Skeletal muscle glycogen depletion during submaximal exercise in rats with chronic heart failure

1990 ◽  
Vol 85 (6) ◽  
pp. 606-618 ◽  
Author(s):  
T. I. Musch ◽  
M. R. Ghaul ◽  
V. Tranchitella ◽  
R. Zelis
Keyword(s):  
Heart Failure ◽  
Skeletal Muscle ◽  
Chronic Heart Failure ◽  
Muscle Glycogen ◽  
Submaximal Exercise ◽  
Glycogen Depletion ◽  
Skeletal Muscle Glycogen

Human Skeletal Muscle Glycogen Branching Enzyme Activities with Exercise and Training

1974 ◽  
Vol 52 (1) ◽  
pp. 119-122 ◽  
Author(s):  
A. W. Taylor ◽  
J. Stothart ◽  
M. A. Booth ◽  
R. Thayer ◽  
S. Rao
Keyword(s):  
Skeletal Muscle ◽  
Muscle Glycogen ◽  
Enzyme Activities ◽  
Vastus Lateralis ◽  
Submaximal Exercise ◽  
Relative Fitness ◽  
Vastus Lateralis Muscle ◽  
Branching Enzyme ◽  
Skeletal Muscle Glycogen ◽  
Glycogen Branching Enzyme

Sixteen healthy male subjects classified as sedentary (8) or active (8), exercised to exhaustion on a bicycle ergometer at a load requiring 70% of their maximal aerobic capacity. Biopsy samples of the vastus lateralis muscle were taken at rest and at the time of fatigue. A 12 week training program increased skeletal muscle glycogen content and branching enzyme activities twofold. The exhaustive submaximal exercise reduced the glycogen levels of the trained group to values similar to the fatigue levels of the non-trained subjects. Skeletal muscle glycogen branching enzyme activities decreased with submaximal exercise to fatigue in all groups. Maximal exercise to fatigue resulted in small increases in the activities of the enzyme. The results of the present study and a previous study (Taylor et al. 1972. Can. J. Physiol. Pharmacol. 50, 411–415) indicate that the activities of the glycogen synthesizing enzymes are highly correlated with the skeletal muscle resting glycogen concentration and the relative fitness of the subjects.

Skeletal muscle metabolic recovery following submaximal exercise in chronic heart failure is limited more by O2 delivery than O2 utilization

2010 ◽  
Vol 118 (3) ◽  
pp. 203-210 ◽  
Author(s):  
Hareld M.C. Kemps ◽  
Jeanine J. Prompers ◽  
Bart Wessels ◽  
Wouter R. De Vries ◽  
Maria L. Zonderland ◽  
...  
Keyword(s):  
Heart Failure ◽  
Skeletal Muscle ◽  
Chronic Heart Failure ◽  
Submaximal Exercise ◽  
Daily Activities ◽  
Control Group ◽  
Resonance Spectroscopy ◽  
Post Exercise ◽  
Metabolic Recovery ◽  
O2 Delivery

CHF (chronic heart failure) is associated with a prolonged recovery of skeletal muscle energy stores following submaximal exercise, limiting the ability to perform repetitive daily activities. However, the pathophysiological background of this impairment is not well established. The aim of the present study was to investigate whether muscle metabolic recovery following submaximal exercise in patients with CHF is limited by O2 delivery or O2 utilization. A total of 13 stable CHF patients (New York Heart Association classes II–III) and eight healthy subjects, matched for age and BMI (body mass index), were included. All subjects performed repetitive submaximal dynamic single leg extensions in the supine position. Post-exercise PCr (phosphocreatine) resynthesis was assessed by 31P-MRS (magnetic resonance spectroscopy). NIRS (near-IR spectroscopy) was applied simultaneously, using the rate of decrease in HHb (deoxygenated haemoglobin) as an index of post-exercise muscle re-oxygenation. As expected, PCr recovery was slower in CHF patients than in control subjects (time constant, 47±10 compared with 35±12 s respectively; P=0.04). HHb recovery kinetics were also prolonged in CHF patients (mean response time, 74±41 compared with 44±17 s respectively; P=0.04). In the patient group, HHb recovery kinetics were slower than PCr recovery kinetics (P=0.02), whereas no difference existed in the control group (P=0.32). In conclusion, prolonged metabolic recovery in CHF patients is associated with an even slower muscle tissue re-oxygenation, indicating a lower O2 delivery relative to metabolic demands. Therefore we postulate that the impaired ability to perform repetitive daily activities in these patients depends more on a reduced muscle blood flow than on limitations in O2 utilization.

