Melanocortin-4 Receptor Gene Variation Is Associated with Eating Behavior in Chilean Adults

2015 ◽  
Vol 68 (1) ◽  
pp. 35-41 ◽  
Author(s):  
Javier A. Vega ◽  
Gloria Salazar ◽  
María Isabel Hodgson ◽  
Luis Rodrigo Cataldo ◽  
Macarena Valladares ◽  
...  
Keyword(s):  
Eating Behavior ◽  
Emotional Eating ◽  
Leptin Receptor ◽  
Receptor Gene ◽  
Pathogenic Mutation ◽  
Gene Variation ◽  
Mc4r Gene ◽  
Melanocortin 4 Receptor ◽  
Melanocortin 4 Receptor Gene ◽  
Mc4r Rs17782313

Background/Aims: To evaluate the association between allelic variants of melanocortin receptors -3 and -4 (MC3R and MC4R, respectively) and leptin receptor (LEPR) genes with body mass index (BMI) and eating behavior. Methods: We selected 344 Chilean adults (57.8% women; age 39.1 ± 6.6 years) with a wide variation in BMI (30.3 ± 6.3 kg/m2). The Three-Factor Eating Questionnaire-R18 that measures uncontrolled eating (UE), emotional eating (EE) and cognitive restraint scores was adapted, validated and assessed for association with BMI. Genotypes were determined by polymerase chain reaction followed by restriction fragment length polymorphism techniques and Taqman assays. Results: Higher EE scores were found in obese vs. non-obese in both men (p = 0.01) and women (p < 0.001). UE scores were significantly associated with BMI only in women (p = 0.002). No significant differences in eating behavior scores or BMI were found by LEPR (rs1137101, rs8179183 and rs1137100 polymorphisms) or MC3R (rs3746619 and rs3827103). Carriers of the C allele for MC4R rs17782313 showed significantly higher scores of UE compared to non-carriers (2.3 ± 0.8 vs. 2.0 ± 0.7; p = 0.02). Additionally, we also report a monogenic case of obesity carrying the pathogenic mutation 449C>T (Thr150Ile) in MC4R gene with no apparent alterations in eating behavior scores. Conclusions: UE scores were higher in C-allele carriers of MC4R-rs17782313 compared to non-carriers.

scholarly journals Effect of MC4R gene polymorphism on food intake in adolescents with overweight and obesity

2019 ◽  
Vol 16 (2) ◽  
pp. 22-28
Author(s):  
Kseniya D. Ievleva ◽  
Tatyana A. Bairova ◽  
Ekaterina A. Sheneman ◽  
Varvara V. Balzhieva ◽  
Zhanna G. Ayurova ◽  
...  
Keyword(s):  
Receptor Gene ◽  
Overweight And Obesity ◽  
Control Group ◽  
Control Groups ◽  
Anthropometric Parameters ◽  
Mc4r Gene ◽  
Melanocortin 4 Receptor ◽  
Melanocortin 4 Receptor Gene ◽  
Mc4r Rs17782313 ◽  
Relationship Of

BACKGROUND: The melanocortin 4 receptor gene (MC4R) codes the receptor expressed in the hypothalamus and involved in the regulation of body mass and height. Data on the association of polymorphism MC4R rs17782313 with anthropometric parameters are contradictory. AIMS: to study the influence of the carrier of polymorphism MC4R rs17782313 on the anthropometric parameters in adolescents of different ethnic groups: caucasians and mongoloids living in the Siberia. MATERIALS AND METHODS: The study included 179 caucasian adolescents (by the example of russians, average age is 15.07 1.25 years) and 182 mongoloid adolescents (by the example of the buryats, the average age is 14.71 1.28 years), 89 and 92 adolescents were included in groups with overweight and obesity (standard deviation (SDS) BMI 1), in the control groups (SDS BMI from -1 to + 1) also 90 and 90 adolescents were included in the control groups (SDS BMI from -1 to + 1) (russian and buryat, respectively). Anthropometric measurements included height, weight with the calculation of BMI and SDS BMI, WC (waist circumference), HC (hip circumference ). Genotyping was performed by real-time PCR. Statistical analysis of the results of the study was carried out using the software STATISTICA 8.0. RESULTS: We showed no association of the risky C-allele of polymorphism rs17782313 with overweight and obesity in russian adolescents (22.5% vs 17.9% OR = 1.34 (p 0.05)) and in the buryat (29.8% vs 24.1%, OR = 1.43 (p 0.05)). It was revealed that adolescent carriers of the C-allele in buryat showed higher growth in both groups (control: 162.19 cm vs 157.26 cm (p = 0.019)), the main group: 165.24 cm vs 164.91 cm (p = 0.041)), as well as weight gain in the control group (52.29 kg vs 48.05 kg (p = 0.028)). CONCLUSIONS: Thus, the study revealed the relationship of MC4R rs17782313 polymorphism with height and weight in adolescents of buryat ethnic group.

scholarly journals Melanocortin-4 Receptor Gene Mutations in Obese Slovak Children

