scholarly journals Paraoxonase 1 gene (Q192R) polymorphism confers susceptibility to coronary artery disease in type 2 diabetes patients: Evidence from case-control studies

2019 ◽  
Vol 13 (2) ◽  
pp. 80-88 ◽  
Author(s):  
Xiaowei Huo ◽  
Yuan Guo ◽  
Yongjian Zhang ◽  
Jieqiong Li ◽  
Xiulin Wen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Case Control ◽  
Paraoxonase 1 ◽  
Case Control Studies ◽  
Q192r Polymorphism ◽  
Artery Disease ◽  
Diabetes Patients

scholarly journals Coronary artery disease risk in Chinese type 2 diabetics: is there a role for paraxonase 1 gene (Q192R) polymorphism?

2001 ◽  
pp. 639-644 ◽  
Author(s):  
D Osei-Hyiaman ◽  
L Hou ◽  
F Mengbai ◽  
R Zhiyin ◽  
Z Zhiming ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Central China ◽  
Paraoxonase 1 ◽  
Control Subjects ◽  
Q192r Polymorphism ◽  
Type 2 Diabetics ◽  
Artery Disease

OBJECTIVE: Heredity plays an important role in the predisposition to atherosclerotic coronary artery disease (CAD), and its thrombotic complications. Paraoxonase, a high-density lipoprotein-associated enzyme capable of hydrolyzing lipid peroxides, is presumed to contribute to atherosclerosis and CAD. This study investigates the role of human paraoxonase 1 (PON 1) gene (Q192R) polymorphism in CAD risk among Chinese type 2 diabetic cases. DESIGN: A population-based case-control study of paraoxonase 1 gene (Q192R) polymorphism and the risk of CAD in Chinese type 2 diabetics. METHODS: Subjects included 201 angiographically documented CAD patients with type 2 diabetes and 231 control subjects with type 2 diabetes alone living in central China. Single strand conformational polymorphism (SSCP) analysis was used to screen for PON 1 gene (Q192R) polymorphism. RESULTS: Frequency of the R allele was 21.5% in the CAD patients and 12.0% in the control subjects. The presence of the R allele was significantly associated with risk of CAD (odds ratio (OR)=1.97; 95% confidence interval (CI)=1.36--2.86). CONCLUSION: Frequency of the 192R allele of the human paraoxonase 1 gene may be an independent risk factor for CAD in the Chinese type 2 diabetics studied.

scholarly journals Platelet Mediated Inflammation in Coronary Artery Disease with Type 2 Diabetes Patients

2021 ◽  
Vol Volume 14 ◽  
pp. 5131-5147
Author(s):  
Ebin Johny ◽  
Pathoori Bhaskar ◽  
Md Jahangir Alam ◽  
Indra Kuladhipati ◽  
Rupam Das ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Artery Disease ◽  
Diabetes Patients

scholarly journals Paraoxonase 1 gene (Gln192–Arg) polymorphism and the risk of coronary artery disease in type 2 diabetes mellitus

2012 ◽  
Vol 64 (2) ◽  
pp. 55-62 ◽  
Author(s):  
Mohamed Fahmy Elnoamany ◽  
Ashraf Abdelraouf Dawood ◽  
Rania Mohamed Azmy ◽  
Mostafa Mohamed Elnajjar
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Coronary Artery Disease ◽  
Type 2 Diabetes Mellitus ◽  
Coronary Artery ◽  
Paraoxonase 1 ◽  
Artery Disease
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