Cytotoxicity, cellular uptake, and subcellular localization of a nitrogen oxide and aminopropyl-β-lactose derivative ruthenium complex used as nitric oxide delivery agent

Nitric Oxide ◽  
2019 ◽  
Vol 86 ◽  
pp. 38-47 ◽  
Author(s):  
Joicy Santamalvina dos Santos ◽  
Loyanne C. Ramos ◽  
Lucimara P. Ferreira ◽  
Vanessa Leira Campo ◽  
Lucas C.D. de Rezende ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Subcellular Localization ◽  
Nitrogen Oxide ◽  
Cellular Uptake ◽  
Ruthenium Complex ◽  
Nitric Oxide Delivery

Nitrosyl ruthenium complex as nitric oxide delivery agent: synthesis, characterization and photochemical properties

2004 ◽  
Vol 7 (2) ◽  
pp. 160-164 ◽  
Author(s):  
Fabiana de Souza Oliveira ◽  
Vanessa Togniolo ◽  
Thais T Pupo ◽  
Antonio Claudio Tedesco ◽  
Roberto Santana da Silva
Keyword(s):  
Nitric Oxide ◽  
Ruthenium Complex ◽  
Photochemical Properties ◽  
Nitric Oxide Delivery

scholarly journals Nitroaromatic Antibiotics as Nitrogen Oxide Sources

Biomolecules ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 267
Author(s):  
Allison M. Rice ◽  
Yueming Long ◽  
S. Bruce King
Keyword(s):  
Nitric Oxide ◽  
Nitrogen Oxide ◽  
Reactive Nitrogen Species ◽  
Human African Trypanosomiasis ◽  
Anaerobic Bacteria ◽  
Mechanisms Of Action ◽  
Disease Treatment ◽  
Therapeutic Development ◽  
New Treatments ◽  
Reductive Metabolism

Nitroaromatic antibiotics show activity against anaerobic bacteria and parasites, finding use in the treatment of Heliobacter pylori infections, tuberculosis, trichomoniasis, human African trypanosomiasis, Chagas disease and leishmaniasis. Despite this activity and a clear need for the development of new treatments for these conditions, the associated toxicity and lack of clear mechanisms of action have limited their therapeutic development. Nitroaromatic antibiotics require reductive bioactivation for activity and this reductive metabolism can convert the nitro group to nitric oxide (NO) or a related reactive nitrogen species (RNS). As nitric oxide plays important roles in the defensive immune response to bacterial infection through both signaling and redox-mediated pathways, defining controlled NO generation pathways from these antibiotics would allow the design of new therapeutics. This review focuses on the release of nitrogen oxide species from various nitroaromatic antibiotics to portend the increased ability for these compounds to positively impact infectious disease treatment.

scholarly journals Ruthenium-based PACT agents based on bisquinoline chelates: synthesis, photochemistry, and cytotoxicity

2021 ◽  
Author(s):  
Anja Busemann ◽  
Ingrid Flaspohler ◽  
Xue-Quan Zhou ◽  
Claudia Schmidt ◽  
Sina K. Goetzfried ◽  
...  
Keyword(s):  
Quantum Yield ◽  
Singlet Oxygen ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Ruthenium Complex ◽  
Human Cancer ◽  
Light Irradiation ◽  
Quantum Yields ◽  
Light Activation ◽  
Human Cancer Cells

AbstractThe known ruthenium complex [Ru(tpy)(bpy)(Hmte)](PF6)2 ([1](PF6)2, where tpy = 2,2’:6’,2″-terpyridine, bpy = 2,2’-bipyridine, Hmte = 2-(methylthio)ethanol) is photosubstitutionally active but non-toxic to cancer cells even upon light irradiation. In this work, the two analogs complexes [Ru(tpy)(NN)(Hmte)](PF6)2, where NN = 3,3'-biisoquinoline (i-biq, [2](PF6)2) and di(isoquinolin-3-yl)amine (i-Hdiqa, [3](PF6)2), were synthesized and their photochemistry and phototoxicity evaluated to assess their suitability as photoactivated chemotherapy (PACT) agents. The increase of the aromatic surface of [2](PF6)2 and [3](PF6)2, compared to [1](PF6)2, leads to higher lipophilicity and higher cellular uptake for the former complexes. Such improved uptake is directly correlated to the cytotoxicity of these compounds in the dark: while [2](PF6)2 and [3](PF6)2 showed low EC50 values in human cancer cells, [1](PF6)2 is not cytotoxic due to poor cellular uptake. While stable in the dark, all complexes substituted the protecting thioether ligand upon light irradiation (520 nm), with the highest photosubstitution quantum yield found for [3](PF6)2 (Φ[3] = 0.070). Compounds [2](PF6)2 and [3](PF6)2 were found both more cytotoxic after light activation than in the dark, with a photo index of 4. Considering the very low singlet oxygen quantum yields of these compounds, and the lack of cytotoxicity of the photoreleased Hmte thioether ligand, it can be concluded that the toxicity observed after light activation is due to the photoreleased aqua complexes [Ru(tpy)(NN)(OH2)]2+, and thus that [2](PF6)2 and [3](PF6)2 are promising PACT candidates. Graphic abstract

S-Nitrosoglutathione incorporated in poly(ethylene glycol) matrix: potential use for topical nitric oxide delivery

Nitric Oxide ◽  
2004 ◽  
Vol 11 (3) ◽  
pp. 263-272 ◽  
Author(s):  
Amedea Barozzi Seabra ◽  
Gabriela Freitas Pereira de Souza ◽  
Lilian Lúcia da Rocha ◽  
Marcos Nogueira Eberlin ◽  
Marcelo Ganzarolli de Oliveira
Keyword(s):  
Nitric Oxide ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Matrix Potential ◽  
Poly Ethylene ◽  
Nitric Oxide Delivery ◽  
Potential Use

Light-Induced Acid Generation on a Gatekeeper for Smart Nitric Oxide Delivery

ACS Nano ◽  
2016 ◽  
Vol 10 (4) ◽  
pp. 4199-4208 ◽  
Author(s):  
Hyung Woo Choi ◽  
Jihoon Kim ◽  
Jinhwan Kim ◽  
Yonghwi Kim ◽  
Hyun Beom Song ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Acid Generation ◽  
Nitric Oxide Delivery

Perivascular Nitric Oxide Delivery to Saphenous Vein Grafts Prevents Graft Stenosis after Coronary Artery Bypass Grafting: A Novel Sheep Model

Cardiology ◽  
2011 ◽  
Vol 118 (1) ◽  
pp. 8-15 ◽  
Author(s):  
Kyomars Abbasi ◽  
Keivan Shalileh ◽  
Maryam Sotudeh Anvari ◽  
Shahram Rabbani ◽  
Abolfazl Mahdanian ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Coronary Artery ◽  
Coronary Artery Bypass Grafting ◽  
Saphenous Vein ◽  
Artery Bypass ◽  
Bypass Grafting ◽  
Sheep Model ◽  
Vein Grafts ◽  
Graft Stenosis ◽  
Nitric Oxide Delivery

scholarly journals Growth phase-dependent subcellular localization of nitric oxide synthase in maize cells

FEBS Letters ◽  
1999 ◽  
Vol 445 (2-3) ◽  
pp. 283-286 ◽  
Author(s):  
Euripedes A Ribeiro ◽  
Fernando Q Cunha ◽  
Wirla M.S.C Tamashiro ◽  
Ione S Martins
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Subcellular Localization ◽  
Growth Phase ◽  
Oxide Synthase
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