Melanocortin-3 receptor gene variants: Association with childhood obesity and eating behavior in Chilean families

Nutrition ◽  
2010 ◽  
Vol 26 (7-8) ◽  
pp. 760-765 ◽  
Author(s):  
A.M. Obregón ◽  
P. Amador ◽  
M. Valladares ◽  
G. Weisstaub ◽  
R. Burrows ◽  
...  
Keyword(s):  
Childhood Obesity ◽  
Eating Behavior ◽  
Receptor Gene ◽  
Gene Variants

Melanocortin-4 receptor gene variants in Chilean families: association with childhood obesity and eating behavior

2010 ◽  
Vol 13 (2) ◽  
pp. 71-78 ◽  
Author(s):  
M. Valladares ◽  
P. Domínguez-Vásquez ◽  
A.M. Obregón ◽  
G. Weisstaub ◽  
R. Burrows ◽  
...  
Keyword(s):  
Childhood Obesity ◽  
Eating Behavior ◽  
Receptor Gene ◽  
Gene Variants ◽  
Melanocortin 4 Receptor ◽  
Melanocortin 4 Receptor Gene

Melanocortin-4 receptor gene variants are not associated with binge-eating behavior in nonobese patients with eating disorders

2015 ◽  
Vol 25 (1) ◽  
pp. 35-38 ◽  
Author(s):  
Carmen Gamero-Villarroel ◽  
Raquel Rodriguez-Lopez ◽  
Mercedes Jimenez ◽  
Juan A. Carrillo ◽  
Angustias Garcia-Herraiz ◽  
...  
Keyword(s):  
Eating Disorders ◽  
Binge Eating ◽  
Eating Behavior ◽  
Receptor Gene ◽  
Gene Variants ◽  
Melanocortin 4 Receptor ◽  
Melanocortin 4 Receptor Gene ◽  
Nonobese Patients

Evidence of Addictive-Like Eating Behavior in Childhood Obesity

2012 ◽  
Author(s):  
Ashley N. Gearhardt ◽  
Christina A. Roberto ◽  
Marissa J. Seamans ◽  
William R. Corbin ◽  
Kelly D. Brownell
Keyword(s):  
Childhood Obesity ◽  
Eating Behavior

Melanocortin-4 Receptor Gene Variation Is Associated with Eating Behavior in Chilean Adults

2015 ◽  
Vol 68 (1) ◽  
pp. 35-41 ◽  
Author(s):  
Javier A. Vega ◽  
Gloria Salazar ◽  
María Isabel Hodgson ◽  
Luis Rodrigo Cataldo ◽  
Macarena Valladares ◽  
...  
Keyword(s):  
Eating Behavior ◽  
Emotional Eating ◽  
Leptin Receptor ◽  
Receptor Gene ◽  
Pathogenic Mutation ◽  
Gene Variation ◽  
Mc4r Gene ◽  
Melanocortin 4 Receptor ◽  
Melanocortin 4 Receptor Gene ◽  
Mc4r Rs17782313

Background/Aims: To evaluate the association between allelic variants of melanocortin receptors -3 and -4 (MC3R and MC4R, respectively) and leptin receptor (LEPR) genes with body mass index (BMI) and eating behavior. Methods: We selected 344 Chilean adults (57.8% women; age 39.1 ± 6.6 years) with a wide variation in BMI (30.3 ± 6.3 kg/m2). The Three-Factor Eating Questionnaire-R18 that measures uncontrolled eating (UE), emotional eating (EE) and cognitive restraint scores was adapted, validated and assessed for association with BMI. Genotypes were determined by polymerase chain reaction followed by restriction fragment length polymorphism techniques and Taqman assays. Results: Higher EE scores were found in obese vs. non-obese in both men (p = 0.01) and women (p < 0.001). UE scores were significantly associated with BMI only in women (p = 0.002). No significant differences in eating behavior scores or BMI were found by LEPR (rs1137101, rs8179183 and rs1137100 polymorphisms) or MC3R (rs3746619 and rs3827103). Carriers of the C allele for MC4R rs17782313 showed significantly higher scores of UE compared to non-carriers (2.3 ± 0.8 vs. 2.0 ± 0.7; p = 0.02). Additionally, we also report a monogenic case of obesity carrying the pathogenic mutation 449C>T (Thr150Ile) in MC4R gene with no apparent alterations in eating behavior scores. Conclusions: UE scores were higher in C-allele carriers of MC4R-rs17782313 compared to non-carriers.

Histamine H3 receptor gene variants associated with drug abuse in patients with cocaine use disorder

2020 ◽  
Vol 34 (11) ◽  
pp. 1326-1330
Author(s):  
Iñigo Pallardo-Fernández ◽  
José Ramón Muñoz-Rodríguez ◽  
Carmen González-Martín ◽  
Luis F Alguacil
Keyword(s):  
Drug Abuse ◽  
Single Nucleotide Polymorphisms ◽  
Receptor Gene ◽  
Gene Variants ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Histamine H3 Receptor ◽  
Cocaine Use ◽  
H3 Receptor ◽  
Histamine H3

Background: Preclinical work revealed significant interactions between ligands of the histamine H3 receptor and different drugs of abuse. In the case of psychostimulants, the results reported are somewhat controversial and human data are still scarce, despite the fact that an inverse agonist of the H3 receptor (pitolisant) has reached the market after approval for the treatment of narcolepsy. Aims: We have studied associations between histamine H3 receptor gene variants and cocaine use disorder to increase the knowledge of the possible involvement of histamine H3 receptor in drug abuse. Methods: Seven single nucleotide polymorphisms of the histamine H3 receptor gene were genotyped by using a multiplexing assay in 248 samples of subjects with cocaine use disorder and 500 randomized samples of subjects representative of the Spanish population. Results: The study of the epidemiological information associated to the samples revealed that subjects with cocaine use disorder broadly abused alcohol, tobacco and cannabinoids. Two single nucleotide polymorphisms (rs3787430 and rs74627870) were found significantly associated with the occurrence of addiction and one more (rs13042865) was specifically related to the severity of cocaine dependence within drug abusers. Conclusions: The associations found in this study further extend the hypothesis that histamine H3 receptor function could be relevant in drug abuse in general and cocaine addiction in particular.

scholarly journals Progesterone Receptor Gene Variants in Metastatic Estrogen Receptor Positive Breast Cancer

2020 ◽  
Vol 11 (2) ◽  
pp. 63-75 ◽  
Author(s):  
Amy M. Fowler ◽  
Kelley Salem ◽  
Michael DeGrave ◽  
Irene M. Ong ◽  
Shane Rassman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Progesterone Receptor ◽  
Receptor Gene ◽  
Gene Variants ◽  
Progesterone Receptor Gene ◽  
Estrogen Receptor Positive ◽  
Positive Breast Cancer

Effects of β2-Adrenergic Receptor Gene Variants on Adiposity: The HERITAGE Family Study

2003 ◽  
Vol 11 (5) ◽  
pp. 612-618 ◽  
Author(s):  
Christophe Garenc ◽  
Louis Pérusse ◽  
Yvon C. Chagnon ◽  
Tuomo Rankinen ◽  
Jacques Gagnon ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Family Study ◽  
Receptor Gene ◽  
Gene Variants ◽  
Β2 Adrenergic Receptor ◽  
Adrenergic Receptor Gene
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