Gamma‐glutamyl transferase and cardiovascular events in patients with congenital heart disease

2021 ◽  
Author(s):  
Efrén Martínez‐Quintana ◽  
Javier Pardo‐Maiza ◽  
Beatriz Déniz‐Alvarado ◽  
Marta Riaño‐Ruiz ◽  
Jesús María González‐Martín ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Cardiovascular Events ◽  
Congenital Heart ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase

scholarly journals P1582 Outcomes, predictors and treatment of intraatrial reentrant tachycardias in Adult with Congenital Heart Disease

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
E Cambronero Cortinas ◽  
P Moratalla-Haro ◽  
A E Gonzalez-Garcia ◽  
P Avila-Alonso ◽  
M Bret-Zurita ◽  
...  
Keyword(s):  
Risk Factors ◽  
Congenital Heart Disease ◽  
Risk Factor ◽  
Heart Disease ◽  
Tricuspid Regurgitation ◽  
Cardiovascular Events ◽  
Congenital Heart ◽  
Late Complication ◽  
Systolic Pressure ◽  
First Choice

Abstract Introduction and objectives Atrial tachycardia (AT) is a major late complication in congenital heart disease (CHD) after surgery. These arrhythmias arise between areas of anatomical barriers or in fibrotic tissue/scars. In our study we examined the clinical predictors of AT. Methods A retrospective study of cases and controls in adult patients with CHD was performed. We have included consecutively 71 patients with AT and 71 controls matched by gender, age and type of CHD located in the same database. Medical records, electrocardiograms and echocardiograms were reviewed. Multivariate analysis of the risk factor (logistic regression) and analysis of adverse cardiovascular events (Kaplan-Meier) were performed. Results Systolic pressure of subpulmonary ventricle ≥40mmHg (HR:7, 95%CI:2.4-18, p = 0.001), right atrium (RA) dilatation≥21cm2 (HR:3, 95%CI:1.2-7.6, p = 0.005), significant tricuspid regurgitation (HR:4, 95%CI:1.3-10, p = 0.018) were identified as main risk factors for AT. Patients with AT had worse outcomes with more major adverse cardiovascular events (86% vs 14%, P = 0.006), and a 58% free survival events compared to 98% of patients without AT at 8 years of follow-up (p = 0.01). The treatment of the first episode of AT was electrical cardioversion (38%), pharmacological cardioversion (13%), heart rate control (20%). Antiarrhythmic treatment was not been given in 30% of the patients 73% of them had percutaneous ablation as first choice treatment. Ablation was performed in 40 pacientes and 6 patients have recurrences. In total, 24 patients have recurrences of AT. Previous Maze (OR 9 (IC al 95% 1.5, 50), p = 0.016) and surgical paliative shunt (OR 21 (IC al 95% 2.3,192), p = 0.007) were identified as main risk factor for AT recurrences. Conclusions The main risk factors identified for AT were RA dilatation, raised systolic pressure of subpulmonary ventricle and significant tricuspid regurgitation. The main risk factors for AT recurrences were previous Maze and surgical paliative shunt. Early treatment of these arrhythmic problems is mandatory in order to improve the prognosis in this group of patients. Abstract P1582 Figure. Central illustration of AT in CHD

Relation of Gamma-Glutamyl Transferase to Cardiovascular Events in Patients With Acute Coronary Syndromes

2016 ◽  
Vol 117 (9) ◽  
pp. 1427-1432 ◽  
Author(s):  
Gjin Ndrepepa ◽  
Siegmund Braun ◽  
Salvatore Cassese ◽  
Massimiliano Fusaro ◽  
Karl-Ludwig Laugwitz ◽  
...  
Keyword(s):  
Acute Coronary Syndromes ◽  
Cardiovascular Events ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Coronary Syndromes ◽  
Glutamyl Transferase

scholarly journals Global Longitudinal Strain of the Systemic Ventricle Is Correlated with Plasma Galectin-3 and Predicts Major Cardiovascular Events in Adult Patients with Congenital Heart Disease

Medicina ◽  
2020 ◽  
Vol 56 (6) ◽  
pp. 305
Author(s):  
Alexandra A. Frogoudaki ◽  
Ioannis Pantelakis ◽  
Vasiliki Bistola ◽  
Christos Kroupis ◽  
Dionysia Birba ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Cardiovascular Events ◽  
Congenital Heart ◽  
Longitudinal Strain ◽  
Heart Diseases ◽  
Adult Congenital Heart Disease ◽  
Global Longitudinal Strain ◽  
Major Cardiovascular Events ◽  
Galectin 3

Backround and Objective: We sought to assess in adult congenital heart disease (ACHD) patients the prognostic value of plasma galectin-3 (Gal-3) levels and systemic ventricular global longitudinal strain (SV GLS) as well as their association with NTproBNP and arrhythmogenesis. Materials and Methods: We studied 58 patients (26 men, mean age 37 ± 16.8 years) with various congenital heart diseases. Patients underwent echocardiogram, 24 h ambulatory ECG monitoring, while NTproBNP and Gal-3 were measured. They were followed up (median of 790.5 days -IQR 350.3 days) and major cardiovascular events (MACE) were recorded. Results. Mean Gal-3 levels were 17.07 ± 6.38 ng/m. Plasma Gal-3 was correlated with LogNTproBNP (r = 0.456, p = 0.001).Gal-3 levels associated with supraventricular tachycardia (SVT) (p < 0.001) and ventricular tachycardia (VT) (p < 0.001), but was not associated with MACE (HR 1.018, 95% CI 0.944–1.098, p = 0.641).Mean SVGLS in patients with systemic left ventricle was −15.91% ± 4.09%, which was significantly lower compared to patients with systemic right ventricle and patients with single ventricle (−11.42% ± 3.37% and −11.9% ± 5.06%, respectively, p = 0.021).SV GLS correlated with plasma Gal-3 (r = 0.313, p = 0.027) and logNTproBNP (r = 0.479, p < 0.001). SVGLS correlated with VT arrhythmias (p = 0.004). NTproBNP predicted MACE (AUC 0.750, p = 0.03). SVGLS also predicted MACE (AUC 0.745, p = 0.03. In multivariate analysis, SVGLS and logNTproBNP maintained their predictive value (p = 0.004 and p = 0.009, respectively) Conclusion: In ACHD patients, SV GLS was found to predict MACE independently from NTproBNP and correlated with VT. Gal-3 correlated with NTproBNP and SVGLS as well as SVT and VT, but has not been shown to bear significant prognostic potential.

PREDICTORS OF LONG-TERM MATERNAL CARDIOVASCULAR EVENTS AMONG WOMEN WITH CONGENITAL HEART DISEASE

2020 ◽  
Vol 75 (11) ◽  
pp. 604
Author(s):  
Hayley Schultz ◽  
Nasim C. Sobhani ◽  
Sarah Blissett ◽  
Juan M Gonzalez Velez ◽  
Ian Stewart Harris ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Cardiovascular Events ◽  
Congenital Heart

scholarly journals P4530Red blood cell distribution width predicts cardiovascular events in adults with congenital heart disease

2017 ◽  
Vol 38 (suppl_1) ◽  
Author(s):  
V.J.M. Baggen ◽  
A.E. Van Den Bosch ◽  
M. Witsenburg ◽  
J.A.A.E. Cuypers ◽  
E. Boersma ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Blood Cell ◽  
Cardiovascular Events ◽  
Congenital Heart ◽  
Cell Distribution ◽  
Distribution Width
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