Improved risk assessment of coronary artery disease by substituting paraoxonase 1 activity for HDL-C: novel cardiometabolic biomarkers based on HDL functionality

2021 ◽  
Author(s):  
Abdolkarim Mahrooz ◽  
Yasaman Shokri ◽  
Atena Variji ◽  
Mehryar Zargari ◽  
Ahad Alizadeh ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Paraoxonase 1 ◽  
Hdl Functionality ◽  
Artery Disease

PP-209: PARAOXONASE 1 ENZYME ACTIVITY IN METABOLIC SYNDROME PATIENTS WITHOUT CORONARY ARTERY DISEASE

2011 ◽  
Vol 147 ◽  
pp. S148
Author(s):  
E. Yucel ◽  
A. Aydinlar ◽  
A. Aydin Kaderli ◽  
T. Senturk ◽  
S. Gunay ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Metabolic Syndrome ◽  
Enzyme Activity ◽  
Coronary Artery ◽  
Paraoxonase 1 ◽  
Artery Disease

Risk Assessment with Duke Treadmill Score in Patients with Coronary Artery Disease: Comparison with Scintigraphic and Angiographic Findings

2002 ◽  
Vol 32 (12) ◽  
pp. 1046
Author(s):  
Do Young Kang ◽  
Jaetae Lee ◽  
Sang Woo Lee ◽  
Shin Young Chung ◽  
Byeong Cheol Ahn ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Duke Treadmill Score ◽  
Artery Disease ◽  
Angiographic Findings

scholarly journals Aszimmetrikus dimetilarginin: a cardiovascularis betegségek prediktora?

2016 ◽  
Vol 157 (13) ◽  
pp. 483-487
Author(s):  
Balázs Németh ◽  
Péter Kustán ◽  
Ádám Németh ◽  
Zsófia Lenkey ◽  
Attila Cziráki ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Cardiovascular Diseases ◽  
Asymmetric Dimethylarginine ◽  
Disease Onset ◽  
Cardiovascular Prevention ◽  
Competitive Inhibitor ◽  
Diabetic Patients ◽  
Artery Disease

Cardiovascular diseases are the most common diseases worldwide. They are responsible for one third of global deaths and they are the leading cause of disability, too. The usage of different levels of prevention in combination with effective risk assessment improved these statistical data. Risk assessment based on classic risk factors has recently been supported with several new markers, such as asymmetric dimethylarginine, which is an endogenous competitive inhibitor of nitric oxide synthase. Elevated levels of asymmetric dimethylarginine have been reported in obese, smoker, hypercholesterolemic, hypertensive and diabetic patients. According to previous studies, asymmetric dimethylarginine is a suitable indicator of endothelial dysfunction, which is held to be the previous state of atherosclerosis. Several researches found positive correlation between higher levels of asymmetric dimethylarginine and coronary artery disease onset, or progression of existing coronary disease. According to a study involving 3000 patients, asymmetric dimethylarginine is an independent risk factor of cardiovascular mortality in patients with coronary artery disease. This article summarizes the role of asymmetric dimethylarginine in prediction of cardiovascular diseases, and underlines its importance in cardiovascular prevention. Orv. Hetil., 2016, 157(13), 483–487.

scholarly journals Relationship between rs854560PON1Gene Polymorphism and Tobacco Smoking with Coronary Artery Disease

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Joanna Iwanicka ◽  
Tomasz Iwanicki ◽  
Paweł Niemiec ◽  
Tomasz Nowak ◽  
Jolanta Krauze ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Cigarette Smoking ◽  
Relative Increase ◽  
Paraoxonase 1 ◽  
High Density Lipoproteins ◽  
Polish Population ◽  
Premature Cad ◽  
Traditional Risk Factors ◽  
Artery Disease

Paraoxonase-1 (PON1) is the antioxidant marker of high-density lipoproteins protecting against atherosclerosis and coronary artery disease (CAD) phenotype. The purpose of the present study was to determine whether thePON1gene rs854560 polymorphism (163T>A) is associated with CAD in Polish population. rs854560 was genotyped in 494 subjects: 248 patients with premature CAD and 246 blood donors as a control. We found that the risk of CAD was significantly higher in TT homozygotes than in A allele carriers (OR = 1.87,p=0.041). The synergistic effect between the TT genotype and cigarette smoking was observed (SIM = 9.81; SI = 14.70). The relative increase in risk from interaction between factors was over 37 (RERI = 36.13). ThePON1polymorphism did not modulate the risk of CAD in response to exposure to other traditional risk factors. In conclusion, the rs854560 polymorphism may modulate the risk of CAD in response to cigarette smoking in Polish population. Carriers of TT genotype seem to be particularly at risk of CAD, when exposed to cigarette smoking.

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