Perinatal free‐choice of a high‐calorie low‐protein diet affects leptin signaling through IRS1 and AMPK dephosphorylation in the hypothalami of female rat offspring in adulthood

2019 ◽  
Vol 226 (2) ◽  
pp. e13244 ◽  
Author(s):  
Patricia Rivera ◽  
María T. Ramírez‐López ◽  
Antonio Vargas ◽  
Juan Decara ◽  
Mariam Vázquez ◽  
...  
Keyword(s):  
Free Choice ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Female Rat ◽  
Leptin Signaling ◽  
Rat Offspring ◽  
Low Protein ◽  
High Calorie

Cholinergic-pathway-weakness-associated pancreatic islet dysfunction: a low-protein-diet imprint effect on weaned rat offspring

2020 ◽  
Vol 11 (5) ◽  
pp. 484-491 ◽  
Author(s):  
Paulo Cezar de Freitas Mathias ◽  
Ginislene Dias Souza Miranda ◽  
Luiz Felipe Barella ◽  
Rosiane Aparecida Miranda ◽  
Audrei Pavanello ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Pancreatic Islet ◽  
Muscarinic Acetylcholine Receptor ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Suckling Period ◽  
Rat Offspring ◽  
Low Protein ◽  
Muscarinic Response ◽  
Insulin Homeostasis

AbstractCurrently, metabolic disorders are one of the major health problems worldwide, which have been shown to be related to perinatal nutritional insults, and the autonomic nervous system and endocrine pancreas are pivotal targets of the malprogramming of metabolic function. We aimed to assess glucose–insulin homeostasis and the involvement of cholinergic responsiveness (vagus nerve activity and insulinotropic muscarinic response) in pancreatic islet capacity to secrete insulin in weaned rat offspring whose mothers were undernourished in the first 2 weeks of the suckling phase. At delivery, dams were fed a low-protein (4% protein, LP group) or a normal-protein diet (20.5% protein, NP group) during the first 2 weeks of the suckling period. Litter size was adjusted to six pups per mother, and rats were weaned at 21 days old. Weaned LP rats presented a lean phenotype (P < 0.01); hypoglycaemia, hypoinsulinaemia and hypoleptinaemia (P < 0.05); and normal corticosteronaemia (P > 0.05). In addition, milk insulin levels in mothers of the LP rats were twofold higher than those of mothers of the NP rats (P < 0.001). Regarding glucose–insulin homeostasis, weaned LP rats were glucose-intolerant (P < 0.01) and displayed impaired pancreatic islet insulinotropic function (P < 0.05). The M3 subtype of the muscarinic acetylcholine receptor (M3mAChR) from weaned LP rats was less responsive, and the superior vagus nerve electrical activity was reduced by 30% (P < 0.01). A low-protein diet in the suckling period malprogrammes the vagus nerve to low tonus and impairs muscarinic response in the pancreatic β-cells of weaned rats, which are imprinted to secrete inadequate insulin amounts from an early age.

Paternal line multigenerational passage of altered risk assessment behavior in female but not male rat offspring of mothers fed a low protein diet

2015 ◽  
Vol 140 ◽  
pp. 89-95 ◽  
Author(s):  
L.A. Reyes-Castro ◽  
G.L. Rodríguez-González ◽  
R. Chavira ◽  
C. Ibáñez ◽  
C. Lomas-Soria ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Male Rat ◽  
Rat Offspring ◽  
Low Protein ◽  
Paternal Line

Early renal structure alteration in rat offspring from dams fed low protein diet

Life Sciences ◽  
2006 ◽  
Vol 79 (22) ◽  
pp. 2128-2134 ◽  
Author(s):  
Karla Maria Pereira Pires ◽  
Marcia Barbosa Aguila ◽  
Carlos Alberto Mandarim-de-Lacerda
Keyword(s):  
Protein Diet ◽  
Low Protein Diet ◽  
Rat Offspring ◽  
Low Protein ◽  
Renal Structure

Maternal Low-Protein Diet Impairs Prostate Growth in Young Rat Offspring and Induces Prostate Carcinogenesis With Aging

2018 ◽  
Vol 74 (6) ◽  
pp. 751-759 ◽  
Author(s):  
Sergio A A Santos ◽  
Ana C Camargo ◽  
Flávia B Constantino ◽  
Ketlin T Colombelli ◽  
Fernanda Mani ◽  
...  
Keyword(s):  
Protein Diet ◽  
Low Protein Diet ◽  
Rat Offspring ◽  
Prostate Carcinogenesis ◽  
Low Protein ◽  
Young Rat ◽  
Prostate Growth

A low-protein diet concomitant with high calorie intake preserves renal function and structure in diabetic OLETF rats

2004 ◽  
Vol 8 (4) ◽  
pp. 322-330 ◽  
Author(s):  
Sanae Matsuda ◽  
Kazuko Iwata ◽  
Kazushi Takahashi ◽  
Hitoshi Homma ◽  
Yoshifuru Tamura ◽  
...  
Keyword(s):  
Renal Function ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Calorie Intake ◽  
Oletf Rats ◽  
Low Protein ◽  
High Calorie
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