Maternal low-protein diet induces changes in the cardiovascular autonomic modulation in male rat offspring

2015 ◽  
Vol 25 (1) ◽  
pp. 123-130 ◽  
Author(s):  
M.A.V. Barros ◽  
J.L. De Brito Alves ◽  
V.O. Nogueira ◽  
A.G. Wanderley ◽  
J.H. Costa-Silva
Keyword(s):  
Protein Diet ◽  
Low Protein Diet ◽  
Male Rat ◽  
Autonomic Modulation ◽  
Rat Offspring ◽  
Low Protein

Paternal line multigenerational passage of altered risk assessment behavior in female but not male rat offspring of mothers fed a low protein diet

2015 ◽  
Vol 140 ◽  
pp. 89-95 ◽  
Author(s):  
L.A. Reyes-Castro ◽  
G.L. Rodríguez-González ◽  
R. Chavira ◽  
C. Ibáñez ◽  
C. Lomas-Soria ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Male Rat ◽  
Rat Offspring ◽  
Low Protein ◽  
Paternal Line

Cholinergic-pathway-weakness-associated pancreatic islet dysfunction: a low-protein-diet imprint effect on weaned rat offspring

2020 ◽  
Vol 11 (5) ◽  
pp. 484-491 ◽  
Author(s):  
Paulo Cezar de Freitas Mathias ◽  
Ginislene Dias Souza Miranda ◽  
Luiz Felipe Barella ◽  
Rosiane Aparecida Miranda ◽  
Audrei Pavanello ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Pancreatic Islet ◽  
Muscarinic Acetylcholine Receptor ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Suckling Period ◽  
Rat Offspring ◽  
Low Protein ◽  
Muscarinic Response ◽  
Insulin Homeostasis

AbstractCurrently, metabolic disorders are one of the major health problems worldwide, which have been shown to be related to perinatal nutritional insults, and the autonomic nervous system and endocrine pancreas are pivotal targets of the malprogramming of metabolic function. We aimed to assess glucose–insulin homeostasis and the involvement of cholinergic responsiveness (vagus nerve activity and insulinotropic muscarinic response) in pancreatic islet capacity to secrete insulin in weaned rat offspring whose mothers were undernourished in the first 2 weeks of the suckling phase. At delivery, dams were fed a low-protein (4% protein, LP group) or a normal-protein diet (20.5% protein, NP group) during the first 2 weeks of the suckling period. Litter size was adjusted to six pups per mother, and rats were weaned at 21 days old. Weaned LP rats presented a lean phenotype (P < 0.01); hypoglycaemia, hypoinsulinaemia and hypoleptinaemia (P < 0.05); and normal corticosteronaemia (P > 0.05). In addition, milk insulin levels in mothers of the LP rats were twofold higher than those of mothers of the NP rats (P < 0.001). Regarding glucose–insulin homeostasis, weaned LP rats were glucose-intolerant (P < 0.01) and displayed impaired pancreatic islet insulinotropic function (P < 0.05). The M3 subtype of the muscarinic acetylcholine receptor (M3mAChR) from weaned LP rats was less responsive, and the superior vagus nerve electrical activity was reduced by 30% (P < 0.01). A low-protein diet in the suckling period malprogrammes the vagus nerve to low tonus and impairs muscarinic response in the pancreatic β-cells of weaned rats, which are imprinted to secrete inadequate insulin amounts from an early age.

Perinatal free‐choice of a high‐calorie low‐protein diet affects leptin signaling through IRS1 and AMPK dephosphorylation in the hypothalami of female rat offspring in adulthood

2019 ◽  
Vol 226 (2) ◽  
pp. e13244 ◽  
Author(s):  
Patricia Rivera ◽  
María T. Ramírez‐López ◽  
Antonio Vargas ◽  
Juan Decara ◽  
Mariam Vázquez ◽  
...  
Keyword(s):  
Free Choice ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Female Rat ◽  
Leptin Signaling ◽  
Rat Offspring ◽  
Low Protein ◽  
High Calorie

Hitting a triple in the non-alcoholic fatty liver disease field: sucrose intake in adulthood increases fat content in the female but not in the male rat offspring of dams fed a gestational low-protein diet

2017 ◽  
Vol 9 (2) ◽  
pp. 151-159 ◽  
Author(s):  
L. Nicolás-Toledo ◽  
M. Cervantes-Rodríguez ◽  
E. Cuevas-Romero ◽  
D. L. Corona-Quintanilla ◽  
E. Pérez-Sánchez ◽  
...  
Keyword(s):  
Maternal Diet ◽  
Fat Content ◽  
Protein Diet ◽  
Liver Fat ◽  
Low Protein Diet ◽  
Male Rat ◽  
Liver Fat Content ◽  
Alcoholic Fatty Liver ◽  
Low Protein ◽  
Alcoholic Fatty Liver Disease

The excessive consumption of carbohydrates is related to non-alcoholic fatty liver disease (NAFLD) in infants and adults. The effect of combining maternal malnutrition and a high carbohydrate intake on the development of NAFLD in adulthood remains unknown. We therefore hypothesized that consumption of 5% sucrose by the offspring of dams fed a low-protein diet during pregnancy promotes liver fat accumulation and oxidative damage differently in females and males. To test this, 12-month-old female and male offspring of mothers fed a Control (C) or low-protein diet (Restricted, R) were provided with either tap water or 5% sucrose for a period of 10 weeks. Livers were excised to measure the fat content and 3-nitrotyrosine (3-NTyr) immunostaining; serum samples were also obtained to measure the concentration of malondialdehyde (MDA). Data were analyzed using a non-repeated measures three-way analysis of variance to determine significant differences (P<0.05) regarding to the interaction among maternal diet, sucrose consumption and sex. Results showed that the liver fat content of females from R mothers was higher than that of their male counterpart. Hepatic 3-NTyr immunostaining and serum MDA concentrations were not affected by the interaction involving maternal diet, sucrose consumption and sex. Otherwise, liver fat content was correlated with the hepatic 3-NTyr immunostaining and serum MDA concentrations only in females. Thus, sucrose intake in adulthood increases fat content in the female but not in the male rat offspring of dams fed with a low-protein diet during pregnancy. This research emphasizes the importance of a balanced diet during pregnancy and the influence of the diet on the adult offspring.

Early renal structure alteration in rat offspring from dams fed low protein diet

Life Sciences ◽  
2006 ◽  
Vol 79 (22) ◽  
pp. 2128-2134 ◽  
Author(s):  
Karla Maria Pereira Pires ◽  
Marcia Barbosa Aguila ◽  
Carlos Alberto Mandarim-de-Lacerda
Keyword(s):  
Protein Diet ◽  
Low Protein Diet ◽  
Rat Offspring ◽  
Low Protein ◽  
Renal Structure

Maternal Low-Protein Diet Impairs Prostate Growth in Young Rat Offspring and Induces Prostate Carcinogenesis With Aging

2018 ◽  
Vol 74 (6) ◽  
pp. 751-759 ◽  
Author(s):  
Sergio A A Santos ◽  
Ana C Camargo ◽  
Flávia B Constantino ◽  
Ketlin T Colombelli ◽  
Fernanda Mani ◽  
...  
Keyword(s):  
Protein Diet ◽  
Low Protein Diet ◽  
Rat Offspring ◽  
Prostate Carcinogenesis ◽  
Low Protein ◽  
Young Rat ◽  
Prostate Growth
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