Overview of potential molecular targets for hydrogen sulfide: A new strategy for treating erectile dysfunction

Nitric Oxide ◽  
2015 ◽  
Vol 50 ◽  
pp. 65-78 ◽  
Author(s):  
Serap Gur ◽  
Philip J. Kadowitz ◽  
Suresh C. Sikka ◽  
Taylor C. Peak ◽  
Wayne J.G. Hellstrom
Keyword(s):  
Hydrogen Sulfide ◽  
Erectile Dysfunction ◽  
Molecular Targets ◽  
New Strategy

Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed

2012 ◽  
Vol 92 (2) ◽  
pp. 791-896 ◽  
Author(s):  
Rui Wang
Keyword(s):  
Heart Failure ◽  
Hydrogen Sulfide ◽  
Erectile Dysfunction ◽  
Mammalian Cells ◽  
New Technologies ◽  
Molecular Targets ◽  
Signaling Proteins ◽  
Physiological Functions ◽  
Physiological Importance

The important life-supporting role of hydrogen sulfide (H2S) has evolved from bacteria to plants, invertebrates, vertebrates, and finally to mammals. Over the centuries, however, H2S had only been known for its toxicity and environmental hazard. Physiological importance of H2S has been appreciated for about a decade. It started by the discovery of endogenous H2S production in mammalian cells and gained momentum by typifying this gasotransmitter with a variety of physiological functions. The H2S-catalyzing enzymes are differentially expressed in cardiovascular, neuronal, immune, renal, respiratory, gastrointestinal, reproductive, liver, and endocrine systems and affect the functions of these systems through the production of H2S. The physiological functions of H2S are mediated by different molecular targets, such as different ion channels and signaling proteins. Alternations of H2S metabolism lead to an array of pathological disturbances in the form of hypertension, atherosclerosis, heart failure, diabetes, cirrhosis, inflammation, sepsis, neurodegenerative disease, erectile dysfunction, and asthma, to name a few. Many new technologies have been developed to detect endogenous H2S production, and novel H2S-delivery compounds have been invented to aid therapeutic intervention of diseases related to abnormal H2S metabolism. While acknowledging the challenges ahead, research on H2S physiology and medicine is entering an exponential exploration era.

Hydrogen Sulfide in Physiological and Pathological Mechanisms in Brain

2018 ◽  
Vol 17 (9) ◽  
pp. 654-670 ◽  
Author(s):  
Mohit Kumar ◽  
Rajat Sandhir
Keyword(s):  
Nitric Oxide ◽  
Traumatic Brain Injury ◽  
Hydrogen Sulfide ◽  
Neurodegenerative Disorders ◽  
Neurological Disorders ◽  
Scientific Community ◽  
Molecular Targets ◽  
Long Term Potentiation ◽  
Term Potentiation

Background & Objective: Hydrogen sulfide [H2S] has been widely known as a toxic gas for more than 300 years in the scientific community. However, the understanding about this small molecule has changed after the discovery of involvement of H2S in physiological and pathological mechanisms in brain. H2S is a third gasotransmitter and neuromodulator after carbon monoxide [CO] and nitric oxide [NO]. H2S plays an important role in memory and cognition by regulating long-term potentiation [LTP] and calcium homeostasis in neuronal cells. The disturbances in endogenous H2S levels and trans-sulfuration pathway have been implicated in neurodegenerative disorders like Alzheimer’s disease, Parkinson disease, stroke and traumatic brain injury. According to the results obtained from various studies, H2S not only behaves as neuromodulator but also is a potent antioxidant, anti-inflammatory and anti-apoptotic molecule suggesting its neuroprotective potential. Conclusion: Recently, there is an increased interest in developing H2S releasing pharmaceuticals to target various neurological disorders. This review covers the information about the involvement of H2S in neurodegenerative diseases, its molecular targets and its role as potential therapeutic molecule.

scholarly journals Bio-orthogonal “click-and-release” donation of caged carbonyl sulfide (COS) and hydrogen sulfide (H2S)

2017 ◽  
Vol 53 (8) ◽  
pp. 1378-1380 ◽  
Author(s):  
Andrea K. Steiger ◽  
Yang Yang ◽  
Maksim Royzen ◽  
Michael D. Pluth
Keyword(s):  
Hydrogen Sulfide ◽  
Click Reaction ◽  
Carbonyl Sulfide ◽  
Diels Alder ◽  
Inverse Electron Demand ◽  
New Strategy ◽  
Electron Demand

The inverse-electron demand Diels–Alder (IEDDA) click reaction between thiocarbamate-functionalized trans-cyclooctenes and tetrazines provides a new strategy for bio-orthogonal COS/H2S delivery.

scholarly journals Percutaneous Cavernous Nerve Electro-Stimulation for Treatment of Erectile Dysfunction

BioMedica ◽  
2020 ◽  
Vol 36 (4) ◽  
pp. 334-338
Author(s):  
Qing Hu ◽  
Wen-Zhi Wang ◽  
Bo-Dong Lv ◽  
Guo-Guang Lou
Keyword(s):  
Erectile Dysfunction ◽  
Evoked Potential ◽  
Three Dimensional ◽  
Final Diagnosis ◽  
Urethral Injury ◽  
Nocturnal Penile Tumescence ◽  
Cavernous Nerve ◽  
New Strategy ◽  
Dimensional Reconstruction ◽  
Dorsal Nerve

Pelvic fracture urethral injury (PFUI) is the major etiological factor of neurological erectile dysfunction (NED). We reported a patient whose Index of Erectile Function-5 (IIEF-5) score was 7 (severe ED) and experienced a failed treatment of Tadalafil. NED was the final diagnosis made by examinations such as nocturnal penile tumescence (NPT), penile cavernous contrast and three-dimensional reconstruction and the penial dorsal nerve somatosensory evoked potential. Percutaneous cavernous nerve electro-stimulation was used as treatment for NED. After three courses of treatment, the IIEF-5 score was up to 18 points and the level of erection hardness was between grade III and IV. We concluded that percutaneous cavernous nerve electro-stimulation will be a new strategy to treat patients with NED with PFUI history.

Erectile dysfunction is associated with defective L-cysteine/hydrogen sulfide pathway in human corpus cavernosum and penile arteries

2020 ◽  
Vol 884 ◽  
pp. 173370
Author(s):  
José M. La Fuente ◽  
Alejandro Sevilleja-Ortiz ◽  
Esther García-Rojo ◽  
Mariam El Assar ◽  
Argentina Fernández ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Erectile Dysfunction ◽  
Corpus Cavernosum ◽  
Penile Arteries

scholarly journals Modulation of the functions of myeloid‐derived suppressor cells : a new strategy of hydrogen sulfide anti‐cancer effects

2019 ◽  
Vol 177 (4) ◽  
pp. 884-897 ◽  
Author(s):  
Paola De Cicco ◽  
Giuseppe Ercolano ◽  
Valentina Rubino ◽  
Giuseppe Terrazzano ◽  
Giuseppina Ruggiero ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells ◽  
Anti Cancer ◽  
New Strategy
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