2015 ◽  
pp. 883-890 ◽  
Author(s):  
D. STANIKOVA ◽  
M. SUROVA ◽  
L. TICHA ◽  
M. PETRASOVA ◽  
D. VIRGOVA ◽  
...  
Keyword(s):  
Sanger Sequencing ◽  
Dna Analysis ◽  
Receptor Gene ◽  
Gene Mutations ◽  
Loss Of Function ◽  
Obese Children ◽  
Mc4r Gene ◽  
Melanocortin 4 Receptor ◽  
Melanocortin 4 Receptor Gene ◽  
Common Etiology

The most common etiology of non-syndromic monogenic obesity are mutations in gene for the Melanocortin-4 receptor (MC485) with variable prevalence in different countries (1.2-6.3 % of obese children). The aim of our study was 1) to search for MC4R mutations in obese children in Slovakia and compare their prevalence with other European countries, and 2) to describe the phenotype of the mutation carriers. DNA analysis by direct Sanger sequencing of the coding exons and intron/exon boundaries of the MC4R gene was performed in 268 unrelated Slovak children and adolescents with body mass index above the 97th percentile for age and sex and obesity onset up to 11 years (mean 4.3±2.8 years). Two different previously described heterozygous loss of function MC4R variants (i.e. p.Ser19Alafs*34, p.Ser127Leu) were identified in two obese probands, and one obese (p.Ser19Alafs*34), and one lean (p.Ser127Leu) adult family relatives. No loss of function variants were found in lean controls. The prevalence of loss-of-function MC4R variants in obese Slovak children was 0.7 %, what is one of the lowest frequencies in Europe.

Melanocortin-4 receptor gene variants in Chilean families: association with childhood obesity and eating behavior

2010 ◽  
Vol 13 (2) ◽  
pp. 71-78 ◽  
Author(s):  
M. Valladares ◽  
P. Domínguez-Vásquez ◽  
A.M. Obregón ◽  
G. Weisstaub ◽  
R. Burrows ◽  
...  
Keyword(s):  
Childhood Obesity ◽  
Eating Behavior ◽  
Receptor Gene ◽  
Gene Variants ◽  
Melanocortin 4 Receptor ◽  
Melanocortin 4 Receptor Gene

scholarly journals Association of Melanocortin 4 Receptor gene polymorphism with growth traits in Bligon goat

2018 ◽  
Vol 43 (4) ◽  
pp. 343 ◽  
Author(s):  
L. Latifah ◽  
D. Maharani ◽  
A. Kustantinah ◽  
T. Hartatik
Keyword(s):  
Growth Traits ◽  
Receptor Gene ◽  
Marker Gene ◽  
Average Daily Gain ◽  
Mc4r Gene ◽  
Relationship Analysis ◽  
Melanocortin 4 Receptor ◽  
Genotype Frequencies ◽  
Potential Marker ◽  
Melanocortin 4 Receptor Gene

Melanocortin 4 receptor gene is a potential marker gene for growth performance in ruminant and non-ruminant animals. The objective of this study was to perform allele and genotype frequencies, and association of melanocortin 4 receptor with growth traits in Bligon goat. Seventy seven blood samples were collected and DNA isolated successfully. One pair primers were used for PCR of MC4R gene (F: 5’-TCGGGCGTCTTGTTCATCAT-3’ and R: 5’-CAAGACTGGGCACTGCTTCA-3’). Two SNPs (g.998A/G and g.1079C/T) were identified in exon of Bligon MC4R by DNA sequencing and PCR-RFLP. The SNP g.998A/G identified amino acid change from isoleucine to methionine (I-M), while the SNP g.1079C/T was synonymous polymorphism. Based on relationship analysis between Genotype of MC4R gene (SNP g.998A/G) and growth traits indicated that GG genotype was lowest in weaning weight (WW; AA=13.0±1.7; AG=11.2±3.6; GG=9.2±3.9), weaning body length (WBL; AA=46.8±2.4; AG=46.3±6.0; GG=43.8±5.3) and weaning chest circumference (WCC; AA=50.9±4.0; AG=50.7±4.6; GG=47.1±7.3) compare to AA and AG genotype (p<0.05). Individual with CC and CT genotypes at SNP g.1079C/T had higher (P<0.05) in WW (CC=12.6±2.1; CT=12.5±2.5) and average daily gain (ADG; CC=81.2±21.8; CT=79.3±26.2) than TT genotype (WW=10.6±3.1; ADG=58.3±30.5). This results suggested that SNP g.998A/G and g.1079C/T of MC4R gene could be used as the genetic marker of growth traits for selection in Bligon goat.

scholarly journals Melanocortin 4 Receptor Gene Variation Is Associated With Severe Obesity in Pima Indians

