Preexercise ingestion of carbohydrate plus whey protein hydrolysates attenuates skeletal muscle glycogen depletion during exercise in rats

Nutrition ◽  
2011 ◽  
Vol 27 (7-8) ◽  
pp. 833-837 ◽  
Author(s):  
Masashi Morifuji ◽  
Atsushi Kanda ◽  
Jinichiro Koga ◽  
Kentaro Kawanaka ◽  
Mitsuru Higuchi
Keyword(s):  
Skeletal Muscle ◽  
Whey Protein ◽  
Muscle Glycogen ◽  
Protein Hydrolysates ◽  
Glycogen Depletion ◽  
Whey Protein Hydrolysates ◽  
Skeletal Muscle Glycogen

Post-exercise carbohydrate plus whey protein hydrolysates supplementation increases skeletal muscle glycogen level in rats

Amino Acids ◽  
2009 ◽  
Vol 38 (4) ◽  
pp. 1109-1115 ◽  
Author(s):  
Masashi Morifuji ◽  
Atsushi Kanda ◽  
Jinichiro Koga ◽  
Kentaro Kawanaka ◽  
Mitsuru Higuchi
Keyword(s):  
Skeletal Muscle ◽  
Whey Protein ◽  
Muscle Glycogen ◽  
Protein Hydrolysates ◽  
Glycogen Level ◽  
Post Exercise ◽  
Whey Protein Hydrolysates ◽  
Skeletal Muscle Glycogen ◽  
Muscle Glycogen Level

Dietary Whey Protein Hydrolysates Increase Skeletal Muscle Glycogen Levels via Activation of Glycogen Synthase in Mice

2012 ◽  
Vol 60 (45) ◽  
pp. 11403-11408 ◽  
Author(s):  
Atsushi Kanda ◽  
Masashi Morifuji ◽  
Tomoyuki Fukasawa ◽  
Jinichiro Koga ◽  
Minoru Kanegae ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Whey Protein ◽  
Muscle Glycogen ◽  
Glycogen Synthase ◽  
Protein Hydrolysates ◽  
Whey Protein Hydrolysates ◽  
Skeletal Muscle Glycogen

scholarly journals Soluble Whey Protein Hydrolysate Ameliorates Muscle Atrophy Induced by Immobilization via Regulating the PI3K/Akt Pathway in C57BL/6 Mice

Nutrients ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3362
Author(s):  
Ji Eun Shin ◽  
Seok Jun Park ◽  
Seung Il Ahn ◽  
Se-Young Choung
Keyword(s):  
Skeletal Muscle ◽  
Whey Protein ◽  
Muscle Mass ◽  
Muscle Atrophy ◽  
Skeletal Muscle Mass ◽  
Protein Hydrolysate ◽  
Protein Hydrolysates ◽  
Protein Supplementation ◽  
Whey Protein Hydrolysates ◽  
Whey Protein Hydrolysate

Sarcopenia, a loss of skeletal muscle mass and function, is prevalent in older people and associated with functional decline and mortality. Protein supplementation is necessary to maintain skeletal muscle mass and whey protein hydrolysates have the best nutrient quality among food proteins. In the first study, C57BL/6 mice were subjected to immobilization for 1 week to induce muscle atrophy. Then, mice were administered with four different whey protein hydrolysates for 2 weeks with continuous immobilization. Among them, soluble whey protein hydrolysate (WP-S) had the greatest increase in grip strength, muscle weight, and cross-sectional area of muscle fiber than other whey protein hydrolysates. To investigate the molecular mechanism, we conducted another experiment with the same experimental design. WP-S significantly promoted the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway and inhibited the PI3K/Akt/forkhead box O (FoxO) pathway. In addition, it increased myosin heavy chain (MyHC) expression in both the soleus and quadriceps and changed MyHC isoform expressions. In conclusion, WP-S attenuated muscle atrophy induced by immobilization by enhancing the net protein content regulating muscle protein synthesis and degradation. Thus, it is a necessary and probable candidate for developing functional food to prevent sarcopenia.

scholarly journals Dietary whey protein increases liver and skeletal muscle glycogen levels in exercise-trained rats

2005 ◽  
Vol 93 (4) ◽  
pp. 439-445 ◽  
Author(s):  
Masashi Morifuji ◽  
Kensuke Sakai ◽  
Chiaki Sanbongi ◽  
Katsumi Sugiura
Keyword(s):  
Skeletal Muscle ◽  
Whey Protein ◽  
Muscle Glycogen ◽  
Dietary Protein ◽  
Glycogen Content ◽  
Glycogen Synthase ◽  
Casein Diet ◽  
Skeletal Muscle Glycogen ◽  
Protein Group ◽  
Glycogen Synthase Activity

We investigated the effect of different types of dietary protein on glycogen content in liver and skeletal muscle of exercise-trained rats. Twenty-four male Sprague-Dawley rats (approximately 100 g; n 6 per group) were divided into sedentary or exercise-trained groups with each group being fed either casein or whey protein as the source of dietary protein. Rats in the exercised groups were trained during 2 weeks using swimming exercise for 120 min/d, 6 d/week. Exercise training resulted in an increase in the skeletal muscle glycogen content. Furthermore, the whey protein group significantly increased the skeletal muscle glycogen content compared with the casein group. The increase in glycogen content in liver was significantly greater in rats fed the whey protein diet compared with those fed the casein diet. We also found that the whey protein diet increased the activity of liver glucokinase, whereas it decreased the activities of 6-phosphofructokinase and pyruvate kinase compared with the casein diet. However, hepatic total glycogen synthase activity and mRNA expression were similar with the two diets. In the skeletal muscle, whey protein decreased only 6-phosphofructokinase activity compared with casein. Total glycogen synthase activity in the skeletal muscle in the whey protein group was significantly higher than that in the casein group. The present study is the first to demonstrate that a diet based on whey protein may increase glycogen content in liver and skeletal muscle of exercise-trained rats. We also observed that whey protein regulated glycogen metabolism in these two tissues by different mechanisms.

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