Effect of periodic vitamin A supplementation on mortality and morbidity of human immunodeficiency virus–infected children in Uganda: A controlled clinical trial

Nutrition ◽  
2005 ◽  
Vol 21 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Richard D. Semba ◽  
Christopher Ndugwa ◽  
Robert T. Perry ◽  
Tamara D. Clark ◽  
J. Brooks Jackson ◽  
...  
2002 ◽  
Vol 185 (8) ◽  
pp. 1187-1191 ◽  
Author(s):  
Jared M. Baeten ◽  
R. Scott McClelland ◽  
Julie Overbaugh ◽  
Barbra A. Richardson ◽  
Sandra Emery ◽  
...  

Author(s):  
Shakun Singh ◽  
Rachna Chaudhary ◽  
Vandana Dhama ◽  
Anu Singh ◽  
Urmila Karya

Background: To study the impact of Vitamin A supplementation in anaemia during Pregnancy and thus improving maternal and fetal outcome a Randomized double blind controlled clinical trial was conducted in Department of Obstetrics and Gynaecology, L.L.R.M. Medical college Meerut involving 250 pregnant women in late pregnancy 18-28 weeks with haemoglobin levels <11 g% (7-11 g%)..Methods: The study subjects were divided into two groups: Group A (n=125): Received daily supplement containing Iron (60 mg elemental iron) + Folate (500 mcg) + Vitamin A 20,000 IU weekly for a minimum of 12 weeks. Group B (n=125): Received daily supplement containing iron (60 mg elemental iron) + Folate (500 mcg) for a minimum of 12 weeks.Results: Maximum patients were uneducated belonging to low socioeconomic status. The mean haemoglobin values in Group A and Group B increased from 9.674±1.05 and 9.53±1.04 to 12.2±0.89 and 10.82±1.06 respectively after supplementation. Similarily Serum Ferritin levels increased from 15.96±2.94 and 15.70±2.83 to 78.40±17.82 and 58.64±11.93. Mean corpuscular volume, packed cell volume and red blood cell counts also increased significantly. Maximum haemoglobin levels were achieved with both vitamin A and iron supplementation. The proportion of women who became non anaemic was 97.17% in Group A vs 68.69% in Group B.Conclusions: Vitamin A supplementation improves anaemia and also dramatically improves iron stores in anaemic pregnant women.


1998 ◽  
Vol 177 (3) ◽  
pp. 611-616 ◽  
Author(s):  
Richard D. Semba ◽  
Cynthia M. Lyles ◽  
Joseph B. Margolick ◽  
Waleska T. Caiaffa ◽  
Homayoon Farzadegan ◽  
...  

2002 ◽  
Vol 35 (5) ◽  
pp. 618-624 ◽  
Author(s):  
Newton Kumwenda ◽  
Paolo G. Miotti ◽  
Taha E. Taha ◽  
Robin Broadhead ◽  
Robert J. Biggar ◽  
...  

1999 ◽  
Vol 58 (3) ◽  
pp. 719-727 ◽  
Author(s):  
R. D. Semba

Studies in animal models and cell lines show that vitamin A and related retinoids play a major role in immunity, including expression of mucins and keratins, lymphopoiesis, apoptosis, cytokine expression, production of antibody, and the function of neutrophils, natural killer cells, monocytes or macrophages, T lymphocytes and B lymphocytes. Recent clinical trials suggest that vitamin A supplementation reduces morbidity and mortality in different infectious diseases, such as measles, diarrhoeal disease, measles-related pneumonia, human immunodeficiency virus infection and malaria. Immune responses vary considerably during different infections, and the available data suggest that the modulation of immune function by vitamin A may also vary widely, depending on the type of infection and immune responses involved.


1999 ◽  
Vol 28 (4) ◽  
pp. 892-894 ◽  
Author(s):  
Velia A. Ramirez‐Amador ◽  
Lilly Esquivel‐Pedraza ◽  
Sergio Ponce‐de‐Leon ◽  
Gustavo Reyes‐Teran ◽  
Martha Gonzalez‐Guevara ◽  
...  

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