scholarly journals Modulation of the functions of myeloid‐derived suppressor cells : a new strategy of hydrogen sulfide anti‐cancer effects

2019 ◽  
Vol 177 (4) ◽  
pp. 884-897 ◽  
Author(s):  
Paola De Cicco ◽  
Giuseppe Ercolano ◽  
Valentina Rubino ◽  
Giuseppe Terrazzano ◽  
Giuseppina Ruggiero ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells ◽  
Anti Cancer ◽  
New Strategy

scholarly journals CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of the Ligands of Receptors CCR1, CCR2, CCR3, and CCR4

2020 ◽  
Vol 21 (21) ◽  
pp. 8412
Author(s):  
Jan Korbecki ◽  
Klaudyna Kojder ◽  
Donata Simińska ◽  
Romuald Bohatyrewicz ◽  
Izabela Gutowska ◽  
...  
Keyword(s):  
Physiological Function ◽  
Suppressor Cells ◽  
Tumor Infiltrating Lymphocytes ◽  
Myeloid Derived Suppressor Cells ◽  
Anti Cancer ◽  
Organ Specific ◽  
Cc Chemokines ◽  
Infiltrating Lymphocytes ◽  
Tumor Associated Neutrophils

CC chemokines, a subfamily of 27 chemotactic cytokines, are a component of intercellular communication, which is crucial for the functioning of the tumor microenvironment. Although many individual chemokines have been well researched, there has been no comprehensive review presenting the role of all known human CC chemokines in the hallmarks of cancer, and this paper aims at filling this gap. The first part of this review discusses the importance of CCL1, CCL3, CCL4, CCL5, CCL18, CCL19, CCL20, CCL21, CCL25, CCL27, and CCL28 in cancer. Here, we discuss the significance of CCL2 (MCP-1), CCL7, CCL8, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL22, CCL23, CCL24, and CCL26. The presentation of each chemokine includes its physiological function and then the role in tumor, including proliferation, drug resistance, migration, invasion, and organ-specific metastasis of tumor cells, as well as the effects on angiogenesis and lymphangiogenesis. We also discuss the effects of each CC chemokine on the recruitment of cancer-associated cells to the tumor niche (eosinophils, myeloid-derived suppressor cells (MDSC), tumor-associated macrophages (TAM), tumor-associated neutrophils (TAN), regulatory T cells (Treg)). On the other hand, we also present the anti-cancer properties of CC chemokines, consisting in the recruitment of tumor-infiltrating lymphocytes (TIL).

Modulation of PD-1/PD-L1 axis in myeloid-derived suppressor cells by anti-cancer treatments

2021 ◽  
Vol 362 ◽  
pp. 104301
Author(s):  
Elena Jachetti ◽  
Sabina Sangaletti ◽  
Claudia Chiodoni ◽  
Roberto Ferrara ◽  
Mario P. Colombo
Keyword(s):  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells ◽  
Cancer Treatments ◽  
Anti Cancer

scholarly journals Myeloid-derived suppressor cells and their role in gynecological malignancies

Tumor Biology ◽  
2018 ◽  
Vol 40 (7) ◽  
pp. 101042831877648 ◽  
Author(s):  
Seiji Mabuchi ◽  
Eriko Yokoi ◽  
Naoko Komura ◽  
Tadashi Kimura
Keyword(s):  
Immune Responses ◽  
Current Knowledge ◽  
Gynecological Cancer ◽  
Suppressor Cells ◽  
Heterogeneous Population ◽  
Cancer Therapies ◽  
Myeloid Derived Suppressor Cells ◽  
Immunosuppressive Activity ◽  
Anti Cancer ◽  
Immature Myeloid Cells

Myeloid-derived suppressor cells are a heterogeneous population of immature myeloid cells that exhibit immunosuppressive activity (they block the proliferation and activity of both T cells and natural killer cells). In addition to their role in suppressing immune responses, myeloid-derived suppressor cells directly stimulate tumor cell proliferation, metastasis, and angiogenesis. In the area of gynecological cancer, increased numbers of circulating myeloid-derived suppressor cells or tumor-infiltrating myeloid-derived suppressor cells have been detected, and the increased frequencies of myeloid-derived suppressor cells are associated with a poor prognosis. Thus, the successful myeloid-derived suppressor cells depletion may hold the key to maximizing existing anti-cancer therapies and improving the prognosis of gynecological cancer. In this review, we summarize current knowledge regarding myeloid-derived suppressor cells biology, clinical significance of myeloid-derived suppressor cells, and the potential myeloid-derived suppressor cells–targeting strategies in gynecological cancer.

scholarly journals A polysaccharide derived from Lentinus edodes impairs the immunosuppressive function of myeloid-derived suppressor cells via the p38 pathways

RSC Advances ◽  
2017 ◽  
Vol 7 (58) ◽  
pp. 36533-36540 ◽  
Author(s):  
Jun Du ◽  
Ruijie Wang ◽  
Wensheng Zhang ◽  
Chao Zhang ◽  
Xiao Li ◽  
...  
Keyword(s):  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells ◽  
Lentinus Edodes ◽  
Immune Suppressor Cells ◽  
Anti Cancer ◽  
Immune Suppressor

MPSSS may reverse the function of the MSC2 cells through p38 activation and ERK suppression and provide a novel anti-cancer strategy by targeting myeloid immune suppressor cells.

Sign in / Sign up

Export Citation Format

Share Document