T Cell ◽  
Visceral Adipose Tissue ◽  
Regulatory T Cell ◽  
Visceral Adipose

Differential profile of activated regulatory T cell subsets and microRNAs in tolerant liver transplant recipients

2017 ◽  
Vol 23 (7) ◽  
pp. 933-945 ◽  
Author(s):  
Beatriz Revilla-Nuin ◽  
África de Bejar ◽  
Laura Martínez-Alarcón ◽  
José Ignacio Herrero ◽  
Carlos Manuel Martínez-Cáceres ◽  
...  
Keyword(s):  
T Cell ◽  
Liver Transplant ◽  
Regulatory T Cell ◽  
T Cell Subsets ◽  
Transplant Recipients ◽  
Liver Transplant Recipients

scholarly journals Differential effects of 2-deoxy-D-glucose on in vitro expanded human regulatory T cell subsets

PLoS ONE ◽  
2019 ◽  
Vol 14 (6) ◽  
pp. e0217761 ◽  
Author(s):  
Naoki Tanimine ◽  
Sharon K. Germana ◽  
Martin Fan ◽  
Keli Hippen ◽  
Bruce R. Blazar ◽  
...  
Keyword(s):  
T Cell ◽  
Regulatory T Cell ◽  
T Cell Subsets ◽  
Differential Effects

Cytokines in the generation and function of regulatory T cell subsets in leishmaniasis

Cytokine ◽  
2020 ◽  
pp. 155266 ◽  
Author(s):  
Sanhita Ghosh ◽  
Kamalika Roy ◽  
Radhakrishnan Rajalingam ◽  
Sunil Martin ◽  
Chiranjib Pal
Keyword(s):  
T Cell ◽  
Regulatory T Cell ◽  
T Cell Subsets ◽  
And Function
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