Diabetes ◽  
2004 ◽  
Vol 53 (10) ◽  
pp. 2696-2699 ◽  
Author(s):  
L. Ma ◽  
P. A. Tataranni ◽  
C. Bogardus ◽  
L. J. Baier
Keyword(s):  
Severe Obesity ◽  
Receptor Gene ◽  
Pima Indians ◽  
Gene Variation ◽  
Melanocortin 4 Receptor ◽  
Melanocortin 4 Receptor Gene

scholarly journals Association of melanocortin 4 receptor gene variation with satiation and gastric emptying in overweight and obese adults

2014 ◽  
Vol 9 (2) ◽  
Author(s):  
Andres Acosta ◽  
Michael Camilleri ◽  
Andrea Shin ◽  
Paula Carlson ◽  
Duane Burton ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Receptor Gene ◽  
Obese Adults ◽  
Gene Variation ◽  
Melanocortin 4 Receptor ◽  
Melanocortin 4 Receptor Gene

scholarly journals Eating behavior in patients with type 2 diabetes and melanocortin receptor gene polymorphism

2020 ◽  
Vol 4 (6) ◽  
pp. 318-323
Author(s):  
D.Sh. Avzaletdinova ◽  
◽  
T.V. Morugova ◽  
L.F. Sharipova ◽  
O.V. Kochetova ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Gene Polymorphism ◽  
Ethnic Group ◽  
Eating Behavior ◽  
Emotional Eating ◽  
Receptor Gene ◽  
Melanocortin Receptor ◽  
Allelic Variants ◽  
Mc4r Gene

Aim: to analyze the associations of rs17782313 polymorphism of melanocortin type 4 receptor (MC4R) gene in patients with type 2 diabetes (T2D) in Tatar ethnic group (Republic of Bashkortostan) and to determine the types of eating disorders in T2D patients and their association with MC4R allelic variants (rs17782313).Patients and Methods: MC4R rs17782313 gene polymorphism was genotyped by polymerase chain reaction (PCR) in 190 healthy individuals (39 men and 151 women, mean age 55.3±9.8 years) and 200 patients with T2D (57 men and 143 women, mean age 59.2±9.5 years). Eating behavior was assessed using the Dutch Eating Behaviour Questionnaire (DEBQ) in 134 controls and 83 patients with T2D. All individuals belonged to the Tatar ethnic group and lived in the Republic of Bashkortostan. Statistical analysis was performed using Statistica 6.0 and SNPStats software (https://www.snpstats.net/start.htm). Odds ratio (OR) was calculated using online platform (https://www.medcalc.org/calc/odds_ratio.php).Results: higher prevalence of C/C genotype of MC4R rs17782313 gene polymorphism was revealed in T2D patients compared to the controls (6.0% vs. 2.1%, respectively, p=0.0444). T2D patients were characterized by higher “Emotional eating” scores (р<0.00001) but lower “Restrictive eating” scores (р=0.0001) and “External eating” scores (р<0.0047) compared to healthy individuals. MC4R allelic variants (rs17782313) did not demonstrate any associations with eating behavior types in either T2D patients or controls. Conclusion: C/C genotype of rs17782313 MC4R gene polymorphism is a marker of higher risk of T2D in Tatar ethnic group (OR=2.9, p=0,0444). The mechanisms by which MC4R allelic variants (rs17782313) affect T2D pathogenesis require further studies.KEYWORDS: type 2 diabetes, eating behavior, Dutch Eating Behavior Questionnaire, DEBQ, melanocortin receptor type 4 gene, emotional eating, external eating, restrictive eating, genetic susceptibility, Tatar ethnic group.FOR CITATION: Avzaletdinova D.Sh., Morugova T.V., Sharipova L.F., Kochetova O.V. Eating behavior in patients with type 2 diabetes and melanocortin receptor gene polymorphism. Russian Medical Inquiry. 2020;4(6):318–323. DOI: 10.32364/2587-6821-2020-4-6-318-323.

Melanocortin-4 receptor gene variants are not associated with binge-eating behavior in nonobese patients with eating disorders

2015 ◽  
Vol 25 (1) ◽  
pp. 35-38 ◽  
Author(s):  
Carmen Gamero-Villarroel ◽  
Raquel Rodriguez-Lopez ◽  
Mercedes Jimenez ◽  
Juan A. Carrillo ◽  
Angustias Garcia-Herraiz ◽  
...  
Keyword(s):  
Eating Disorders ◽  
Binge Eating ◽  
Eating Behavior ◽  
Receptor Gene ◽  
Gene Variants ◽  
Melanocortin 4 Receptor ◽  
Melanocortin 4 Receptor Gene ◽  
Nonobese Patients

Analysis of variation in the melanocortin-4 receptor gene (mc4r) in golden retriever dogs

2010 ◽  
Vol 41 (5) ◽  
pp. 557-557 ◽  
Author(s):  
L. Van Den Berg ◽  
S. M. Van Den Berg ◽  
E. E. C. P. Martens ◽  
H. A. W. Hazewinkel ◽  
N. A. Dijkshoorn ◽  
...  
Keyword(s):  
Receptor Gene ◽  
Golden Retriever ◽  
Melanocortin 4 Receptor ◽  
Melanocortin 4 Receptor Gene ◽  
Analysis Of Variation
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