Glycogen concentrations and endurance capacity of rats with chronic heart failure

1988 ◽  
Vol 64 (3) ◽  
pp. 1153-1159 ◽  
Author(s):  
T. I. Musch ◽  
R. L. Moore ◽  
M. Riedy ◽  
P. Burke ◽  
R. Zelis ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Submaximal Exercise ◽  
Myocardial Infarctions ◽  
Endurance Capacity ◽  
Glycogen Depletion ◽  
Control Groups ◽  
Exercise Regimen ◽  
Glycogen Utilization ◽  
White Gastrocnemius

The endurance capacities of rats with myocardial infarctions (MI) and of rats having undergone sham operations (SHAM) were tested during a submaximal exercise regimen that consisted of swimming to exhaustion. During this test, a decrement in the endurance capacity of the MI rat was demonstrated as the SHAM rat swam 25% longer than the MI rat (65 ± 4 vs. 52 ± 4 min). Glycogen concentrations were measured in the liver and the white gastrocnemius, plantaris, and soleus muscles of SHAM and MI rats that were randomly divided into four subgroups, which consisted of resting control, swim to exhaustion, swim to exhaustion + 24 h recovery, and swim to exhaustion + 24 h recovery + a second swim to exhaustion. The results demonstrated that the glycogen concentrations found in the liver, white gastrocnemius, plantaris, and soleus muscles of the SHAM and MI rats belonging to the resting control groups were similar. After swimming to exhaustion the glycogen concentrations in these tissues were significantly reduced compared with those found in the resting control groups of rats, and after 24 h of recovery the glycogen concentrations in these tissues were again similar to those found in the resting control groups of rats. Since the magnitude of the glycogen depletion in the liver and the white gastrocnemius, plantaris, and soleus muscles was similar in the SHAM and MI rats and because the SHAM rats consistently swam for longer periods of time in each of the experimental groups, it would be logical to assume that the rates of glycogen utilization for the various tissues may have been greater in the MI rat during exercise.(ABSTRACT TRUNCATED AT 250 WORDS)

Preexercise ingestion of carbohydrate plus whey protein hydrolysates attenuates skeletal muscle glycogen depletion during exercise in rats

Nutrition ◽  
2011 ◽  
Vol 27 (7-8) ◽  
pp. 833-837 ◽  
Author(s):  
Masashi Morifuji ◽  
Atsushi Kanda ◽  
Jinichiro Koga ◽  
Kentaro Kawanaka ◽  
Mitsuru Higuchi
Keyword(s):  
Skeletal Muscle ◽  
Whey Protein ◽  
Muscle Glycogen ◽  
Protein Hydrolysates ◽  
Glycogen Depletion ◽  
Whey Protein Hydrolysates ◽  
Skeletal Muscle Glycogen

scholarly journals Skeletal-muscle glycogen synthesis during the starved-to-fed transition in the rat

1988 ◽  
Vol 254 (3) ◽  
pp. 855-859 ◽  
Author(s):  
M J Holness ◽  
M J L Schuster-Bruce ◽  
M C Sugden
Keyword(s):  
Skeletal Muscle ◽  
Muscle Glycogen ◽  
Glycogen Synthesis ◽  
Glucose Disposal ◽  
Glycogen Depletion ◽  
Fibre Composition ◽  
Skeletal Muscle Glycogen ◽  
Muscle Glycogen Synthesis ◽  
Muscle Fibre Composition ◽  
Glycogen Deposition

The pattern of glycogen deposition in skeletal muscles of varying fibre composition was examined in rats during the starved-to-fed transition. In all the muscles studied, glycogen concentrations steadily increased during the first 8 h after chow re-feeding, and the fed value was exceeded. Rates of glycogen deposition varied, not with muscle fibre composition, but with the extent of glycogen depletion during starvation. There was no evidence for skeletal-muscle glycogen breakdown during the period of hepatic glycogenesis, making it unlikely that recycling of carbon from muscle glycogen to lactate is quantitatively important for the provision of glycogenic precursors to the liver, but moderate glycogen loss was observed from 8 to 24 h after re-feeding, when the liver is in the lipogenic mode. The factors influencing glucose disposal by skeletal muscle after re-feeding are discussed.

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