A comparison of gamma-glutamyl transferase and alkaline phosphatase as prognostic markers in patients with coronary heart disease

2018 ◽  
Vol 28 (1) ◽  
pp. 64-70 ◽  
Author(s):  
G. Ndrepepa ◽  
S. Holdenrieder ◽  
S. Cassese ◽  
M. Fusaro ◽  
E. Xhepa ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Alkaline Phosphatase ◽  
Heart Disease ◽  
Prognostic Markers ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase

scholarly journals DIFFERENCES OF GAMMA GLUTAMYL TRANSFERASE IN CORONARY HEART DISEASE PATIENTS WITH MORE THAN EQUAL 70% OCCLUSION AND LESS THAN 70% OCCLUSION

2020 ◽  
pp. 1-3
Author(s):  
Dahlan Siahaan ◽  
Burhanuddin Nasution ◽  
Nizam Zikri Akbar
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Causes Of Death ◽  
Gamma Glutamyl Transferase ◽  
Cross Sectional ◽  
Heart Attacks ◽  
Gamma Glutamyl ◽  
Artery Disease ◽  
Glutamyl Transferase ◽  
Relationship Of

Background: Coronary heart disease (CHD) is a cumulation of plaque in the heart arteries that can cause heart attacks. CHD is one of the main and rst causes of death in developed and developing countries, including Indonesia. It is estimated that throughout the world, CHD in 2020 became the rst most frequent killer of 36% of all deaths, twice as high as cancer deaths. Currently Gamma Glutamyl Transferase (GGT) is a prognostic marker of death and reinfarction in patients with patients Coronary Artery Disease (CAD) and there is a relationship of GGT with the prognosis of CAD patients undergoing angiography. Methods: The study was conducted by cross sectional method. The study subjects were 60 male and female CHD patients who were treated and treated at the hospital in the Department of Cardiology FK-USU / H. Adam Malik Hospital Medan, which was enforced by history, physical examination, angiography and laboratory and underwent coronary angiography. GGT examination uses Architect c8000. Results: A total of 60 CHD patients in this study found that GGT values were greater in the ≥70% group compared with occlusions <70% with p = 0.003. Conclusions: This study showed a signicant difference in the values of GGT with occlusion ≥70% and <70% occlusion.

Gamma‐glutamyl transferase and cardiovascular events in patients with congenital heart disease

2021 ◽  
Author(s):  
Efrén Martínez‐Quintana ◽  
Javier Pardo‐Maiza ◽  
Beatriz Déniz‐Alvarado ◽  
Marta Riaño‐Ruiz ◽  
Jesús María González‐Martín ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Cardiovascular Events ◽  
Congenital Heart ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase

scholarly journals Comparative Study of Serum Gamma Glutamyltransferase, 5’ Nucleotidase and Alkaline Phosphatase in Icteric and an-Icteric Biliary Disease Patients

2013 ◽  
Vol 12 (1) ◽  
Author(s):  
Dr. Maninder Pal Singh Gill
Keyword(s):  
Alkaline Phosphatase ◽  
Significant Rise ◽  
Control Group ◽  
P Value ◽  
Gamma Glutamyl Transferase ◽  
Biliary Disease ◽  
Gamma Glutamyl ◽  
Hepatobiliary Diseases ◽  
Glutamyl Transferase ◽  
Diagnostic Indicator

Introduction: Diagnostic enzymology plays a useful role in evaluation of various hepatobiliary diseases and numerous enzymes have been compared in different disorders. Among these, significance of Gamma Glutamyl Transferase and 5’ Nucleotidase over Alkaline Phosphatase has been stressed repeatedly, but mainly in the icteric obstructive biliary disease patients. In this study, these three enzymes were compared not only in the icteric but also the an-icteric biliary disease patients, particularly to look for elevation and significance of these enzymes in the latter group.Methods: The study was conducted on 50 biliary disease patients, who were further divided into an-icteric (32 patients) and icteric (18 patients) subgroups depending on their bilirubin levels. 50 subjects matched for age and sex with the study group were enrolled for the control group. Gamma Glutamyl Transferase, 5’Nucleotidase, Alkaline Phosphatase and bilirubin levels were evaluated in all the patients as well as the control subjects. Results: All three enzymes showed a significant rise in the icteric subgroup (p value < 0.001). However, in the an-icteric subgroup, only Gamma Glutamyl Transferase and 5’Nucleotidase showed a significant rise. The rise was more for Gamma Glutamyl Transferse (1.60 times normal, p < 0.001) as compared to 5’Nucleotidase (1.39 times normal, p < 0.01). Conclusion: Gamma Glutamyl Transferase and 5’Nucleotidase are useful for evaluation of not only obstructive biliary disease patients but also for the patients with biliary disease who are an-icteric, and out of these two, the former is a more valuable diagnostic indicator in such diseases

scholarly journals Studies on the subcellular localization of human neutrophil alkaline phosphatase

1979 ◽  
Vol 36 (1) ◽  
pp. 401-412
Author(s):  
G.J. Rustin ◽  
P.D. Wilson ◽  
T.J. Peters
Keyword(s):  
Alkaline Phosphatase ◽  
Endoplasmic Reticulum ◽  
Density Gradient ◽  
Human Neutrophil ◽  
Density Gradient Centrifugation ◽  
Gradient Centrifugation ◽  
Human Neutrophils ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase

The intracellular localization of alkaline phosphatase has been determined in human neutrophils with analytical subcellular fractionation by density gradient centrifugation and EM cytochemistry. Centrifugation on sucrose gradients containing 1 mM DETA and 5 units/ml of heparin showed that alkaline phosphatase was associated with a membranous component distinct from plasma membrane, mitochondria, specific granules and azurophil granules. There was no resolution from the endoplasmic reticulum. Density gradient centrifugation on a sucrose-imidazole-heparin gradient showed a clear resolution of the alkaline phosphatase-containing membranes from the Golgi and endoplasmic reticulum. Density gradient centrifugation of neutrophils that had been disrupted in the presenceof 0.12 mmol/l. digitonin clearly separated alkaline phosphatase-containing membranes from the endoplasmic reticulum. Part of the gamma-glutamyl transferase has a similar localization to that of alkaline phosphatase. EM cytochemistry of neutrophils, neutrophil homogenates and of the density gradient fractions identified alkaline phosphatase-containing granules as irregular-shaped, often tubular, structures. It is suggested that alkaline phosphatase and part of the gamma-glutamyl transferase activity are localized to a unique organelle in the human neutrophil.

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