Plasma phospholipid fatty acid composition as a biomarker of habitual dietary fat intake in an ethnically diverse cohort

2007 ◽  
Vol 17 (6) ◽  
pp. 415-426 ◽  
Author(s):  
Allison M. Hodge ◽  
Julie A. Simpson ◽  
Robert A. Gibson ◽  
Andrew J. Sinclair ◽  
Maria Makrides ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Dietary Fat ◽  
Phospholipid Fatty Acid ◽  
Ethnically Diverse ◽  
Plasma Phospholipid ◽  
Phospholipid Fatty Acid Composition ◽  
Fat Intake ◽  
Plasma Phospholipid Fatty Acid

scholarly journals Effect of Sex Hormones on Plasma Phospholipid Fatty Acid Composition in Intact Rats and Rats With Bilaterally Occluded Carotid Arteries

2014 ◽  
pp. 331-339
Author(s):  
S. PETROVIĆ ◽  
M. TAKIĆ ◽  
A. ARSIĆ ◽  
V. VUČIĆ ◽  
D. DRAKULIĆ ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Carotid Arteries ◽  
Plasma Lipids ◽  
Phospholipid Fatty Acid ◽  
Plasma Phospholipid ◽  
Phospholipid Fatty Acid Composition ◽  
Estradiol Treatment ◽  
Total N

The effects of 8-days treatment with 17α-estradiol (33.3 µg/kg) and progesterone (1.7 mg/kg) on plasma lipids and fatty acid composition of plasma phospholipids were examined in intact (INT) and bilaterally common carotid arteries occluded (BCO) male Wistar rats. Significant decrease of triglyceride level was found in BCO rats after the estradiol treatment. Both hormones elevated proportion of 18:1n-7 fatty acid in INT, but they failed to have such an effect in BCO. Estradiol increased 22:5n-3 and total n-3 polyunsaturated fatty acids (PUFA) in intact, and decreased 18:2n-6 in BCO rats. Significantly lower level of total n-3 was found in progesterone-treated than in estradiol-treated BCO rats. Given that n-3 PUFA have many beneficial effects on cell and tissue function, while n-6 PUFA have mostly the opposite effects, estradiol, rather than progesterone, was seen to improve plasma lipids and phospholipids FA profiles in INT and BCO animals. Estradiol significantly elevated the estimated activity of Δ9-desaturases and progesterone of Δ5-desaturase in BCO group, with no effects in INT rats.

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